Abstract: Disclosed is a zinc zoledronate micro-nanoparticle adjuvant, which contains zinc and zoledronic acid and optionally contains a phosphate and aluminum. The preparation method therefor comprises performing mixed precipitation on a soluble salt solution containing zinc ions, zoledronic acid, and sodium hydroxide. The adjuvant can be used to prepare vaccines, etc.

Abstract: The present invention pertains to the field of pharmaceutical technology. Specifically, the present invention relates to a zinc risedronate micro/nano adjuvant with sustained-release function formed by mineralization of zinc ions and risedronic acid as main components and its use as a vaccine adjuvant. The present invention also relates to a method for preparing zinc risedronate micro/nano adjuvant. The present invention also relates to a chemical composition, vaccine adjuvant and vaccine composition comprising zinc risedronate micro/nano adjuvant. The present invention also relates to a use of zinc risedronate micro/nano adjuvant as a vaccine adjuvant.

Abstract: A walking path database stores data describing a set of connected walking paths. The walking path database may be generated based on an existing map database describing connected roads. The walking path database and map database are used to generate a combined walking and driving route, where a user walks to a particular pickup location, and a vehicle drives the user from the pickup location to a particular destination. The combined walking and driving route may be a route that minimizes the overall trip time.

Abstract: Vehicles detect temporary traffic restrictions and provide information describing the traffic restrictions to a remote computer system. The remote computer system can determine a routing cost for the traffic restriction and alert other vehicles in a fleet of vehicles about the traffic restrictions. The other vehicles can account for the routing cost when determining a route to follow; the route may avoid the traffic restriction. Vehicles in the fleet, when driving near a particular traffic restriction, may perceive the area where the traffic restriction was detected and provide updates about the traffic restriction, e.g., whether the boundaries of the TTR have changed (e.g., a construction area or emergency response has expanded or moved), or the TTR has been removed (e.g., a construction area has reopened, or a stopped vehicle has left the roadway).

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: The present invention pertains to the field of pharmaceutical technology. Specifically, the present invention relates to a zinc risedronate micro/nano adjuvant with sustained-release function formed by mineralization of zinc ions and risedronic acid as main components and its use as a vaccine adjuvant. The present invention also relates to a method for preparing zinc risedronate micro/nano adjuvant. The present invention also relates to a chemical composition, vaccine adjuvant and vaccine composition comprising zinc risedronate micro/nano adjuvant. The present invention also relates to a use of zinc risedronate micro/nano adjuvant as a vaccine adjuvant.

Abstract: Disclosed is a zinc zoledronate micro-nanoparticle adjuvant, which contains zinc and zoledronic acid and optionally contains a phosphate and aluminum. The preparation method therefor comprises performing mixed precipitation on a soluble salt solution containing zinc ions, zoledronic acid, and sodium hydroxide. The adjuvant can be used to prepare vaccines, etc.

Abstract: Provided is a resistor structure of a series resistor of an Electro-Static Discharge (ESD) device. A poly resistor is divided into N small parts, and each small part is connected to an upper-part metal layer through a respectively corresponding Contact and Via. The Contact and Via corresponding to each small part and the connected upper-part metal layer form an independent unit. A metal aluminum material is adopted for the Via and the upper-part metal layer. The metal aluminum material or an aluminum alloy material is adopted for the Contact. A heat capacity characteristic of metal aluminum is utilized, and an existing structure is ingeniously utilized, so that the resistor may be prevented from being damaged by heating caused by the same ESD current, and meanwhile, an overall size of a circuit where the ESD device is located is greatly reduced.

Abstract: Provided is a low-power-consumption Constant-On-Time (COT) timing circuit design method and a timing circuit. A Resistor-Capacitor (RC) circuit is adopted for timing, to eliminate static power consumption of a timer. A specific structure includes a fourth P-channel Metal Oxide Semiconductor (MOS) transistor M4 of which a source is connected to an input voltage VIN, a gate is connected to a COT control terminal TON_CONTROL and a drain is connected with one end of a fourth resistor R4. The other end of the fourth resistor R4 is connected with one end of a fourth capacitor C4. The other end of the fourth capacitor C4 is grounded. A negative input of a comparator VCMP is connected with a reference voltage, and a positive input is connected between the fourth capacitor C4 and the fourth resistor R4.

Abstract: Provided is a low-power-consumption Constant-On-Time (COT) timing circuit design method and a timing circuit. A Resistor-Capacitor (RC) circuit is adopted for timing, to eliminate static power consumption of a timer. A specific structure includes a fourth P-channel Metal Oxide Semiconductor (MOS) transistor M4 of which a source is connected to an input voltage VIN, a gate is connected to a COT control terminal TON_CONTROL and a drain is connected with one end of a fourth resistor R4. The other end of the fourth resistor R4 is connected with one end of a fourth capacitor C4. The other end of the fourth capacitor C4 is grounded. A negative input of a comparator VCMP is connected with a reference voltage, and a positive input is connected between the fourth capacitor C4 and the fourth resistor R4.

