Patents by Inventor Yihua Liao
Yihua Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8946227Abstract: The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.Type: GrantFiled: January 30, 2013Date of Patent: February 3, 2015Assignee: Merck Serono SAInventors: Sharad Magar, Andreas Goutopoulos, Yihua Liao, Matthias Schwarz, Russell J. Thomas
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Publication number: 20140297740Abstract: In one embodiment, one or more computing devices access a social graph including nodes and edges between nodes; the nodes include user nodes corresponding to users of a social-networking system and concept nodes corresponding to concepts of the social-networking system; the computing devices identify first user nodes in the social graph corresponding to users having a particular user characteristic; the computing devices assign a characteristic score to each first user node; for a second user node without an assigned characteristic score, the computing devices also select neighboring user nodes connecting to the second user node based on affinity, and estimate a characteristic score for the second user node by aggregating iteratively characteristic scores while traversing the social graph from at least one first user node to the second user node through paths that each includes at least one selected neighboring node.Type: ApplicationFiled: March 27, 2013Publication date: October 2, 2014Inventors: Chandrasekher Narayanan, Sundhar Ram Srinivasan, Jeremy Hoon, Yihua Liao, Andrew Fabian Ledvina
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Publication number: 20130143893Abstract: The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.Type: ApplicationFiled: January 30, 2013Publication date: June 6, 2013Applicant: MERCK SERONO SAInventors: Sharad Magar, Andreas Goutopoulos, Yihua Liao, Matthias Schwarz, Russell J. Thomas
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Patent number: 8058305Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: GrantFiled: August 3, 2009Date of Patent: November 15, 2011Assignee: Merck Serono SAInventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
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Patent number: 7863312Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.Type: GrantFiled: May 14, 2008Date of Patent: January 4, 2011Assignee: Merck Serono SAInventors: Gian Luca Araldi, Yihua Liao, Adulla P. Reddy, Zhong Zhao
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Publication number: 20100305137Abstract: The invention provides 2-carboxamide piperazine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.Type: ApplicationFiled: June 2, 2010Publication date: December 2, 2010Applicant: MERCK SERONO SAInventors: Sharad Magar, Andreas Goutopulos, Yihua Liao, Matthias Schwarz, Russel J. Thomas
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Patent number: 7754722Abstract: The invention provides 2-carboxamide piperazine compounds of formula I, R3.IN\?N˜?R2I(0)z-oR4I wherein R?, R2, R3 and R4 are as defined in the claims and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for the treatment of mammalian infertility.Type: GrantFiled: September 19, 2003Date of Patent: July 13, 2010Assignee: Merck Serono SAInventors: Sharad Magar, Andreas Goutopoulos, Yihua Liao, Matthias Schwarz, Russell J. Thomas
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Patent number: 7635713Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: GrantFiled: November 21, 2007Date of Patent: December 22, 2009Assignee: Laboratoires Serono SAInventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
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Publication number: 20090292000Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: ApplicationFiled: August 3, 2009Publication date: November 26, 2009Applicant: LABORATOIRES SERONO S.A.Inventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
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Patent number: 7465755Abstract: The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.Type: GrantFiled: July 16, 2004Date of Patent: December 16, 2008Assignee: Laboratoires Serono SAInventors: Gian Luca Araldi, Yihua Liao, Nadia Brugger
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Publication number: 20080234346Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.Type: ApplicationFiled: May 14, 2008Publication date: September 25, 2008Applicant: LABORATOIRES SERONO S.A.Inventors: Gian Luca ARALDI, Yihua Liao, Adulla P. Reddy, Zhong Zhao
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Patent number: 7410991Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.Type: GrantFiled: October 23, 2002Date of Patent: August 12, 2008Assignee: Laboratoires Serono S.A.Inventors: Gian Luca Araldi, Yihua Liao, Adulla P. Reddy, Zhong Zhao
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Publication number: 20080114051Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteoporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: ApplicationFiled: November 21, 2007Publication date: May 15, 2008Applicant: LABORATOIRES SERONO S.A.Inventors: Yihua LIAO, Zhong Zhao, Gian Luca Araldi
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Patent number: 7335680Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: GrantFiled: December 19, 2002Date of Patent: February 26, 2008Assignee: Laboratoires Serono SAInventors: Yihua Liao, Zhong Zhao, Gian Luca Araldi
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Publication number: 20070185191Abstract: The present invention relates to hydrazide derivatives of Formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.Type: ApplicationFiled: July 16, 2004Publication date: August 9, 2007Applicant: Applied Research Systems ARS Holding N.V.Inventors: Gian Araldi, Yihua Liao, Nadia Brugger
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Publication number: 20050176800Abstract: Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.Type: ApplicationFiled: December 19, 2002Publication date: August 11, 2005Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.Inventors: Yihua Liao, Zhong Zhao, Gian Araldi
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Publication number: 20040254233Abstract: The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.Type: ApplicationFiled: April 16, 2004Publication date: December 16, 2004Inventors: Gian Luca Araldi, Yihua Liao, Adulla P. Reddy, Zhong Zhao