Patents by Inventor Yik Sham Clive Chung

Yik Sham Clive Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-ACRYLOYLINDOLES AND METHODS OF USE
    Publication number: 20240103005
    Abstract: The subject invention pertains to a new class of compounds, N-acryloylindole (NAIs), and methods of using NAIs as cysteine-reactive probes for proteome-wide cysteine profiling and imaging of thiol oxidative modifications. NAIs are capable of imaging oxidized thiols in cells facing oxidative stress by confocal fluorescence microscopy. NAIs can capture populations of cysteines, particularly those involved in gene expression and regulation.
    Type: Application
    Filed: April 27, 2023
    Publication date: March 28, 2024
    Inventors: Yik Sham Clive CHUNG, Hin Yuk LAI, Tin Yan KOO, Yui Yan Hillary YIP
  • PROBES FOR DETECTION OF COPPER
    Publication number: 20220196685
    Abstract: The present disclosure provides Forster resonance energy transfer (FRET)-based probes for detecting copper, e.g., for detecting Cu(I) in live cells. The present disclosure provides methods for detecting copper, e.g., for detecting Cu(I) in live cells, using a FRET-based probe of the present disclosure.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 23, 2022
    Inventors: Christopher J. Chang, Yik Sham Clive Chung, Sumin Lee
  • Gold porphyrin-PEG conjugates and methods of use
    Patent number: 11135310
    Abstract: Disclosed are conjugates, compositions, and methods that include or use one or more gold(III) porphyrin complexes. Preferred conjugates are gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. Preferred compositions and methods include or use such gold(III) porphyrin-PEG conjugates. Disclosed is a method for treatment of cancer comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. The gold(III) porphyrin-PEG conjugates can be in the form of nanostructures formed by self-assembly of the gold(III) porphyrin-PEG conjugates; or nanocomposites formed by encapsulation of other therapeutic agents by the nanostructures of gold(III) porphyrin-PEG conjugates.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 5, 2021
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Chi Ming Che, Yik Sham Clive Chung
  • PUROMYCIN-BASED PROBES AND METHODS OF USE THEREOF
    Publication number: 20210061842
    Abstract: The present disclosure provides puromycin-based probes, as well as compositions and kits comprising the probes. The present disclosure provides methods of detecting an analyte, and imaging methods, using the probes.
    Type: Application
    Filed: March 20, 2019
    Publication date: March 4, 2021
    Inventors: Christopher J. Chang, Yik Sham Clive Chung
  • mTORC1 modulators
    Patent number: 10807951
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 20, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel K. Nomura, Roberto Zoncu, Allison M. Roberts, Kelvin F. Cho, Yik Sham Clive Chung, Hijai Shin, Benjamin Croze
  • mTORC1 MODULATORS
    Publication number: 20190112268
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Inventors: Daniel K. Nomura, Roberto Zoncu, Allison M. Rpberts, Kelvin F. Cho, Yik Sham Clive Chung, Hijai Shin, Benjamin Croze
  • GOLD PORPHYRIN-PEG CONJUGATES AND METHODS OF USE
    Publication number: 20170157261
    Abstract: Disclosed are conjugates, compositions, and methods that include or use one or more gold(III) porphyrin complexes. Preferred conjugates are gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. Preferred compositions and methods include or use such gold(III) porphyrin-PEG conjugates. Disclosed is a method for treatment of cancer comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. The gold(III) porphyrin-PEG conjugates can be in the form of nanostructures formed by self-assembly of the gold(III) porphyrin-PEG conjugates; or nanocomposites formed by encapsulation of other therapeutic agents by the nanostructures of gold(III) porphyrin-PEG conjugates.
    Type: Application
    Filed: December 2, 2016
    Publication date: June 8, 2017
    Inventors: Chi Ming Che, Yik Sham Clive Chung