Abstract: A system comprises chunking logic that chunks (or splits) a multiple sequence alignment (MSA) into chunks, first attention logic that attends to a representation of the chunks and produces a first attention output, first aggregation logic that produces a first aggregated output that contains those features in the first attention output that correspond to masked residues in the plurality of masked residues, mask revelation logic that produces an informed output based on the first aggregated output and a Boolean mask, second attention logic that attends to the informed output and produces a second attention output based on masked residues revealed by the Boolean mask, second aggregation logic that produces a second aggregated output that contains those features in the second attention output that correspond to masked residues concealed by the Boolean mask, and output logic that produces identifications of the masked residues based on the second aggregated output.

Abstract: The technology disclosed relates to accessing a multiple sequence alignment that aligns a query residue sequence to a plurality of non-query residue sequences, applying a set of periodically-spaced masks to a first set of residues at a first set of positions in the multiple sequence alignment, and cropping a portion of the multiple sequence alignment that includes the set of periodically-spaced masks at the first set of positions, and a second set of residues at a second set of positions in the multiple sequence alignment to which the set of periodically-spaced masks is not applied. The first set of residues includes a residue-of-interest at a position-of-interest in the query residue sequence.

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advises and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: The present invention provides new pyrazol-[1,5-a]-pyrimidone derivates and pharmaceutical compositions comprising said compounds and one or more pharmaceutically acceptable carriers or diluents. The uses of the compounds for the manufacture of potassium channel openers, anti-epilepsy medicaments, anti-anxiety medicaments and analgesic medicaments are also provided in the present invention.

Abstract: The present invention relates to a method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by the use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts. The present invention also relates to methods of conducting an N-dimensional NMR experiment in a phase-sensitive manner by the use of dual forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure secondary phase shifts or at least partially cancel dispersive and quadrature image signal components arising in the frequency domain from secondary phase shifts.

Abstract: The present invention provides new pyrazolo-[1,5-a]-pyrimidone derivates and pharmaceutical compositions comprising said compounds and one or more pharmaceutically acceptable carriers or diluents. The uses of the compounds for the manufacture of potassium channel openers, anti-epilepsy medicaments, anti-anxiety medicaments and analgesic medicaments are also provided in the present invention.

Abstract: The present invention relates to a method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by the use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts. The present invention also relates to methods of conducting an N-dimensional NMR experiment in a phase-sensitive manner by the use of dual forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure secondary phase shifts or at least partially cancel dispersive and quadrature image signal components arising in the frequency domain from secondary phase shifts.

Abstract: The present invention describes novel transcriptional activators and activation systems. The activators of the present invention comprise a DNA binding moiety linked to a short peptide of novel sequence. Preferably, the peptide is substantially hydrophobic. Preferred peptides include at least one aromatic amino acid. The present invention also provides improved transcriptional activation systems, useful for the identification and characterization of protein—protein interactions. The invention also describes the production and use of certain TBP mutants that enhance transcriptional activation by some activators.

Abstract: The present invention describes novel transcriptional activators and activation systems. The activators of the present invention comprise a DNA binding moiety linked to a short peptide of novel sequence. Preferably, the peptide is substantially hydrophobic. Preferred peptides include at least one aromatic amino acid. The present invention also provides improved transcriptional activation systems, useful for the identification and characterization of protein-protein interactions. The invention also describes the production and use of certain TBP mutants that enhance transcriptional activation by some activators.