Abstract: The subject matter described herein is directed to a chimera molecule such as a polypeptide or protein chimera useful for treating or preventing a viral infection or reducing the severity, incidence, or transmissibility of a viral infection, to nucleic acid molecules encoding the polypeptide or protein chimera, and to pharmaceutical compositions containing them. Also, methods of generating such antiviral polypeptide or protein chimera, of generating nucleic acid molecules encoding the antiviral polypeptide or protein chimera, and of generating pharmaceutical compositions containing the same, and methods of using the same for treatment or prevention of a SARS-CoV-2 infection, or to reduce the severity, incidence, or transmissibility of a of a SARS-CoV-2 infection, are described.

Abstract: The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9 TCC) and C5a anaphylatoxin-mediated inflammation and, thus, treating complement-associated disorders. The antibodies have a number of improved properties relative to eculizumab, including, e.g., increased serum half-life in a human.

Abstract: A method for handling a call using Sessions Initiation Protocol (SIP) includes sending an INVITE or a first media type by a network side to user equipment, sending an UPDATE of a second media type by the user equipment to the network side, receiving an SIP global failure response for the UPDATE by the user equipment from the network side, sending an SIP success response for the INVITE of the first media type by the user equipment to the network side, receiving an ACK of the first media type by the user equipment from the network side, and establishing a call session of the first media type between the user equipment and the network side.

Abstract: The embodiments of the disclosure provide a method for reducing computational loading while generating a content and a host. The method includes: obtaining a texture map and a plurality of object texture coordinates, wherein the object texture coordinates correspond to at least one virtual object in the texture map; obtaining a first mesh map corresponding to the texture map; determining a first mesh segment and a second mesh segment within the first mesh map based on the object texture coordinates, wherein the first mesh segment does not correspond to the object texture coordinates, and the second mesh segment corresponds to the object texture coordinates; modifying the first mesh map into a second mesh map via reducing a first segment area of the first mesh segment; and generating a visual content via performing an asynchronous time warp operation on the texture map based on the second mesh map.

Abstract: A computer-readable storage medium stores instructions to configure one or more processors of a Further Reduced Capacity (F-RedCap) UE for operation in a 5G NR network, and to cause the F-RedCap UE to perform operations including decoding a PBCH to obtain a numerology parameter. A maximum resource block (RB) allocation is determined for a bandwidth associated with the numerology parameter. The maximum RB allocation is adjusted based on a reduced bandwidth associated with the F-RedCap UE to obtain an adjusted RB allocation. A maximum data rate is determined based on the numerology parameter and the adjusted RB allocation. Data is encoded for an uplink (UE) transmission to a base station. The UE transmission uses the maximum data rate.

Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

Abstract: A UE configured for operating in a 5G NR network may decode signalling that schedules two physical downlink shared channels (PDSCHs) in a same time slot. When the UE is a reduced-bandwidth (RBW) reduced-capacity (RedCap) UE (RBW-RedCap UE), the UE may determine if a total number of allocated PRBs in an OFDM symbol for the two scheduled PDSCHs exceed a predetermined value when the two scheduled PDSCHs either partially or fully overlap in time in non-overlapping PRBs. The UE may also prioritize decoding of one of the two scheduled PDSCHs when the total number of allocated PRBs exceed the predetermined value and when the two scheduled PDSCHs either partially or fully overlap in time in non-overlapping PRBs. If a first of the two scheduled PDSCHs is a unicast PDSCH and a second of the two scheduled PDSCHs is a broadcast PDSCH, the UE may prioritize decoding of the unicast PDSCH.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, L1, L2, L3, A1, A2, A3, A4, G1, G2, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: The present disclosure relates to the field of pharmaceutical preparations, and in particular to use of a milk exosome in the manufacture of a drug carrier. The present disclosure uses milk exosomes as a drug carrier. The exosomes are derived from milk with safety and reliability, and has the functional properties of milk exosomes. Using the exosomes as a drug carrier can achieve oral administration of protein drugs. Using the milk exosomes to load liraglutide can achieve oral administration of liraglutide and treat type 2 diabetes.

Abstract: This application provides a positioning method and an apparatus. The method includes: A location management device provides assistance information for a terminal device, where the assistance information includes information about one or more cells used for positioning of the terminal device and reference signal configuration information of each of the one or more cells. The location management device provides a first request message for the terminal device, where the first request message includes measurement reporting configuration information. The location management device receives a reference signal measurement result of each of the one or more cells from the terminal device, where the reference signal measurement result is obtained based on the measurement reporting configuration information. The location management device obtains a DAOD of the terminal device relative to each of the one or more cells based on the reference signal measurement result.

