Abstract: A process for preparing contact lens with film by plasma UV induced grafting polymerization is disclosed to plasma-modification on contact lens to form hydrophilic functional groups on said contact lens surface, and then to immerse said contact lens in a solution of the mixture of NVP, PEGMA and photoinitiator, and then remove said contact lens from said solution and expose said contact lens to an ultraviolet light from an ultraviolet device to form a thin film on said contact lens surface. Through the thin film, the contact lens can have good hydrophilicity and anti-fouling properties, so when the patient wear said contact lens, he or she does not feel uncomfortable foreign body sensation, significantly reducing deposit and corneal infection risk.