Abstract: A method for shale gas exploitation includes performing horizontal drilling operation on an area to be constructed, forming a crack around a horizontal drill hole wall by shaped charge perforation; expanding the crack around a horizontal hole hydraulic fracturing, and extracting methane gas after a fracturing fluid is discharged; after methane gas is reduced, performing in-situ combustion explosion fracturing on the methane involved in horizontal drilling; thereafter continuing to expand the crack in the horizontal drill hole such that methane continues to seep out, and continuing extracting methane; repeating combustion explosion fracturing and extraction operations, so as to increase combustion explosion cracking permeability, and greatly enhance the exploitation effect of shale gas. The method is suitable for fracturing reconstruction of unconventional oil and gas reservoirs such as shale gas reservoirs, coal seam gas reservoirs and tight sandstone gas reservoirs.

Abstract: In some examples, an embolization device includes multiple sections with three-dimensional non-helical structures when deployed at a vascular site. The multiple sections include a first section and one or more second sections that are smaller than the first section. The first section may have a deployed structure configured to anchor the device at a vascular site (e.g., a blood vessel) of a patient while each of the one or more second sections may be formed from loops that configured to pack and obstruct the vascular site. In some cases, the embolization device also includes a third section having a deployed configuration with multiple helical windings or loops is configured to anchor the embolization device at the vascular site.

Abstract: A system for providing a persona-driven and artificially-intelligent avatar is disclosed. The avatar may be utilized to represent an artificially-intelligent virtual assistant that may perform actions on behalf of a user, such as actions related to personal shopping for the user. Notably, the avatar may influence artificial intelligence algorithms supporting the functionality of the virtual assistant via quantifiable traits of a persona of the avatar. In particular, the quantifiable traits of the persona of the avatar may be utilized to range bound the controlling parameters of the algorithms such that the virtual assistant represented by the avatar performs actions that conform to the ranged-bounded controlling parameters. Metrics corresponding to the performance of the virtual assistant may be tracked, and the system may modify parameters of the virtual assistant based on the metrics so as to adjust future actions performed by the virtual assistant for the user.

Abstract: Provided is an alkynyl(hetero)aromatic compound having an inhibitory effect to protein tyrosine kinase, a pharmaceutical composition comprising same, preparation and usage thereof. Specifically, disclosed is an alkynyl(hetero)aromatic compound as shown in formula (I), wherein rings A, R1, R2, R3, R4, R5, L, and B are defined in the description, a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug or an isotopic variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases, such as anti-tumor.

Abstract: The present invention discloses a preprocessing and imputing method for structural data, comprising: step 1, querying the missing information of an original data, counting missing values, and obtaining a missing rate for the original data; step 2, based on the missing rate, performing listwise deletion on the original data, and then traversing the rows to generate corresponding dichotomous arrays, converting the arrays to the form of histogram, calculating the maximum rectangular area formed by the corresponding histogram, and then sorting all rectangular areas to obtain the maximum complete information matrix; step 3, using multiple imputation by chained equations, auto-encoders, or generative adversarial imputation networks to impute missing values on the original data.

Abstract: The present invention provides substituted pyrazole compounds, compositions containing same, and use thereof. The substituted pyrazole compounds comprise a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound represented by formula (I) can serve as a tissue selective androgen receptor modulator (SARM), particularly serving as a drug for treating prostate cancer and other AR-dependent conditions and diseases in which AR antagonism is desired.

Abstract: Provided are a crystal form of a free base or a pharmaceutically acceptable salt of (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-fluoropyrrolidin-1-yl)-5-(pyrazin-2-yl)nicotinamide (compound A), a preparation method therefor, and use of the compound in preparation of drugs for treating diseases mediated by Bcr-Abl kinase and mutants thereof, such as chronic granulocytic leukemia. Also provided are a method for preparing compound A, and a preparation containing compound A.

