Patent number: 6274596
Abstract: Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is:
X is selected from the group consisting of O, S, CH2, CH2-CH2, C═O or NRB;
Y is C or N;
R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alky, alkenyl, alkynyl, alkoxy or acyl;
X-RA and R3, or R3 and R4, are optionally linked together to form a C3-C4 alkylene bridge, where X is CH2 or C═O; provided that:
when X is NRB, then
(a) RB is hydrogen, and RA is a linear or branched chain lower alkyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl optionally interrupted by at least one heteroatom, said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl being optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, alkenyl, alkynyl, acyl, alkoxy, or cycloalkyl optionally interrupted by at least one heter
Type:
Grant
Filed:
October 6, 1999
Date of Patent:
August 14, 2001
Assignee:
Anadys Pharmaceuticals, Inc.
Inventors:
Kelvin Lam, Vincent Boyd, Yi Bin Xiang
Patent number: 6194399
Abstract: Disclosed are pharmaceutical compositions and formulations comprising the compound:
wherein:
(a) R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, or optionally substituted alkyl, aryl, vinyl, alkyl(aryl), vinyl(aryl), amine, amide; or at least one of R1 and R2, together, and R3 and R4, together, form an optionally substituted ring system, wherein the ring system is optionally interrupted by at least one heteroatom;
(b) X is hydrogen, NO2, CN, halogen, OH, SO2, alkyl, alkoxy, or vinyl; and
(c) wherein when R1, R2, R3, and R4 are alkyl, aryl, vinyl, alkyl(aryl), vinyl(aryl), amine or amide, R1, R2, R3, and R4 are optionally interrupted with at least one heteroatom, or a salt thereof; and a pharmaceutically acceptable carrier or diluent. Also disclosed are methods of inhibiting microbial replication and treating microbial infections, comprising administration of a pharmaceutical composition or formulation of the invention.
Type:
Grant
Filed:
October 6, 1999
Date of Patent:
February 27, 2001
Assignee:
Scriptgen Pharmaceuticals, Inc.
Inventors:
Kelvin Lam, Yi Bin Xiang