Abstract: A pin binding structure, an array substrate and a display panel. The pin binding structure comprises: a first pin group, comprising a plurality of first pins distributed at intervals in a first direction, the first pin being in a bent line structure having a first opening, and the first openings of the plurality of first pins in the first pin group having the same orientation; and a second pin group, comprising a plurality of second pins distributed at intervals in the first direction, the second pin being in a bent line structure having a second opening, the second openings of the plurality of second pins in the second pin group having the same orientation, and the orientation of the second openings of the second pins being the opposite of the orientation of the first openings of the first pins.

Abstract: The present disclosure relates to a backlight source device, a light guide plate, and a display device. The backlight source device according to an embodiment of the present disclosure includes a light guide plate, a light source and a plastic frame, the light source is provided at an end of the light guide plate and is opposite to a side wall of the light guide plate; the plastic frame is provided at least at an end of the light guide plate away from the light source, wherein a plurality of wedge-shaped recesses are provided at an end of a light emitting surface of the light guide plate away from the light source.

Abstract: The present disclosure relates to a backlight source device, a light guide plate, and a display device. The backlight source device according to an embodiment of the present disclosure includes a light guide plate, a light source and a plastic frame, the light source is provided at an end of the light guide plate and is opposite to a side wall of the light guide plate; the plastic frame is provided at least at an end of the light guide plate away from the light source, wherein a plurality of wedge-shaped recesses are provided at an end of a light emitting surface of the light guide plate away from the light source.

Abstract: The present disclosure provides an array substrate, a manufacturing method of an array substrate, and a display device. The array substrate includes: a base substrate; a first signal line, extending in a first direction and located on the base substrate; a second signal line, extending in a second direction and located on a side of the first signal line away from the base substrate and insulated with the first signal line, the first direction and the second direction crossing with each other. A side of the first signal line facing the second signal line is provided with a groove, the groove is located at a crossing region between the first signal line and the second signal line, in the crossing region, an otherographic projection of the second signal line on the base substrate completely falls into an orthographic projection of the groove on the base substrate.

Abstract: The present disclosure provides an array substrate, a manufacturing method of an array substrate, and a display device. The array substrate includes: a base substrate; a first signal line, extending in a first direction and located on the base substrate; a second signal line, extending in a second direction and located on a side of the first signal line away from the base substrate and insulated with the first signal line, the first direction and the second direction crossing with each other. A side of the first signal line facing the second signal line is provided with a groove, the groove is located at a crossing region between the first signal line and the second signal line, in the crossing region, an otherographic projection of the second signal line on the base substrate completely falls into an orthographic projection of the groove on the base substrate.

Abstract: A packaging box for display panels is provided. The packaging box comprises a box body having an opened end. A pair of opposite inner sidewalls of the box body is provided with a first holding component and a second holding component respectively, and each of the first holding component and the second holding component comprises at least one first recess and at least one second recess. A first distance between the bottom of one first recess of the first holding component and the bottom of one corresponding first recess of the second holding component is different from a second distance between the bottom of one second recess of the first holding component and the bottom of one corresponding second recess of the second holding component.

Abstract: The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.

Abstract: The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.

Abstract: A small molecular inhibitor of E2F (HLM006474) was identified using a computer-based virtual screen and the known crystal structure of the DNA bound E2F4/DP2 heterodimer. Treatment of multiple cell lines resulted in the loss of intracellular E2F4 DNA-binding activity. Overnight exposure to HLM006474 resulted in down regulation of total E2F4 protein as well as several known E2F targets. The effects of treatment on different cell lines included a reduction in cell proliferation and an increase in apoptosis. Apoptosis was induced in a manner distinct from cisplatin and doxorubicin. E2F4-null MEFs (mouse embryo fibroblasts) were less sensitive than wildtype counterparts to the apoptosis-inducing activity of the compound revealing its biological specificity. A375 cells were extremely sensitive to the apoptosis-inducing activity of the compound in two-dimensional culture and HLM006474 was a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system.

Abstract: A small molecular inhibitor of E2F (HLM006474) was identified using a computer-based virtual screen and the known crystal structure of the DNA bound E2F4/DP2 heterodimer. Treatment of multiple cell lines resulted in the loss of intracellular E2F4 DNA-binding activity. Overnight exposure to HLM006474 resulted in down regulation of total E2F4 protein as well as several known E2F targets. The effects of treatment on different cell lines included a reduction in cell proliferation and an increase in apoptosis. Apoptosis was induced in a manner distinct from cisplatin and doxorubicin. E2F4-null MEFs were less sensitive than wildtype counterparts to the apoptosis-inducing activity of the compound revealing its biological specificity. A375 cells were extremely sensitive to the apoptosis-inducing activity of the compound in two-dimensional culture and HLM006474 was a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system.