Abstract: The present disclosure provides methods and compositions for the treatment of cancer using an ACAT1 inhibitor in combination with an immune checkpoint inhibitor. The immune checkpoint inhibitor may inhibit the programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation protein 3 (LAG-3), or combinations thereof. The ACAT1 inhibitor may be avasimibe, pactimibe, or purpactins, without limitation.

Abstract: The present invention relates to a method of producing a Mo—Cu alloy, comprising the following steps: (1) providing dispersed molybdenum powder, (2) producing a molybdenum skeleton with said dispersed molybdenum powder in step (1), (3) infiltrating said molybdenum skeleton in step (2) with copper and said Mo—Cu alloy is obtained; wherein said dispersed molybdenum powder has (D90?D0)/D50 of less than or equal to 2.1. The present invention also relates to a Mo—Cu alloy, a Mo—Cu alloy sheet, a method of producing a CPC laminated composite material and a CPC laminated composite material.

Abstract: Treatments of molecules with organic chemicals or bipolar reagents are used to enhance the interactions among or between molecules such as binding between proteins and antibodies or between nuclear acids. Such organic chemicals or bipolar reagents include alcohols, detergent, ester and ether. Treatments of molecules with the organic chemicals or bipolar reagents can take place before or during interactions among or between molecules. Enhancing intensities are about 2 to 100 times depending on molecules, organic chemicals or bipolar reagents and timing to treat molecules.

Abstract: The present invention is useful in taking a visible light image for identification and other purposes without the requirement of a photobooth, regardless of the background of the visible light image. The original background of the visible light image is replaced with a preselected background. Two IR images with different intensities of IR illumination in the foreground and background regions of the scene, respectively, are compared to produce a difference image of light intensity differences between corresponding pixels of the two images. A binarized image is generated by binarizing the difference image with respect to a predetermined threshold value .theta.. A connectivity constraint is used to generate a binary mask from the binarized image, then a gray-scale mask is produced by multiplying the binary mask times a preselected modulation function of the difference image. Warping the gray-scale mask produces a transformed mask.

Abstract: A method or system for structuring an image which corresponds to an original array of pixels, as a forward discrete even cosine transform (DCT) pyramid having a predetermined number of levels where each level is associated with a different DCT frequency band, includes, respectively, the steps or functionality of: partitioning the original array into blocks of overlapped pixels; taking a DCT of each block of overlapped pixels to generate blocks of first level DCT coefficients forming a first level of the DCT pyramid; storing the first level of the DCT pyramid; selecting and storing at least one of the first level DCT coefficients of each block of first level DCT coefficients into a first temporary array; partitioning the first temporary array into blocks of overlapped coefficients; and taking a DCT of each block of overlapped coefficients of the first temporary array to generate blocks of second level DCT coefficients forming a second level of the DCT pyramid.

Abstract: The invention relates to a novel process and system for removing noise from an image by first noise modeling an image signal source to generate noise masks and LUT values characteristic of noise at different frequency levels for each channel, and then applying the stored noise masks and LUT values to an image signal for noise removal. The image is first captured as an electronic image signal by the image signal source, then represented by a pyramid structure whereby each successive level of the pyramid is constructed from DC values of the previous level, and each level of the pyramid corresponds to a different frequency band of the image signal. A Wiener variant filter using DCT transforms is used to filter DCT coefficients at each level. The image is restored with reduced noise by replacing DC values with next level IDCT coefficients then performing an IDCT on the results.

Abstract: The image processing system of the present invention provides electronic edge detection in keeping with ISO/JPEG/MPEG international compression standards for electronic imaging. Specifically, a novel electronic image processing system for edge detection includes: an image acquisition device for acquiring and representing an image as an electronic image signal; a video memory for storing the image signal; a display for displaying the image signal; a raster to block converter for converting the image signal into block format; a DCT/IDCT processor for transforming the converted signal in accordance with predetermined basis matrices stored in a basis matrix memory; a mask multiplier for generating a mask multiplied signal in accordance with predetermined Laplacian matrices stored in an A matrix memory; a buffer for storing the mask multiplied signal; and a controller for controlling the image processing system in accordance with instructions from a central processing unit (CPU).

Abstract: The present invention is useful in taking images for identification and other purposes without the requirement of a photobooth, regardless of the background of the image. The original background of the image is replaced with a preselected background. Two IR images with different intensities of IR illumination in the foreground and background regions of the scene, respectively, are compared for light intensity differences between corresponding pixels of the two images to form a mask differentiating between the foreground and background regions of the image. The mask is then applied to a visible light image of the scene and the preselected background is used to replace the original background.