Abstract: The present disclosure relates to a system and a method for preparing carbon nanofiber and hydrogen through continuous microwave pyrolysis. The system includes four apparatus. The melting and feeding apparatus is to heat and melt feedstocks. The microwave pyrolysis apparatus is for catalytic pyrolysis and includes a feedstock inlet, a gas outlet and a carbon outlet. The gas purification and utilization apparatus is for hydrogen purification and residual gas separation, The power generation apparatus includes a generator and a small internal combustion engine utilizing residual gas as fuel, and the generated smoke is conveyed to the melting and feeding apparatus for feedstocks melting. According to the present disclosure, a poly-generation system for co-producing high-performance carbon materials and hydrogen through plastic wastes with greatly increased energy utilization rate is formed to solve the technical problems of low product yield and high energy consumption in traditional pyrolysis.

Abstract: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: wherein A, L, R1, R2, R3, and n are described herein.

Abstract: Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disclosed are an alkynyl (hetero) aromatic ring compound represented by formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug or an isotope variant thereof. The disclosed compounds may be used in the treatment and/or prevention of diseases associated with protein tyrosine kinase, such as in preventing tumors.

Abstract: An N-benzenesulfonylbenzamide compound represented by the formula (I), or a crystal form, a prodrug, pharmaceutically acceptable salts, a stereoisomer, a solvate or a hydrate thereof, a pharmaceutical composition containing same, and a use thereof as a Bcl-2 protein inhibitor for preparing a medicament for treatment of leukemia or a cancer.

Abstract: The present disclosure relates to a system and a method for preparing carbon nanofiber and hydrogen through continuous microwave pyrolysis. The system includes four apparatus. The melting and feeding apparatus is to heat and melt feedstocks. The microwave pyrolysis apparatus is for catalytic pyrolysis and includes a feedstock inlet, a gas outlet and a carbon outlet. The gas purification and utilization apparatus is for hydrogen purification and residual gas separation, The power generation apparatus includes a generator and a small internal combustion engine utilizing residual gas as fuel, and the generated smoke is conveyed to the melting and feeding apparatus for feedstocks melting. According to the present disclosure, a poly-generation system for co-producing high-performance carbon materials and hydrogen through plastic wastes with greatly increased energy utilization rate is formed to solve the technical problems of low product yield and high energy consumption in traditional pyrolysis.

Abstract: Provided are a substituted benzimidazole compound, and a composition comprising same and use thereof. The substituted benzimidazole compound is a compound represented by formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate or solvate compound, polymorph, stereoisomer, or isotopic variation thereof. The compound can be used for treating and/or preventing related diseases caused by MEK, such as hyperproliferative diseases, pancreatitis, kidney diseases, blastocyte implantation, and diseases related to vasculogenesis or angiogenesis.

Abstract: The present invention relates to a crystalline form of a free base of a compound of formula (A) (compound A) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and use of the compound in the preparation of a medicament for treating and/or preventing diseases mediated by ALK kinase and mutants thereof, such as cell proliferative diseases, inflammation, infections, immunological diseases, organ transplantation, viral diseases, cardiovascular diseases or metabolic diseases.

Abstract: A substituted amino heterocyclic carboxamide compound as represent by formula (?), or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvent compound, a crystal form, a stereoisomer or an isotopic variant of the compound, and a pharmaceutical composition thereof, and the use thereof as an FLT3/AXL kinase inhibitor for treating acute myelocytic leukemia.

Abstract: An antiviral nucleoside reverse transcriptase inhibitor compound as shown in formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form or an isotopic derivative of the compound. A preparation method therefor, a pharmaceutical composition thereof, and a use thereof in the preparation of a drug for treating and/or preventing viral infectious diseases, such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

Abstract: A macrocycle represented by formula (I) and a pharmaceutical composition comprising the macrocycle, or a crystalline form, pharmaceutically acceptable salt, hydrate or solvent compound, stereoisomer, prodrug, or isotopic variant of the macrocycle. The macrocycle and the composition thereof inhibit a protein kinase.

Abstract: Provided in the present invention are a substituted aromatic fused ring derivative, a composition comprising the compound, and the use thereof. The substituted aromatic fused ring derivative is a compound as shown as formula (I) or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound and the composition of the present invention can be used to treat various protein tyrosine kinase-mediated diseases or conditions.

Abstract: A substituted amino heterocyclic carboxamide compound as represent by formula (?), or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvent compound, a crystal form, a stereoisomer or an isotopic variant of the compound, and a pharmaceutical composition thereof, and the use thereof as an FLT3/AXL kinase inhibitor for treating acute myelocytic leukemia.