Patents by Inventor Yigal Koltin

Yigal Koltin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Essential fungal genes and their use
    Patent number: 6514715
    Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: February 4, 2003
    Assignee: Millenium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Victoria Gavrias
  • Essential fungal genes and their use
    Patent number: 6465198
    Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: October 15, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Victoria Gavrias
  • Essential fungal genes and their use
    Patent number: 6461826
    Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: October 8, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Victoria Gavrias
  • Essential fungal genes and their use
    Publication number: 20020142363
    Abstract: Abstract of the Disclosure Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Application
    Filed: July 23, 2001
    Publication date: October 3, 2002
    Applicant: Millennium Pharmaceutical, Inc.
    Inventors: Yigal Koltin, Victoria Gavrias
  • Essential fungal genes and their use
    Publication number: 20020119509
    Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs thereof, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Application
    Filed: July 23, 2001
    Publication date: August 29, 2002
    Applicant: Millennium Pharmaceuticals, Inc., a Massachusetts corporation
    Inventors: Yigal Koltin, Victoria Gavrias
  • Identification of eukaryotic growth-related genes and promoter isolation vector and method of use
    Patent number: 6291218
    Abstract: A polynucleotide encoding chitin synthase (CHS1), an enzyme essential for cell wall synthesis and yeast cell growth, is provided. A maltose responsive promoter (MRP) isolated using the promoter library of the invention is also described. The present invention also provides a vector for isolation of a eukaryotic regulatory polynucleotide, i.e., promoter. The vector is useful in the method of the invention which comprises identifying a eukaryotic regulatory polynucleotide, i.e., promoter region, by complementing the growth of an auxotrophic host cell containing the vector of the invention, which includes a promoter region operably linked to a promoterless auxotrophic gene. The vector is introduced into the host cell chromosome by targeted integration. Also provided is a library containing host cells having the vector of the invention integrated in the chromosome of the host cell.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: September 18, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Perry Riggle, Vicky Gavrias, Chris Bulawa, Kenneth R. Winter
  • Essential fungal genes and their use
    Patent number: 6280963
    Abstract: Disclosed are essential Aspergillus polypeptides and genes (AN97, AN17, AN80, and AN85), as well as homologs of, which can be used to identify antifungal agents for treating fungal infections such as aspergillosis.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: August 28, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Victoria Gavrias
  • Identification of eukaryotic growth-related genes and promoter isolation vector and method of use
    Patent number: 6251593
    Abstract: A polynucleotide encoding chitin synthase (CHS1), an enzyme essential for cell wall synthesis and yeast cell growth, is provided. A maltose responsive promoter (MRP) isolated using the promoter library of the invention is also described. The present invention also provides a vector for isolation of a eukaryotic regulatory polynucleotide, i.e., promoter. The vector is useful in the method of the invention which comprises identifying a eukaryotic regulatory polynucleotide, i.e., promoter region, by complementing the growth of an auxotrophic host cell containing the vector of the invention, which includes a promoter region operably linked to a promoterless auxotrophic gene. The vector is introduced into the host cell chromosome by targeted integration. Also provided is a library containing host cells having the vector of the invention integrated in the chromosome of the host cell.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: June 26, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Perry Riggle, Vicky Gavrias, Chris Bulawa, Kenneth R. Winter
  • Identification of eukaryotic growth-related genes and promoter isolation vector and method of use
    Patent number: 6020133
    Abstract: A polynucleotide encoding chitin synthase (CHS1), an enzyme essential for cell wall synthesis and yeast cell growth, is provided. A maltose responsive promoter (MRP) isolated using the promoter library of the invention is also described.The present invention also provides a vector for isolation of a eukaryotic regulatory polynucleotide, i.e., promoter. The vector is useful in the method of the invention which comprises identifying a eukaryotic regulatory polynucleotide, i.e., promoter region, by complementing the growth of an auxotrophic host cell containing the vector of the invention, which includes a promoter region operably linked to a promoterless auxotrophic gene. The vector is introduced into the host cell chromosome by targeted integration. Also provided is a library containing host cells having the vector of the invention integrated in the chromosome of the host cell.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: February 1, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Yigal Koltin, Perry Riggle, Vicky Gavrias, Chris Bulawa, Ken Winter
  • Identification of eukaryotic growth-related genes and promoter isolation vector and method of use
    Patent number: 5824545
    Abstract: A polynucleotide encoding chitin synthase (CHS1), an enzyme essential for cell wall synthesis and yeast cell growth, is provided. A maltose responsive promoter (MRP) isolated using the promoter library of the invention is also described.The present invention also provides a vector for isolation of a eukaryotic regulatory polynucleotide, i.e., promoter. The vector is useful in the method of the invention which comprises identifying a eukaryotic regulatory polynucleotide, i.e., promoter region, by complementing the growth of an auxotrophic host cell containing the vector of the invention, which includes a promoter region operably linked to a promoterless auxotrophic gene. The vector is introduced into the host cell chromosome by targeted integration. Also provided is a library containing host cells having the vector of the invention integrated in the chromosome of the host cell.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: October 20, 1998
    Assignee: Millennium Pharaceuticals, Inc.
    Inventors: Yigal Koltin, Perry Riggle, Vicky Gavrias, Chris Bulawa, Ken Winter