Abstract: A method and a system for parametric imaging in PET may be provided. Multiple PET images collected via a PET scan of a target subject may be obtained. The PET images may be dynamic PET images for difference time periods during the PET scan and used to generate a target PET parametric image of the target subject. Whether data correction needs to be performed in a process of generating the target PET parametric image may be determined. In response to determining that data correction needs to be performed, the PET images or a preliminary PET parametric image may be corrected, and the target PET parametric image of the target subject may be generated based on the corrected PET images or the corrected preliminary PET parametric image, wherein the preliminary PET parametric image is generated by processing the PET images using at least one pharmacokinetic model.

Abstract: The present disclosure provides systems and methods for motion correction of a positron emission computed tomography (PET) image. The method may include: obtaining scanned images of a scanned object generated at a plurality of time points; and determining a parametric image by performing a correction processing on the scanned images, wherein the correction processing may be configured to correct an influence of a motion of the scanned object on the scanned images.

Abstract: The present disclosure provides systems and methods for image generation. The methods may include obtaining a first medical image and a second medical image of a target subject. The first medical image may be generated based on first scan data collected using a first imaging modality, and the second medical image may be generated based on second scan data collected using a second imaging modality. The methods may include generating a pseudo-second medical image by transforming the first medical image. The pseudo-second medical image may be a simulated image corresponding to the second imaging modality. The methods may further include determining registration information between the first medical image and the second medical image based on the second medical image and the pseudo-second medical image.