Abstract: The disclosure discloses a method for preparing a battery-grade nickel-cobalt-manganese sulfate solution from low nickel matte.

Abstract: The disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-generation (4G) communication system such as long term evolution (LTE). The disclosure provide a semi-persistent scheduling method, a base station device and a user equipment, wherein, the semi-persistent scheduling method comprises: transmitting a configuration information of semi-persistent scheduling parameters to a user equipment (UE), so that the UE performs a semi-persistent scheduling data transmission based on the configuration information; and performing the semi-persistent scheduling data transmission based on the configuration information of the semi-persistent scheduling parameters.

Abstract: A voice call management method is provided. The voice call management method may be applied to an apparatus. The voice call management method may include the following steps. The apparatus may determine the current scenario associated with the operation environment of the apparatus. Then, the apparatus may determine to perform a voice call through a modem (MD) voice engine or through an application processor (AP) voice engine according to the current scenario.

Abstract: The embodiments of the present disclosure provide an information processing method, an information processing apparatus, an electronic device, and a storage medium.

Abstract: The present invention provides a coal feeding control method and system for a small pulverized coal silo, the method includes: acquiring a boiler load increase signal, and determining the target function F(t) for boiler load control obtaining the current coal mill output signal B(t), where B(t) is the fuel quantity signal at the outlet of the coal mill that changes over time from the start time; comparing B(t) with F(t): if B(t) cannot meet the fuel quantity requirements of F(t), activate the small pulverized coal silo connected to the boiler; otherwise, the small pulverized coal silo remains inactive; determining the coal feeding signal f(t) for the small pulverized coal silo, and further determining the coal feeding control signal f(t) for the small pulverized coal silo; controlling the small pulverized coal silo to feed coal to the boiler, quickly changing the combustion rate in the furnace, and increasing the boiler load.

Abstract: Acupuncture needles may be used for piercing tissue with less trauma than may occur when employing larger gauge needles. However, because acupuncture needles are fabricated and packaged differently than are larger gauge needles, acupuncture needles may be less compatible with certain manufacturing processes. Needle assemblies compatible with manufacturing processes may comprise a continuous support material having a plurality of apertures defined therein, and a first injection molded coupler that surrounds a proximal portion of an acupuncture needle and connects the acupuncture needle to a first location upon the continuous support material, such that the acupuncture needle is held in a pre-determined orientation with respect to a longitudinal axis of the first injection molded coupler. The acupuncture needles in adjacent apertures may also be spaced apart substantially uniformly.

Abstract: A wedge shaped container formed from a folded web of flexible material. The container comprises a base (1), a rear wall (2) connected to the base, and a pair of upstanding side walls decreasing in height from the rear wall to the opposite end of the base. Each side wall is formed of two side wall panels (4, 6) connected at an edge of the base and connected by a hinge joint. From a fold-flat configuration, folding of the rear wall (2) away from the base (1) causes the side wall panels (4, 6) to be folded inwardly into the erected configuration. The container may have an integral lid (8). The invention also extends to a method of making a blank using a sequence of cuts to create unsupported file regions.

Abstract: Embodiments disclosed herein include a method of setting a target profile. In an embodiment, the method comprises obtaining a first gain curve for one or more temperature sensor offsets, and obtaining a second gain curve for one or more zone multipliers. In an embodiment, the method further comprises combining the first gain curve and the second gain curve into a thermal model. In an embodiment, the method further comprises obtaining a reference data set, and using the thermal model to generate temperature sensor offsets and/or zone multipliers to apply to the reference data set in order to generate the target profile.

Abstract: Software vulnerability in an automotive system is analyzed by receiving one or more application files of a software application developed for the automotive system; analyzing: the one or more application files based on an automotive system specification, data from one or more security databases, an expert preference, and information about modules and functions of the software application; identifying one or more vulnerabilities in the one or more application files based on the analysis; and updating the one or more databases with the one or more vulnerabilities, wherein the updated one or more databases are used to detect the one or more vulnerabilities in the software application running on the automotive system in real-time, wherein one or more patches are provided to secure the automotive system.

Abstract: A method for dynamically controlling high-pressure leaching reaction condition of laterite nickel ore includes: setting a target temperature and a target pressure of an high-pressure reactor; obtaining the heat power required for heating the feeding pulp to the target temperature; obtaining the heat power brought by the acid; obtaining the required new steam thermal power; obtaining the required new steam flow; adjusting the real-time flow of the new steam to the required flow of the new steam, and adjusting the exhaust valve opening degree and discharge flow rate of the high-pressure reactor to make the real-time pressure of the high-pressure reactor equal to the target pressure, and adjusting the flow rate of the new steam to make the real-time temperature of the high-pressure reactor equal to the target temperature.