Abstract: A nasal aspirator includes a housing assembly, a negative pressure assembly and a guide assembly. A negative pressure cavity and a treatment cavity are arranged in the housing assembly at intervals, the treatment cavity is sequentially divided into a first cavity chamber and a second cavity chamber by a partition plate, and the first cavity chamber is communicated with the second cavity chamber; the negative pressure assembly is arranged in the negative pressure cavity and is formed with a suction pipeline and a discharge pipeline which are communicated with a side wall surface of the housing assembly; the guide assembly comprises a first guide piece and a second guide piece, and the first guide piece is detachably connected with the side wall surface of the housing assembly; and the second guide piece is fixedly connected to the side wall surface of the housing assembly.

Abstract: Light-based visual cues may be provided, for example to assist a patient in proper use of a medication delivery device, such as a medication injection device or a medication storage container. A light source, such as an organic light-emitting diode (OLED), may be used, which, when activated, may be a visual cue to perform a medication delivery instruction and/or may illuminate medication delivery information. Some example instructions may be to remove a cap of a medication delivery device or to shake the medication delivery device. A light sensor, motion sensor, microphone and/or other sensors may also be employed to trigger activation of the light source, based on detected light, motion and/or sound.

Abstract: The present disclosure relates to a drug delivery device, comprising a shell adapted to contain one of a plurality of medicament containers prefilled with different deliverable volumes of a medicament. The shell is transparent at least in an area adapted to contain the medicament container, and a label adapted to be arranged on the shell. The label comprises a foil having a first surface and a second surface, which is adapted to be connected to the shell. At least one cutout or transparent area is arranged in the foil adapted to be placed on the shell such that a medicament container arrangeable or arranged within the shell is visible through the cutout or transparent area. The cutout or transparent area exhibits a size adapted to allow inspection of the deliverable volume of medicament within the medicament container when the label is applied to the shell.

Abstract: The present invention relates to an auto-injector. The auto-injector includes a housing for receiving a syringe having a plunger, a needle, and a barrel containing a dose of medicament; a drive mechanism configured to, when triggered by a user, automatically drive the plunger from a first position to a second position to expel the dose from the barrel of the syringe through the needle at a front end of the auto-injector; a detector arrangement configured to detect a state of the plunger including at least departure from the first position and arrival at the second position; and an indicator arrangement comprising a display having one or more electrically-operated display elements and configured to provide, responsive to the detector arrangement detecting the departure of the plunger from the first position, a visual indication comprising cycles of indications, the cycles of indications repeating until the detector arrangement detects the arrival of the plunger at the second position.

Abstract: The present disclosure provides a sub-assembly of a medicament delivery device, the sub-assembly comprising: a tubular outer cap extending along a longitudinal axis, an inner cap at least partially surrounded by the tubular outer cap, and a clutch formed by a driving part and a driven part. The inner cap is configured to be removably attached to a housing of the medicament delivery device via a rotational attachment. The driven part is attached to the inner cap and positioned between the tubular outer cap and the inner cap in a direction transverse to the longitudinal axis. The outer cap is axially movable relative to the inner cap between a proximal position and a distal position. The tubular outer cap comprises the driving part extending from a body of the tubular outer cap. The driven part extending in the direction transverse to the longitudinal axis towards the tubular outer cap.

Abstract: In one example, an accessory for a drug injection device has a proximal end, a distal end, a receptacle, and a base. The receptacle defines a cavity that extends into the proximal end towards the distal end and terminates at an inner surface. The cavity receives an injection end of the drug injection device therein so as to position a needle of the drug injection device for delivery of a medication. The receptacle defines an opening that extends into the distal end and through the inner surface. The opening receives the needle of the drug injection device therethrough and has a cross-sectional dimension that is smaller than a cross-sectional dimension of the cavity. The base is disposed at the distal end of the injection device and has a skin-contacting surface with a cross-sectional dimension that is greater than the cross-sectional dimension of the cavity.

Abstract: A medical device assembly comprises a medical device, such as a urinary catheter, comprising an insertable part and a non-insertable part. The insertable part comprises an elongate shaft provided with a hydrophilic coating or surface. The assembly further comprises a wetting fluid compartment arranged to encircle at least a part of the medical device, and preferably at least a part of the non-insertable part, and an aqueous fluid arranged in the wetting fluid compartment. At least one of the aqueous fluid and the hydrophilic coating or surface comprises at least one surfactant. The hydrophilic coating or surface is maintained essentially separated from the aqueous fluid, and arranged to become wetted by movement of the elongate shaft through the wetting fluid compartment.

Abstract: Provided herein are vascular access devices having integrated safety features configured to prevent unintended migration of guidewires into a patient's body. Also provided are safety guidewires that provide a tactile and/or visual indicator of insertion length. Also provided are introducer sets including the same.

Abstract: An outer sheath for surrounding and covering components of a delivery device includes a straight section including an aperture extending fully through the straight section. The outer sheath further includes a pre-curved section extending distally from an end of the straight section and including an aperture extending fully through the pre-curved section. The straight section and the pre-curved section include a varying stiffness along a length of the straight section and the pre-curved section.

