Patents by Inventor Yibo Ling

Yibo Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Implantable Dissolved Oxygen Sensor and Methods of Use
    Publication number: 20210030321
    Abstract: A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
    Type: Application
    Filed: October 7, 2020
    Publication date: February 4, 2021
    Inventors: Vincent Hok Liu, Christophoros Christou Vassiliou, Yibo Ling, Michael J. Cima
  • Implantable dissolved oxygen sensor and methods of use
    Patent number: 10806383
    Abstract: A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: October 20, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Vincent Hok Liu, Christophoros Christou Vassiliou, Yibo Ling, Michael J. Cima
  • Implantable magnetic relaxation sensors and methods of measuring a sensor's cumulative exposure to a biomarker
    Patent number: 9918656
    Abstract: An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: March 20, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Michael J. Cima, Paul Huang, Yibo Ling, Terrence Pong, Christophoros C. Vassiliou
  • IMPLANTABLE MAGNETIC RELAXATION SENSORS AND METHODS OF MEASURING A SENSOR'S CUMULATIVE EXPOSURE TO A BIOMARKER
    Publication number: 20130150707
    Abstract: An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.
    Type: Application
    Filed: June 27, 2011
    Publication date: June 13, 2013
    Applicants: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Michael J. Cima, Paul Huang, Yibo Ling, Terrence Pong, Christophoros C. Vassiliou
  • Implantable Dissolved Oxygen Sensor and Methods of Use
    Publication number: 20130046164
    Abstract: A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
    Type: Application
    Filed: May 4, 2011
    Publication date: February 21, 2013
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Vincent Hok Liu, Christophoros Christou Vassiliou, Yibo Ling, Michael J. Cima
  • Controlled Release of a Curing Agent for the Generation of Microstructures
    Publication number: 20080102276
    Abstract: A controlled release fabrication process includes shaping a precursor material into a desired configuration with a mold, supplying a curing agent from the mold to the precursor material, curing the precursor material to form a mechanically stable structure, and releasing the mechanically stable structure from the mold. Mechanically stable structures including microfabrication articles produced using the process are also described.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 1, 2008
    Inventors: Ali Khademhosseini, Giovanni Franzesi, Bin Ni, Yibo Ling