Patents by Inventor Yigal Becker

Yigal Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene
    Patent number: 11753417
    Abstract: Disclosed is a scalable process for preparation of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene (BCE), a key intermediate for manufacture of fragrance ingredient 3-methylcyclopentadecenone (MUSCENONE®) and analogs through reaction of 3-Methyl-1,5-cyclopentadecanedione (MCPD) and analogs with a metal or metalloid alkoxide in high yield and purity.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: September 12, 2023
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mohamad Gara, Yigal Becker
  • DIHYDROXYLATION OF OLEFINS USING OSMATE (VI) SALTS
    Publication number: 20220388931
    Abstract: A highly efficient synthesis of cis-diol compounds through cis-dihydroxylation of olefins using osmate (VI) salt as catalysts is disclosed, which has found important application in efficient large-scale preparation of, among others, ?,?-cedranediol from ?-cedrene.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 8, 2022
    Inventors: YIGAL BECKER, MOHAMAD GARA
  • SYNTHESIS OF 14-METHYL-16-OXABICYCLO[10.3.1]HEXADEC-12-ENE
    Publication number: 20220127278
    Abstract: Disclosed is a scalable process for preparation of 14-methyl-16-oxabicyclo[10.3.1]hexadec-12-ene (BCE), a key intermediate for manufacture of fragrance ingredient 3-methylcyclopentadecenone (MUSCENONE®) and analogs through reaction of 3-Methyl-1,5-cyclopentadecanedione (MCPD) and analogs with a metal or metalloid alkoxide in high yield and purity.
    Type: Application
    Filed: January 16, 2020
    Publication date: April 28, 2022
    Inventors: Mohamad Gara, Yigal Becker
  • Stereoselective synthesis of perhydro-3,6-dialkyl-2-benzo[b]furanones and analogs
    Patent number: 10995080
    Abstract: Synthetic methods of preparing perhydro-3,6-dimethyl-2-benzo[b]furanones, in particular dihydromintlactone, and analogs through reaction of dehydrogenation of menthanediols and analogs with a base in the presence of (carbonylchlorohydrido[bis-(2-diphenylphosphinoethyl)amine]ruthenium(II) as catalyst in good stereoselectivity and yields under stereochemistry controlled conditions are disclosed.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 4, 2021
    Assignee: INTERNATIONAL FLAVOR & FRAGRANCES INC.
    Inventors: Yigal Becker, Michael Cheskis
  • STEREOSELECTIVE SYNTHESIS OF PERHYDRO-3,6-DIALKYL-2-BENZO[B]FURANONES AND ANALOGS
    Publication number: 20200377466
    Abstract: Synthetic methods of preparing perhydro-3,6-dimethyl-2-benzo[b]furanones, in particular dihydromintlactone, and analogs through reaction of dehydrogenation of menthanediols and analogs with a base in the presence of (carbonylchlorohydrido[bis-(2-diphenylphosphinoethyl)amine]ruthenium(II) as catalyst in good stereoselectivity and yields under stereochemistry controlled conditions are disclosed.
    Type: Application
    Filed: May 28, 2020
    Publication date: December 3, 2020
    Applicant: International Flavors & Fragrances Inc.
    Inventors: Yigal BECKER, Michael CHESIKS
  • Cyclopropanation of substituted alkenes
    Patent number: 10584080
    Abstract: Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: March 10, 2020
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mohamad Gara, Yigal Becker
  • Processes for the preparation of unsaturated malonates
    Patent number: 10358415
    Abstract: Disclosed is a process for preparing unsaturated malonates and/or their isomers. The process includes the step of reacting an aldehyde and a dialkyl malonate in the presence of a Lewis acid and a carboxylic acid thereby forming an unsaturated malonate.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: July 23, 2019
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Michael Cheskis, Yigal Becker
  • CYCLOPROPANATION OF SUBSTITUTED ALKENES
    Publication number: 20190177247
    Abstract: Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.
    Type: Application
    Filed: February 1, 2019
    Publication date: June 13, 2019
    Applicant: International Flavors & Fragrances Inc.
    Inventors: Mohamad Gara, Yigal Becker
  • Cyclopropanation of substituted alkenes
    Patent number: 10227269
    Abstract: Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 12, 2019
    Assignee: International Flavors & Fragances Inc.
    Inventors: Mohamad Gara, Yigal Becker
  • CYCLOPROPANATION OF SUBSTITUTED ALKENES
    Publication number: 20180170830
    Abstract: Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.
    Type: Application
    Filed: August 4, 2016
    Publication date: June 21, 2018
    Inventors: Mohamad GARA, Yigal BECKER
  • PROCESSES FOR THE PREPARATION OF UNSATURATED MALONATES
    Publication number: 20180105490
    Abstract: Disclosed is a process for preparing unsaturated malonates and/or their isomers. The process includes the step of reacting an aldehyde and a dialkyl malonate in the presence of a Lewis acid and a carboxylic acid thereby forming an unsaturated malonate.
    Type: Application
    Filed: March 11, 2016
    Publication date: April 19, 2018
    Inventors: Michael CHESKIS, Yigal BECKER
  • Preparation of D-histidine and derivatives thereof from L-histidine
    Patent number: 5496955
    Abstract: D-histidine and its derivatives are manufactured from L-histidine, by mixing L-histidine and tartaric acid with an aldehyde in acetic acid medium and thereafter precipitating D-histidine tartrate from the reaction mass. Pure D-histidine can then be recovered from the crude D-histidine tartrate.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: March 5, 1996
    Assignee: Bromine Compounds Limited
    Inventors: Yigal Becker, Yonit Assaf-Biran, Youval Shvo
  • Cyanohydrination process
    Patent number: 5187296
    Abstract: A process for the assymetric cyanohydrination of m- phenoxybenzaldehyde with HCN, using a catalytically effective amount of enantiomeric cyclo(phenylalanylhistidine) absorbed on a solid support comprising a nonionic polymer resin is described.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: February 16, 1993
    Assignee: Bromine Compounds Limited
    Inventors: Yigal Becker, Asher Elgavi, Youval Shvo
  • Cyanohydrination catalyst and process
    Patent number: 5057477
    Abstract: A catalyst for the asymmetric cyanohydrination of m-phenoxybenzaldehyde, comprises a catalytically effective amount of enantiomeric cyclo (phenylalanyl-histidine) adsorbed on a solid support comprising a non-ionic polymer resin.The catalyst is particularly useful as a catalyst in a process for the preparation of (s)-m-phenoxybenzaldehyde cyanohydrin, in which m-phenoxybenzaldehyde is reacted in a cyanohydrination solvent.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: October 15, 1991
    Assignee: Bromine Compounds Ltd.
    Inventors: Yigal Becker, Asher Elgavi, Youval Shvo
  • Production of 3,5,6-trichloropyridin-2 ol and novel intermediates thereof
    Patent number: 5017705
    Abstract: Novel aryl and heteroaryl 4-cyano-2,2,4-trichlorobutyrates are prepared by reacting a corresponding aryl or heteroaryl trichloroacetate with acrylonitrile in the presence of a catalyst. Also provided is a novel process for producing 3,5,6-trichloropyridin-2-ol comprising cyclization of an aryl or heteroaryl 4-cyano-2,2,4-trichlorobutyrate in an inert organic solvent at elevated temperatures, in the presence of anhydrous hydrogen chloride.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: May 21, 1991
    Assignee: Luxembourg Industries (Pamol) Ltd.
    Inventor: Yigal Becker