Abstract: An isolated power supply circuit has a first reference ground, a second reference ground, a power source, a first receiving circuit, a second receiving circuit, a first inverter circuit, a second inverter circuit and an isolated conversion circuit. The first reference ground and the second reference ground are isolated from each other. The first receiving circuit is coupled to the first reference ground. The second receiving circuit is coupled to the second reference ground. The power source provides a first power signal for the first receiving circuit directly. The first inverter circuit and the second inverter circuit receive the first power signal and produce a first inverter signal and a second inverter signal. And the isolated conversion circuit outputs a second power signal to the second receiving circuit based on the first inverter signal and the second inverter signal.

Abstract: A method for controlling a multi-channel SMPS having N switching circuits. The method is generating a fast system clock and N load indication signals indicative of load statuses of the N switching circuits, then generating N clock control signals based on the preset pulses of the fast system clock and the N load indication signals. If one of the N switching circuits is detected to transit from a heavy load condition to a light load condition, forming the corresponding clock control signal based on the first pulse of the fast system clock after the corresponding load indication signal transits from the first state to the second state.

Abstract: Provided is a resistor structure of a series resistor of an Electro-Static Discharge (ESD) device. A poly resistor is divided into N small parts, and each small part is connected to an upper-part metal layer through a respectively corresponding Contact and Via. The Contact and Via corresponding to each small part and the connected upper-part metal layer form an independent unit. A metal aluminum material is adopted for the Via and the upper-part metal layer. The metal aluminum material or an aluminum alloy material is adopted for the Contact. A heat capacity characteristic of metal aluminum is utilized, and an existing structure is ingeniously utilized, so that the resistor may be prevented from being damaged by heating caused by the same ESD current, and meanwhile, an overall size of a circuit where the ESD device is located is greatly reduced.

Abstract: An isolated power supply circuit has a first reference ground, a second reference ground, a power source, a first receiving circuit, a second receiving circuit, a first inverter circuit, a second inverter circuit and an isolated conversion circuit. The first reference ground and the second reference ground are isolated from each other. The first receiving circuit is coupled to the first reference ground. The second receiving circuit is coupled to the second reference ground. The power source provides a first power signal for the first receiving circuit directly. The first inverter circuit and the second inverter circuit receive the first power signal and produce a first inverter signal and a second inverter signal. And the isolated conversion circuit outputs a second power signal to the second receiving circuit based on the first inverter signal and the second inverter signal.

Abstract: A boost converter having an inductor having a first terminal coupled to an input port to receive the input voltage; a high side switch coupled between the inductor and an output port; a low side switch coupled between the inductor and a ground reference; and a control circuit configured to receive a feedback signal indicative of the output voltage and a reference signal, and to provide a high side control signal and a low side control signal based on the feedback signal and the reference signal; wherein the low side switch on time period is controlled to be constant by the low side control signal when the input voltage and the output voltage are fixed.

Abstract: A power converter with average current detection and the corresponding detecting method and detecting circuit are disclosed. The average current detecting circuit has an average voltage detecting circuit and a voltage-current converting circuit. The average voltage detecting circuit generates a voltage across a detecting resistor by letting an inductor current flowing through an output inductor of the power converter flowing through the detecting resistor. Further, the average voltage detecting circuit samples the voltage across the detecting resistor when a switch of the power converter transits from an on state into an off state and the opposite and then calculates the average value of the two sampled voltages. The voltage-current converting circuit converts the average value into an average current by multiplying the average value by a scaling factor.

Abstract: A control circuit for a switching power converter is disclosed. The control circuit may comprise an OFF control signal generation module configured to generate an OFF control signal having an inactive logic state and an active logic state. The control circuit is configured to turn OFF a main switch of the switching power converter in response to the active logic state. The OFF control signal generation module can regulate an ON time of the main switch through regulating a change of the OFF control signal from the inactive logic state to the active logic state based on a first capacitor voltage across a first capacitor to maintain a switching frequency of the main switch substantially constant. The first capacitor is charged in a predetermined time since the main switch is turned ON and discharged after the predetermined time.

Abstract: A method for controlling a multi-channel SMPS having N switching circuits. The method is generating a fast system clock and N load indication signals indicative of load statuses of the N switching circuits, then generating N clock control signals based on the preset pulses of the fast system clock and the N load indication signals. If one of the N switching circuits is detected to transit from a heavy load condition to a light load condition, forming the corresponding clock control signal based on the first pulse of the fast system clock after the corresponding load indication signal transits from the first state to the second state.

Abstract: A bootstrap circuit integrated to a voltage converter integrated circuit (IC) and a voltage converter IC for a switch mode voltage regulator. The bootstrap circuit is used to provide a bootstrap voltage signal for driving a high side switch of the voltage converter IC. The bootstrap circuit has a pre-charger and a bootstrap capacitor. The pre-charger provides a first bootstrap signal to pre-charge a control terminal of the high side switch, and the bootstrap capacitor provides a second bootstrap signal to enhance the charge of the control terminal of the high side switch.