Abstract: Related is a single-domain antibody targeting 4-1BB, a fusion protein thereof, a pharmaceutical composition and a use thereof. Specifically, the related single-domain antibody comprises one heavy chain variable region, and the amino acid sequences of CDR1-CDR3 contained in the heavy chain variable region are as shown in any item in table B, respectively. The single-domain antibody can bind to human 4-1BB and at the same time cross-bind to cynomolgus 4-1BB; in addition, with the help of external cross-linking, T cells are activated, which have excellent anti-tumor activity and safety.

Abstract: Provided are an anti-CAIX single-domain antibody and a VHH chain thereof, as well as related coding sequence, expression vector and host cell; also provided are a production method for said CAIX single-domain antibody and an application thereof.

Abstract: The present invention provides a kind of an integrated sewage treatment equipment for paper mill, which belongs to the technical field of sewage treatment, includes a box body, and the box body is arranged a water injection gap on the upper part at one side, the bottom of the box body is connected with a drainage pipe, and a filter assembly is arranged inside the box body movably, and the inner wall of the box body is equipped with a limit component which provides guidance for the movement of the filter assembly; the filter assembly includes several concentrically arranged annular plates, and two adjacent groups of annular plates are connected by a netting. The bottom of the annular plate is equipped with a chemical dosing component, and the inner side of the innermost annular plate is equipped with an adapter sleeve.

Abstract: Provided is a complementary determining region (CDR) of a VHH chain of an anti-PD-L1 single-domain antibody, wherein the CDR of the VHH chain includes the following: CDR1 with an amino acid sequence as shown in SEQ ID NO:5n+1; CDR2 with an amino acid sequence as shown in SEQ ID NO:5n+2, or CDR2 with an amino acid sequence having an sequence identity of greater than 85% with a sequence as shown in SEQ ID NO:2; and CDR3 with an amino acid sequence as shown in SEQ ID NO: 5n+3; wherein, each n is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15.

Abstract: The present invention relates to a coating composition, a coating method and use of the composition, and a product coated with the coating composition. The coating composition comprises: (a) an isocyanate-reactive component comprising: (a1) at least one polyaspartic ester, and (a2) optionally a polyetheraspartic ester; (b) an isocyanate component comprising: (b1) at least one isocyanate prepolymer having an isocyanate group equivalent of 300 to 1100, and (b2) at least one isocyanate oligomer containing not less than two isocyanate groups, the weight ratio of the isocyanate prepolymer (b1) to the isocyanate oligomer (b2) being from 1:4 to 4:1; (c) a catalyst; and (d) optionally an additive; wherein the coating composition has a molar ratio of isocyanate groups to isocyanate-reactive groups of 1.5:1 to 8:1. The coating composition provided by the present invention has a long pot life, and the resulting coating has the advantages of fast drying and high hardness.

Abstract: The present invention provides a kind of an integrated sewage treatment equipment for paper mill, which belongs to the technical field of sewage treatment, consists of a box body, and the said box body is arranged a water injection gap on the upper part at one side, the bottom of the box body is connected with a drainage pipe, and a filter assembly is arranged inside the said box body movably, and the inner wall of the box body is equipped with a limit component which provides guidance for the movement of the filter assembly; the said filter assembly consists of several concentrically arranged annular plates, and two adjacent groups of annular plates are connected by a netting. The bottom of the annular plate is equipped with a chemical dosing component, and the inner side of the innermost annular plate is equipped with an adapter sleeve.

Abstract: A non quenched and tempered steel and manufacturing process thereof. The process comprises a cooling step after the finish rolling step; and the process utilizes alternate intense cooling and moderate cooling. The intense cooling can ensure the surface temperature of the steel to decrease rapidly; and the moderate cooling allows the core temperature of the steel to dissipate gradually to the surface; a further intense cooling is carried out to allow rapid heat dissipation. The intense cooling and the moderate cooling can be carried out alternately several times according to practical requirement. A water cooling mode combining intense cooling and moderate cooling allows the core temperature and the surface temperature of the steel to become the same within a short time, and thus ensures the uniformity of the mechanical properties of the steel and improves the production efficiency.

Abstract: A non quenched and tempered steel and manufacturing process thereof. The manufacturing process of the non quenched and tempered steel has a cooling step after the finish rolling step, wherein intense cooling and moderate cooling are carried out alternatively. The intense cooling can ensure the surface temperature of the steel to decrease rapidly; and the moderate cooling allows the core temperature of the steel to dissipate gradually to the surface; a further intense cooling is carried out to allow rapid heat dissipation. The intense cooling and the moderate cooling can be carried out alternately several times according to practical requirement. A water cooling mode combining intense cooling and moderate cooling allows the core temperature and the surface temperature of the steel to become the same within a short time, and thus ensures the uniformity of the mechanical properties of the steel and improves production efficiency.

Abstract: A non quenched and tempered steel and manufacturing process thereof. The process comprises a cooling step after the finish rolling step; and the process utilizes alternate intense cooling and moderate cooling. The intense cooling can ensure the surface temperature of the steel to decrease rapidly; and the moderate cooling allows the core temperature of the steel to dissipate gradually to the surface; a further intense cooling is carried out to allow rapid heat dissipation. The intense cooling and the moderate cooling can be carried out alternately several times according to practical requirement. A water cooling mode combining intense cooling and moderate cooling allows the core temperature and the surface temperature of the steel to become the same within a short time, and thus ensures the uniformity of the mechanical properties of the steel and improves the production efficiency.

Abstract: A non-quenched and tempered steel and manufacturing process thereof. The process alters the cooling mode before finish rolling in previous production of non-quenched and tempered steel; the process at least has a cooling step after the finish rolling step; the process utilizes alternate intense cooling and moderate cooling. The intense cooling can ensure the surface temperature of the steel to decrease rapidly; and the moderate cooling allows the core temperature of the steel to dissipate gradually to the surface; a further intense cooling is carried out to allow rapid heat dissipation. The intense cooling and the moderate cooling can be carried out alternately several times accordingly. A water cooling mode combining intense cooling and moderate cooling allows the core temperature and the surface temperature of the steel to become the same within a short time, the uniformity of the mechanical properties of the steel.

Abstract: A process for producing a non quenched and tempered steel. The process comprises a cooling step at least after a finish rolling step. In said cooling step, an intense cooling and a moderate cooling are carried out alternately to allow the steel to undergo at least two stages of water cooling, so that the core temperature and the surface temperature of the steel become the same within a specified time, and thus ensures the uniformity of the mechanical properties of the steel and improves the production efficiency.