Abstract: A display may have an array of organic light-emitting diodes that form an active area on a flexible substrate. Metal traces may extend between the active area and an inactive area of the flexible substrate. Display driver circuitry such as a display driver integrated circuit may be coupled to the inactive area. The metal traces may extend across a bend region in the flexible substrate. The flexible substrate may be bent in the bend region. The flexible substrate may be made of a thin flexible material to reduce metal trace bending stress. A coating layer in the bend region may be provided with an enhanced elasticity to allow its thickness to be reduced. The flexible substrate may be bent on itself and secured within an electronic device without using a mandrel.

Abstract: The invention provides a solid composition and preparation method thereof. The solid composition comprises fingolimod or a pharmaceutically acceptable salt thereof and a diluent, in which the diluent is complex starch. The solid composition having good compatibility of excipients, stability and dissolution can improve drug safety and increase the dissolution and absorption in vivo. The method for the preparation of the solid composition is simple to operate, low cost, and suitable for industrial production.

Abstract: A display may have an array of organic light-emitting diodes that form an active area on a flexible substrate. Metal traces may extend between the active area and an inactive area of the flexible substrate. Display driver circuitry such as a display driver integrated circuit may be coupled to the inactive area. The metal traces may extend across a bend region in the flexible substrate. The flexible substrate may be bent in the bend region. The flexible substrate may be made of a thin flexible material to reduce metal trace bending stress. A coating layer in the bend region may be provided with an enhanced elasticity to allow its thickness to be reduced. The flexible substrate may be bent on itself and secured within an electronic device without using a mandrel.

Abstract: A flexible substrate may have one or more bends. A bend in a flexible substrate may be made along a bend axis. Conductive traces in the flexible substrate may have elongated shapes. Each conductive trace may extend along a longitudinal axis that is perpendicular to the bend axis. Metal or other conductive materials may form the conductive traces. The traces may be formed from a chain of linked segments. Each segment may have patterned trace portions that surround one, two, or more than two openings. Traces may also be formed that have multiple layers of metal or other conductive material interconnected using vias. A polymer layer may cover the traces to align a neutral stress plane with the traces and to serve as a moisture barrier layer.

Abstract: A thin-film transistor layer, an organic light-emitting diode layer, and other layers may be used in forming an array of pixels on a substrate in a display. Vias may be formed through one or more layers of the display such as the substrate layer to form vertical signal paths. The vertical signal paths may convey signals between display driver circuitry underneath the display and the pixels. The vias may pass through a polymer layer and may contact pads formed within openings in the substrate. Vias may pass through a glass support layer. Metal traces may be formed in the thin-film transistor layer to create signal paths such as data lines and gate lines. Portions of the metal traces may form vias through a polymer layer such as a substrate layer or a polymer layer that has been formed on top of the substrate layer.

Abstract: A display may have an array of organic light-emitting diodes that form an active area on a flexible substrate. Metal traces may extend between the active area and an inactive area of the flexible substrate. Display driver circuitry such as a display driver integrated circuit may be attached to a flexible printed circuit that is attached to the flexible substrate in the inactive area. The metal traces may extend across a bend region in the flexible substrate. The flexible substrate may be bent in the bend region. The flexible substrate may be locally thinned in the bend region. A neutral stress plane adjustment layer may cover the metal traces in the bend region. The neutral stress plane adjustment layer may include polymer layers such as an encapsulation layer, a pixel definition layer, a planarization layer, and a layer that covers a pixel definition layer and planarization layer.

Abstract: A display may have an array of organic light-emitting diodes that form an active area on a flexible substrate. Metal traces may extend between the active area and an inactive area of the flexible substrate. Display driver circuitry such as a display driver integrated circuit may be coupled to the inactive area. The metal traces may extend across a bend region in the flexible substrate. The flexible substrate may be bent in the bend region. The flexible substrate may be made of a thin flexible material to reduce metal trace bending stress. A coating layer in the bend region may be provided with an enhanced elasticity to allow its thickness to be reduced. The flexible substrate may be bent on itself and secured within an electronic device without using a mandrel.

Abstract: A flexible substrate may have one or more bends. A bend in a flexible substrate may be made along a bend axis. Conductive traces in the flexible substrate may have elongated shapes. Each conductive trace may extend along a longitudinal axis that is perpendicular to the bend axis. Metal or other conductive materials may form the conductive traces. The traces may be formed from a chain of linked segments. Each segment may have patterned trace portions that surround one, two, or more than two openings. Traces may also be formed that have multiple layers of metal or other conductive material interconnected using vias. A polymer layer may cover the traces to align a neutral stress plane with the traces and to serve as a moisture barrier layer.

Abstract: This disclosure provides systems, methods and apparatus for integrating a photovoltaic cell with a display device. One innovative aspect of the subject matter described in this disclosure can be implemented in a display device that includes a first transparent panel and an array of display elements arranged adjacent the first panel. Each display element includes a shutter-based assembly including at least one shutter and at least one actuator capable of translating the shutter to modulate light. The display device also includes a photovoltaic aperture layer arranged adjacent the first panel. The photovoltaic aperture layer includes an array of apertures, each aperture allowing light from a corresponding display element to pass through the photovoltaic aperture layer for display. The display device further includes an array of conductive leads capable of receiving electrical power generated from the photovoltaic aperture layer.

