Abstract: The present invention relates to methods for treating patients with cancer, including patients with hematological malignancy, wherein the method comprises administering to the patient a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.

Abstract: The present invention relates to a method for removing protein corona on the surface of nanometer particle. Specifically, the invention provides a method for removing protein corona of protein corona modified nanometer particle, the method comprises the following steps: subjecting the protein corona modified nanometer particle to ultrasound stimulation to remove the protein corona of the protein corona modified nanometer particle; the nanometer particle comprises perfluoropentane. Ultrasound stimulation can remove protein corona on the surface of nanometer particle, overcome the masking effect of the protein corona on the ligand modified on the surface of nanometer particle, and prevent the protein corona from blocking the binding of the ligand modified on the surface of nanometer particle to cell receptor.

Abstract: A user interface facilitates a user designing one or more logging pipelines that may run concurrently on a computer system for logging information relative to one or more respective application. Custom object instances that run in a POD facilitate translating the applications’ formats, protocols, and rules for use by generic logging function components selected by the user when designing the pipelines. The custom object instances facilitate updates to a given pipeline being implemented without affecting other active pipelines that are logging application activity.

Abstract: The present application provides a seafloor multi-wave seismic source including: a pressure chamber mechanism; a high-voltage pulse generator with four discharge pathways; a thrust mechanism with a thrust rod and a thrust head; four vibrators are evenly distributed around a periphery of the thrust head, and each vibrator is connected with one discharge pathway of the high-voltage pulse generator; a power supply unit to power the seismic source; and a processor, a memory and a program, wherein the program is stored in the memory and configured to be executed by the processor; and the program includes: pulse emission instructions generated by the processor based on user settings and received by the high-voltage pulse generator, for switching on four or any two of the four discharge pathways at the same time, to enable the corresponding vibrators to vibrate to excite seismic waves in compression wave mode or shear wave mode.

Abstract: Embodiments of the present disclosure provide a method, device, and computer program product for managing index tables. There is provided a method of managing index tables, comprising: determining the number of indexing requests for documents, the indexing requests being received within a predetermined period of time; obtaining information related to a processing index table in an index processing system, the processing index table being used for storing indices generated based on the indexing requests, the index processing system further comprising a receiving index table, the receiving index table being used for storing at least a part of the indices in the processing index table; and adjusting, based on the number of indexing requests and the obtained information, the number of processing index tables in the index processing system.

Abstract: A method for predicting impedance of a voltage source converter under variable operating points is disclosed, pertaining to the field of analysis of small signal stability in an electrical power system. When the parameters and topology of the control system are fully unknown, the theoretical expression of impedance cannot be applied to a voltage source converter, and impedance is highly dependent on operating points. A fully decoupled impedance model disclosed is constructed in this disclosure.

Abstract: The present application provides a seafloor multi-wave seismic source including: a pressure chamber mechanism; a high-voltage pulse generator with four discharge pathways; a thrust mechanism with a thrust rod and a thrust head; four vibrators are evenly distributed around a periphery of the thrust head, and each vibrator is connected with one discharge pathway of the high-voltage pulse generator; a power supply unit to power the seismic source; and a processor, a memory and a program, wherein the program is stored in the memory and configured to be executed by the processor; and the program includes: pulse emission instructions generated by the processor based on user settings and received by the high-voltage pulse generator, for switching on four or any two of the four discharge pathways at the same time, to enable the corresponding vibrators to vibrate to excite seismic waves in compression wave mode or shear wave mode.

Abstract: Information processing is disclosed. For instance, a first polling interval between a current polling operation and a previous polling operation is polled, the first polling interval indicating a time period from an end of the previous polling operation to a start of the current polling operation. An execution status of the current polling operation is obtained, the execution status indicating whether an object to be polled for the current polling operation is obtained. Further, based on the first polling interval and the execution status, a second polling interval is determined between the current polling operation and the next polling operation, the second polling interval indicating a time period from an end of the current polling operation to a start of the next polling operation. In this way, the solution can provide a stable and efficient adaptive polling.

Abstract: Data stream processing is performed. For instance, a method includes: in response to a query request on an input data stream, determining data labels for input data items in the input data stream, the data labels at least indicating a first matching relationship between the input data items and a first query condition of the query request; determining an output data stream corresponding to the input data stream, the output data stream including output data items corresponding to the input data items, and each output data item having a data label; and determining query information corresponding to the query request based on the output data stream. In this way, it is possible to respond to real-time query requests for data streams.

Abstract: A method for predicting impedance of a voltage source converter under variable operating points is disclosed, pertaining to the field of analysis of small signal stability in an electrical power system. When the parameters and topology of the control system are fully unknown, the theoretical expression of impedance cannot be applied to a voltage source converter, and impedance is highly dependent on operating points. A fully decoupled impedance model disclosed is constructed in this disclosure.

Abstract: Data stream processing is performed. For instance, a method includes: in response to a query request on an input data stream, determining data labels for input data items in the input data stream, the data labels at least indicating a first matching relationship between the input data items and a first query condition of the query request; determining an output data stream corresponding to the input data stream, the output data stream including output data items corresponding to the input data items, and each output data item having a data label; and determining query information corresponding to the query request based on the output data stream. In this way, it is possible to respond to real-time query requests for data streams.

Abstract: The present disclosure relates to a method, device and computer program product for managing an address mapping of a storage system. A group of data objects in the storage system are mapped to a group of buckets in the address mapping, the group of buckets being divided into a first group of active shards which are associated with a group of storage devices in the storage system, respectively. In the method, a first write request for writing a first data object to the storage system is received. The address mapping is updated so as to map the first data object to a first bucket in the group of buckets. The storage system is instructed to store the first data object to a first storage device in the group of storage devices, and the first storage device is associated with a first active shard to which the first bucket belongs. The storage system is managed based on the updated address mapping.