Patents by Inventor Yi-Qiang Cheng

Yi-Qiang Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HDAC inhibitors and methods of treatment using the same
    Patent number: 11149062
    Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: October 19, 2021
    Assignee: UWM Research Foundation, Inc.
    Inventors: Yi-Qiang Cheng, M. Mahmun Hossain, Douglas Steeber, Karyn Frick, Steven Clark, Joseph Ulicki
  • NOVEL HDAC INHIBITORS AND METHODS OF TREATMENT USING THE SAME
    Publication number: 20180258135
    Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.
    Type: Application
    Filed: October 29, 2015
    Publication date: September 13, 2018
    Inventors: Yi-Qiang Cheng, M. Mahmun Hossain, Douglas Steeber, Karyn Frick, Steven Clark, Joseph Ulicki
  • Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs
    Patent number: 8148102
    Abstract: Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: April 3, 2012
    Assignee: UWM Research Foundation, Inc.
    Inventor: Yi-Qiang Cheng
  • SEQUENCES FOR FK228 BIOSYNTHESIS AND METHODS OF SYNTHESIZING FK228 AND FK228 ANALOGS
    Publication number: 20100261878
    Abstract: Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.
    Type: Application
    Filed: February 8, 2008
    Publication date: October 14, 2010
    Applicant: UWM RESEARCH FOUNDATION, INC.
    Inventor: Yi-Qiang Cheng
  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Patent number: 7452693
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 18, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang
  • DISCRETE ACYLTRANSFERASES ASSOCIATED WITH TYPE I POLYKETIDE SYNTHASES AND METHODS OF USE
    Publication number: 20080124757
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Application
    Filed: October 18, 2006
    Publication date: May 29, 2008
    Inventors: Ben SHEN, Yi-Qiang Cheng, Gong-Li Tang
  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Patent number: 7153667
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: December 26, 2006
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang
  • Leinamycin biosynthesis gene cluster and its components and their uses
    Publication number: 20050080247
    Abstract: This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus. The leinamycin gene cluster provides a hybrid polyketide synthase/nonribosomal peptide synthetase pathway. Elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for leinamycins, leinamycin analogs, and various other polyketides, peptides, and hybrid peptide-polyketide natural products.
    Type: Application
    Filed: March 22, 2002
    Publication date: April 14, 2005
    Inventors: Ben Shen, Yi-qiang Cheng, Gong-li Tang
  • Discrete acyltransferases associated with type I polyketide synthases and methods of use
    Publication number: 20030175888
    Abstract: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase/nonribosomal peptide synthetases.
    Type: Application
    Filed: December 9, 2002
    Publication date: September 18, 2003
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Yi-Qiang Cheng, Gong-Li Tang