Patents by Inventor Yih-Ling Tzeng

Yih-Ling Tzeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • serogroup A capsular polysaccharide acetyltransferase, methods and compositions
    Patent number: 7883876
    Abstract: Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: February 8, 2011
    Inventors: David S. Stephens, Seshu K. Gudlavalleti, Yih-Ling Tzeng, Anup K. Datta, Russell W. Carlson
  • Neisseria mutants, lipooligosaccharides and immunogenic compositions
    Patent number: 7807181
    Abstract: Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (kpsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: October 5, 2010
    Assignee: Emory University
    Inventors: David S. Stephens, Yih-Ling Tzeng, Susu Zughaier, Shanta Zimmer
  • NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS
    Publication number: 20090208533
    Abstract: Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
    Type: Application
    Filed: November 20, 2007
    Publication date: August 20, 2009
    Applicants: University of Georgia Research Foundation, Inc., Emory University
    Inventors: David S. Stephens, Seshu K. Gudlavalleti, Yih-Ling Tzeng, Anup K. Datta, Russell W. Carlson
  • Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions
    Publication number: 20060073168
    Abstract: Provided are recombinant DNA molecules that do not occur in nature encoding an O-acetyltransferase, vectors that direct expression of an O-acetyltransferase, recombinant host cells which express an O-acetyltransferase, methods for recombinant production of an O-acetyltransferase, methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using a recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
    Type: Application
    Filed: August 11, 2005
    Publication date: April 6, 2006
    Inventors: David Stephens, Seshu Gudlavalleti, Yih-Ling Tzeng, Anup Datta, Russell Carlson