Patents by Inventor Yian-Biao Zhang

Yian-Biao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Facilitating protein solubility by use of peptide extensions
    Patent number: 8535908
    Abstract: Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: September 17, 2013
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Paul I. Freimuth, Yian-Biao Zhang, Jason Howitt
  • Facilitating Protein Solubility by Use of Peptide Extensions
    Publication number: 20100144029
    Abstract: Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.
    Type: Application
    Filed: January 8, 2010
    Publication date: June 10, 2010
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Paul I. Freimuth, Yian-Biao Zhang, Jason Howitt
  • Facilitating protein folding and solubility by use of peptide extensions
    Publication number: 20030134352
    Abstract: Disclosed herein are novel compositions and methods for enhancing the solubility and promoting the adoption of native folding conformation of a protein or polypeptide expressed by recombinant DNA techniques. One embodiment of the present invention relates to a protein or polypeptide of interest is modified through either carboxyl- or amino-terminal peptide extension, so as to promote folding within host cells. Another embodiment relates to a method for enhancing the in vitro renaturation of a protein or polypeptide of interest expressed by recombinant DNA techniques, in circumstances where, following expression, a substantial percentage of the expressed protein or polypeptide of interest is localized within inclusion bodies.
    Type: Application
    Filed: January 4, 2002
    Publication date: July 17, 2003
    Inventors: Paul I. Freimuth, Yian-Biao Zhang, Jason A. Howitt