Patents by Inventor Yi-Yin Ku

Yi-Yin Ku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
    Publication number: 20050256127
    Abstract: The present invention relates to salts of 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one, processes for their preparation, pharmaceutical compositions comprising such compounds, method of using them, and a process for preparing the active agent.
    Type: Application
    Filed: May 12, 2004
    Publication date: November 17, 2005
    Inventors: Yi-Yin Ku, Timothy Grieme, Yu-Ming Pu, Ashok Bhatia, Pascal Toma, Rodger Henry, Leslie Hollis
  • Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
    Publication number: 20050256118
    Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X?, Y, Y?, Z, Z?, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: May 12, 2004
    Publication date: November 17, 2005
    Inventors: Robert Altenbach, Lawrence Black, Sou-Jen Chang, Marlon Cowart, Ramin Faghih, Gregory Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill Lukin, Diana Nersesian, Yu-ming Pu, Michael Curtis
  • Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
    Publication number: 20050256309
    Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X?, Y, Y?, Z, and Z? are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: May 12, 2004
    Publication date: November 17, 2005
    Inventors: Robert Altenbach, Lawrence Black, Sou-jen Chang, Marlon Cowart, Ramin Faghih, Gregory Gfesser, Yi-yin Ku, Huaqing Liu, Kirill Lukin, Diana Nersesian, Yu-ming Pu, Michael Curtis
  • Process for preparing amine-substituted benzofurans
    Publication number: 20050054677
    Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
    Type: Application
    Filed: September 21, 2004
    Publication date: March 10, 2005
    Inventors: Yi-Yin Ku, Yu-Ming Pu, Marlon Cowart, Timothy Grieme, Ashok Gupta, Daniel Plata
  • Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
    Publication number: 20040260100
    Abstract: The invention relates to a process for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. Novel intermediates also are described.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 23, 2004
    Inventors: Yi-Yin Ku, Marlon D. Cowart, Padam N. Sharma
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040248899
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: April 30, 2004
    Publication date: December 9, 2004
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Process for preparing amine-substituted benzofurans
    Patent number: 6822101
    Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: November 23, 2004
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, Yu-Ming Pu, Marlon D. Cowart, Timothy A. Grieme, Ashok K. Gupta, Daniel J. Plata
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040224953
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: September 25, 2003
    Publication date: November 11, 2004
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040224952
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: May 7, 2003
    Publication date: November 11, 2004
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Spirocyclopropyl amides and acids and their therapeutic applications
    Publication number: 20040204396
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: October 22, 2003
    Publication date: October 14, 2004
    Inventors: Youseff L. Bennani, William H. Bunnelle, Sou-Jen Chang, Sanjay R. Chemburkar, Jinhua Chen, Michael J. Dart, Dilinie Fernando, Yi-Yin Ku, Mark Lockwood, Lei Wang
  • Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
    Publication number: 20040171845
    Abstract: The invention relates to a process for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. Novel intermediates also are described.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 2, 2004
    Inventors: Yi-Yin Ku, Marlon D. Cowart, Padam N. Sharma
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040152704
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: October 22, 2003
    Publication date: August 5, 2004
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani, Michael P. Curtis
  • Process for preparing amine-substituted benzofurans
    Publication number: 20040133007
    Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
    Type: Application
    Filed: September 5, 2003
    Publication date: July 8, 2004
    Inventors: Yi-Yin Ku, Yu-Ming Pu, Marlon D. Cowart, Timothy A. Grieme, Ashok K. Gupta, Daniel J. Plata
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040092521
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: November 12, 2002
    Publication date: May 13, 2004
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani
  • Spirocyclopropyl amides and acids and their therapeutic applications
    Publication number: 20040077616
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: October 22, 2002
    Publication date: April 22, 2004
    Inventors: Youssef L. Bennani, William H. Bunnelle, Sou-Jen Chang, Sanjay R. Chemburkar, Jinhua Chen, Michael J. Dart, Dilinie P. Fernando, Yi-Yin Ku, Mark Lockwood, Lei Wang
  • Process for preparing amine-substituted benzofurans
    Publication number: 20040054185
    Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
    Type: Application
    Filed: July 2, 2003
    Publication date: March 18, 2004
    Inventors: Marlon D. Cowart, Yu-Ming Pu, Yi-Yin Ku, Timothy A. Grieme, Ashok K. Gupta, Daniel J. Plata, Ramin Faghih, Gregory A. Gfesser
  • Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno [3,4-F] quinolines and derivatives thereof
    Patent number: 6673930
    Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: January 6, 2004
    Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald
  • Process for the preparation of chiral glucocorticoid receptor agents
    Patent number: 6608216
    Abstract: The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: August 19, 2003
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, Tim Grieme, Howard E. Morton, Steven A. King
  • Process for the preparation of chiral glucocorticoid receptor agents
    Publication number: 20030073844
    Abstract: The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.
    Type: Application
    Filed: June 28, 2002
    Publication date: April 17, 2003
    Inventors: Yi-Yin Ku, Tim Grieme, Howard E. Morton, Steven A. King
  • Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof
    Publication number: 20030069427
    Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.
    Type: Application
    Filed: November 7, 2002
    Publication date: April 10, 2003
    Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald