Abstract: A method and system for real-time calculating a microseismic focal mechanism based on deep learning is provided, which belongs to the technical field of microseismic monitoring. The method includes: creating a training dataset, the training data including simulated DAS microseismic strain data and a focal mechanism corresponding to the simulated DAS microseismic strain data; training a focal mechanism calculation model by using the training dataset, with the simulated DAS microseismic strain data as an input and the focal mechanism corresponding to the simulated DAS microseismic strain data as a target output, so as to obtain a trained focal mechanism calculation model; collecting DAS microseismic strain data by a surface and downhole DAS acquisition system; performing preprocess operations such as removing abnormally large values on the DAS microseismic strain data; inputting the preprocessed DAS microseismic strain data into a trained focal mechanism calculation model to obtain a focal mechanism.

Abstract: Embodiments of the present disclosure provide a multi-physical field imaging method based on PET-CT and DAS, comprising: wrapping distributed acoustic sensors on a surface of a non-metallic sample to be tested, and then placing them in a pressure device; loading triaxial pressures; preparing a tracer fluid; pumping the tracer fluid into the non-metallic sample; collecting PET images and CT images of internal structure of the non-metallic sample, meanwhile, monitoring internal acoustic emission events of the non-metallic sample in real time; combining the PET images with the CT images, to obtain PET/CT images; locating the acoustic emission events, and obtaining occurrence time and spatial location of internal structural perturbations; and analyzing a mechanism of fluid-solid coupling effect in the non-metallic sample under loaded stress. The imaging method and system of the present disclosure can accurately and reliably image the fluid-solid coupling process in the material.

Abstract: A client device may transmit a data stream including an object (such as a data file or record) to a storage system for storing the object in a storage device. In response to receiving the data stream, the storage system may store or write data of the object into a plurality of logical blocks of the storage device with an end-to-end data protection based at least in part on a comparison of a combination of check codes of a header of the object, the object and padding data with a combination of a plurality of check codes that are generated separately for metadata associated with the object and corresponding parts of the object stored in the plurality of logical blocks. The storage system may further provide an end-to-end data protection for reading data of an object stored in multiple logical blocks of a storage device.

Abstract: A seismometer with high sensitivity, broadband and all-dip is provided, The which relates to the technical field of seismometer, including a first force feedback module, an insulator, a top cover, a terminal post, an upper leaf spring, a mass block, a casing, a sealing ring, an insulation gasket, a guide spring, a wire frame, a magnetic shoe, a compensation ring, a lower leaf spring, a bottom cover, a second force feedback module and a third force feedback module. It provides the broadband seismometer technology based on dynamic force balance feedback and the all-dip broadband seismometer technology based on dip angle perception, which breaks through the limitations of conventional seismometers in sensitivity, frequency band, and dip angle, and truly realizes a seismometer with high sensitivity, broadband, and all-dip.

Abstract: A storage engine may be configured to receive data including a plurality of records from a client device, and generate a plurality of record headers for the plurality of records. The storage engine may then transfer a group of record headers of the plurality of record headers to a storage device to cause the storage device to store the group of record headers consecutively in a data sector of the storage device, and further transfer a subset of payload data of one or more records associated with the group of record headers to the storage device to cause the storage device to store the one or more records after the group of record headers in the data sector of the storage device.

Abstract: A storage engine may obtain one or more object access properties of an object to be received, and determine a type of storage device that is suitable or desirable for storing the object from among different types of storage devices based at least in part on the one or more object access properties of the object to be received. In response to determining the type of storage device, the storage engine may allocate a storage device of such type for the object. The storage engine may then receive the object, and store the object into the allocated storage device.

Abstract: The present invention is directed to arylpyrrolopyridine derivatives of Formula A: The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease or cancer.

Abstract: The present invention is directed to arylpyrrolopyridine derivatives of Formula A: The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease or cancer.

Abstract: The present invention is directed to arylpyrrolopyridine derivatives of formula (A) (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease cancer.

Abstract: The present invention is directed to arylpyrrolopyridine derivatives of formula (A) (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease cancer.

Abstract: The present invention is directed to arylpyrrolopyridine derivatives of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease or cancer.

Abstract: The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Va); and (ii) converting said compound of formula (Va) to a compound of formula (Ia) or (Ic); or (B) (i) treating a compound of formula (IVb), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Vb); and (ii) converting said compound of formula (Vb) to a compound of formula (Ib) or (Id).

Abstract: The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R48 is alkyl or tosyl, with an oxidising agent to form a compound of formula (Va); and (ii) converting said compound of formula (Va) to a compound of formula (Ia) or (Ic); or (B) (i) treating a compound of formula (IVb), where R48 is alkyl or tosyl, with an oxidising agent to form a compound of formula (Vb); and (ii) converting said compound of formula (Vb) to a compound of formula (Ib) or (Id).

Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease and diseases involving matrix or cartilate degradation.

Abstract: The present invention relates to a process for preparing a compound of formula I, wherein R1 is Pg1 or P1?; P1? is CO-hydrocarbyl; P2 is CH2, O or N-Pg2; and Pg1 and Pg2 are each independently nitrogen protecting groups; (i) reacting a compound of formula II with a dioxirane to form an epoxide of formula III; where X is selected from CN, CH2N3, CH2NH-Pg2, ONH-Pg2, NHNH-Pg2, N(Pg2)NH-Pg2; (ii) converting a compound of formula III to a compound of formula I