Abstract: Processes and C/D box small nucleolar RNAs (snoRNAs) for altering telomerase activity and altering telomerase length are described. The processes of the invention involve the use of C/D box snoRNAs for targeted 2?-O-methylation modification of nucleotides in a pseudoknot region of the telomerase RNA. Depending on their position, the 2?-O-methylation modifications can cause an increase in telomerase activity and subsequent telomere lengthening or a decrease in telomerase activity and subsequent telomere shortening.

Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.

Abstract: This disclosure provides systems, methods and apparatuses for pixel vias. In one aspect, a method of forming an electromechanical device having a plurality of pixels includes depositing an electrically conductive black mask on a substrate at each of four corners and along at least one edge region of each pixel, depositing a dielectric layer over the black mask, depositing an optical stack including a stationary electrode over the dielectric layer, and depositing a mechanical layer over the optical stack. The method further includes providing a conductive via in a first pixel of the plurality of pixels, the via disposed in the dielectric layer and electrically connecting the stationary electrode to the black mask, the via disposed in a position along an edge of the first pixel, spaced offset from the edge of the first pixel in a direction towards the center of the first pixel.

Abstract: This disclosure provides systems, methods and apparatuses for pixel vias. In one aspect, a method of forming an electromechanical device having a plurality of pixels includes depositing an electrically conductive black mask on a substrate at each of four corners of each pixel, depositing a dielectric layer over the black mask, depositing an optical stack including a stationary electrode over the dielectric layer, depositing a mechanical layer over the optical stack, and anchoring the mechanical layer over the optical stack at each corner of each pixel. The method further includes providing a conductive via in a first pixel of the plurality of pixels, the via in the dielectric layer electrically connecting the stationary electrode to the black mask, the via disposed at a corner of the first pixel, offset from where the mechanical layer is anchored over the optical stack in an optically non-active area of the first pixel.

Abstract: This disclosure provides mechanical layers and methods of forming the same. In one aspect, an electromechanical systems device includes a substrate and a mechanical layer having an actuated position and a relaxed position. The mechanical layer is spaced from the substrate to define a collapsible gap. The gap is in a collapsed condition when the mechanical layer is in the actuated position and in a non-collapsed condition when the mechanical layer is in the relaxed position. The mechanical layer includes a reflective layer, a conductive layer, and a supporting layer. The supporting layer is positioned between the reflective layer and the conductive layer and is configured to support the mechanical layer.

Abstract: Systems, methods and apparatus are provided for controlling launch effects of movable layers in electromechanical systems (EMS) devices. First and second EMS devices with first and second step creating layers are positioned over a substrate and spaced, by different gaps, from the movable layers of the EMS devices. The movable layers of the first and second EMS devices include steps having different heights and/or different edge spacing from the center of an anchoring region of each EMS device. The different steps can provide different launch effects for different EMS devices, and if the same thickness of sacrificial material is used for the different devices, the different launch effects can be responsible for different gap heights in the unbiased conditions.

Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.

Abstract: This disclosure provides systems, methods and apparatus for electromechanical systems displays. In one aspect, the display can include a plurality of electromechanical display elements including a first set of electromechanical display elements and a second set of electromechanical display elements. Each electromechanical display element can include a common electrode and a segment electrode. Each of the segment electrodes of the first set of electromechanical display elements can have a first area located under the common electrodes of the first set. Each of the segment electrodes of the second set of electromechanical display elements can have a second area smaller than the first area located under the common electrodes of the second set. In some implementations, an actuation voltage of each electromechanical display element of the first set is approximately the same as an actuation voltage of each electromechanical display element of the second set.

Abstract: A thickness detection device comprises: a feed roller (130), a thickness detection unit (110,210) and a thickness measurement unit (120,220).

Abstract: Systems, methods and apparatuses reduce stress and/or reduce stiffness in a movable layer of an electromechanical systems (EMS) device. Stress or stiffness can be reduced by including one or more compressive stress layers to compensate for the tensile stress exhibited by other layers of the movable layer. The movable layer can include a dielectric core with a first tensile stress layer and a first compressive stress layer on a first side of the dielectric core, and a second tensile stress layer and a second compressive stress layer on a second side of the dielectric core.

Abstract: This disclosure provides systems, methods and apparatus for writing data to a display. In one aspect, the display includes an array of display elements arranged at the intersection of a plurality of common lines and segment lines. The display also includes a common driver and a segment driver coupled to the common lines and segment lines. According to one aspect, the display includes a greater number of segment lines than columns of display elements in the array. According to another aspect, the display may also include a first number of display element segment electrodes that are coupled to each other along a first common line, and a second number of display element segment electrodes coupled to each other along a second common line, where the first number is different than the second number.