Abstract: The boundary flow path is constituted of a pair of boundary wall surfaces facing each other in a first cross section intersecting each of the first flow path, the boundary flow path, and the second flow path. An inclination of a tangent to at least one of the pair of boundary wall surfaces is continuously changed. In a second cross section perpendicular to a direction in which coolant flows, a lateral width of the first flow path is larger than a longitudinal width of the first flow path and a lateral width of the second flow path is larger than a longitudinal width of the second flow path when a longitudinal direction represents a direction in which the pair of boundary wall surfaces face each other and a lateral direction represents a direction perpendicular to the longitudinal direction.

Abstract: The disclosure provides an anti-aging method. The method includes applying JWA gene to produce or screen anti-aging products, or products associated with treatment of aging-related diseases, or anti-oxidation products, or products for maintaining homeostasis, or products associated with diagnosis of aging or aging-related diseases, or agonists of the JWA gene.