Abstract: This disclosure generally relates to devices for printing a graft onto a wound. In some embodiments, the devices comprise one or more reservoirs adapted to receive and/or contain a biological material or a synthetic material. The devices may further comprise a cooling component adjacent the reservoir configured to cool the internal portion of the one or more reservoirs at greater than or equal to ?30° C. and less than or equal to 10° C., according to other embodiments. In some embodiments, the device comprises a dispenser configured to dispense the biological and/or synthetic material onto a surface of the wound. In some embodiments, the device preserves the native structure of the biological and/or synthetic material after deposition. This disclosure also provides methods for printing a graft onto a wound e.g., using the devices contemplated herein.

Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.

Abstract: The present disclosure relates to microneedle particles and a method for preparing microneedle particles.

Abstract: A device for delivery of agent to a biological barrier may comprise a petal bearing main body having a set of guides each having an upstream and downstream portion. The device may further comprise a reservoir including at least one delivery sharp. The device may further comprise a plunger having a set of plunger protrusions each disposed in a respective guide. The device may further comprise a first bias member urging the plunger toward a position in which the protrusions are at an end of the downstream portions. The device may further comprise a trigger body with a first and second set of barriers. The trigger body may be displaceable between a position in which the second barriers are stowed and the first barriers obstruct displacement of the protrusions and another position in which the first barriers are stowed and the second barriers obstruct travel of the protrusions.

Abstract: The invention relates to methods and system for locally treating a wound (for example, ARDS) of a lung tissue, or mediastinum condition, comprising choosing a target in said tissue requiring treatment; insertion trans-bronchial catheter with mini-ultrasonic therapeutic transducers as close as possible to the target; calibrating contact, calibrating position and irradiating said target with therapeutic ultrasonic waves. Optionally, also providing treatment using phonophoresis and iontophoresis for local administration of drugs into the wound.

Abstract: A universal heart port, in various embodiments, comprises: a cylindrical heart port body defining a circular top surface, an outer surface, and a cylindrical opening that extends through the heart port body; and one or more adapter coupling flanges, each respective adapter coupling flange of the one or more adapter coupling flanges extending radially outward along at least a portion of the top surface of the heart port body and comprising a respective end stop portion that extends perpendicularly downward from a respective end portion of the respective adapter coupling flange. In some embodiments, each of the adapter coupling flanges are substantially evenly spaced about the outer surface of the heart port body. In some embodiments, the heart port further comprises one or more adapters configured for selective coupling to the heart port. The adapters may include a plug, a canula adapter, an LVAD adapter, etc.

Abstract: A cardiac assist device includes an expandable cup with a pumping chamber having at least one inflow aperture, an outflow nozzle in communication with the chamber, and a volume displacement member inside the chamber. The volume displacement member is cyclically movable between a low-volume state and a high-volume state at a frequency F, wherein a displacement volume of blood Vd is displaced from the chamber through the nozzle during each cycle. When the volume displacement member moves at frequency F, the device increases momentum of blood flowing through the device such that flow rate of blood exiting the nozzle is substantially greater than the frequency F multiplied by the displacement volume Vd. In some embodiments, the volume displacement member includes a balloon having a proximal region that is distanced from an inner wall of the chamber more than a distal region of the balloon when the balloon is fully inflated.

Abstract: Provided herein are methods for treating macular degeneration, age-related macular degeneration, and photoreceptor degeneration in a subject including delivering to the subject electrical stimulation in the form of a ramp waveform, wherein the electrical stimulation is delivered through the skin around the eye. The methods provide for electrical stimulation at least most days per week.

Abstract: A neuromodulation system includes an implantable neuromodulation device and an external unit. The neuromodulation device includes an electrode platform, a sensor/recorder coupled to the electrode platform, and a transceiver coupled to the sensor/recorder. The sensor/recorder senses electrical activity of tissue resulting from a delivery of a stimulation therapy to the tissue. The stimulation therapy is defined by a plurality of stimulation parameters, and the sensed electrical activity includes a stimulation response comprising an evoked stimulation response, a stimulation artifact, and an evoked compound action potential (ECAP) response. The transceiver transmits a sensed signal corresponding to the electrical activity.

Abstract: A system may include a neurostimulator. The neurostimulator may include a waveform generator configured to deliver neurostimulation, a controller operably connected to the waveform generator to control the neurostimulation, and an accelerometer. The controller may be configured to monitor an output of the accelerometer, detect an event from the output of the accelerometer, and perform a neurostimulator action in response to the detected event. The event may include at least one intentional user interaction with the neurostimulator or an unintended neurostimulator event.

Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which a stimulation location in an electrode array is determined. Preferably, the supra-perception stimulation comprises a bipole formed using actively-driven symmetric biphasic waveforms at active ones of the electrodes in the array. After determining the location, a perception threshold for the bipole at the location is determined and stored, and an amplitude of the stimulation is reduced below the perception threshold to provide a sub-perception stimulation bipole. The determined perception threshold may be used to compose one or more programs using stimulation amplitudes that are a percentage of the determined perception threshold. The one or more programs may run according to schedule. For example, the programs may be interleaved.