Patents by Inventor Yigael Gozlan

Yigael Gozlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphic forms of nateglinide
    Patent number: 7420084
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, 0, P, Q, T, U, V, Y, ?, ?, ?, ?, ?, ?, ? and ?, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: September 2, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome, Shlomit Wizel
  • Polymorphic forms of nateglinide
    Patent number: 7148376
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, ?, ?, ?, ?, ?, ?, ? and ?, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: December 12, 2006
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome
  • Polymorphic forms of nateglinide
    Publication number: 20050075400
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, ?, ?, ?, ?, ?, ?, ? and ?, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Application
    Filed: July 18, 2003
    Publication date: April 7, 2005
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome
  • Process for preparing nateglinide and intermediates thereof
    Patent number: 6861553
    Abstract: Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: March 1, 2005
    Assignee: Teva Pharmaceuticals Industries Ltd.
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan
  • Polymorphic forms of nateglinide
    Publication number: 20050014949
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, ?, ?, ?, ?, ?, ?, ? and ?, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 20, 2005
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome
  • Polymorphic forms of nateglinide
    Publication number: 20040181089
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, 0, P, Q, T, U, V, Y, &agr;, &bgr;, &ggr;, &dgr;, &egr;, &sgr;, &thgr; and &OHgr;, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Application
    Filed: July 18, 2003
    Publication date: September 16, 2004
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome
  • Process for preparing nateglinide and intermediates thereof
    Publication number: 20040152782
    Abstract: Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide.
    Type: Application
    Filed: July 3, 2003
    Publication date: August 5, 2004
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan
  • Polymorphic forms of nateglinide
    Publication number: 20040116526
    Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, &agr;, &bgr;, &ggr;, &dgr;, &egr;, &sgr;, &thgr; and &OHgr;, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.
    Type: Application
    Filed: July 18, 2003
    Publication date: June 17, 2004
    Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome