Abstract: The present invention provides a toxin molecule suitable for an antibody drug conjugate. In particular, the present invention provides a compound represented by formula (I) below or a pharmaceutically acceptable salt or hydrate thereof. The compound of the present invention can be used in the preparation of a pharmaceutical composition for treating diseases associated with tumor cell proliferation.

Abstract: An artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring a search record set within a preset time period; matching the search record set with an encyclopedia entry set, and selecting a first set of points of interest from the encyclopedia entry set according to a match result; matching the search record set with a microblog topic set, and selecting a second set of points of interest from the microblog topic set according to a match result; and adding the first set of points of interest and the second set of points of interest to a set of points of interest. This embodiment achieves an accurate acquisition of the points of interest, thus facilitating the implementation of a targeted information push.

Abstract: The present invention provides a JAK kinase inhibitor and a preparation and application thereof, and the present invention specifically provides a compound having a structure represented in the following formula I, an enantiomer thereof, or a pharmaceutically acceptable salt thereof. The compound has uniquely advantageous JAK kinase inhibitory activity, and as such may be used for treatment of a disease or illness related to JAK kinase activity or expression level.

Abstract: An artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring search click information recorded within a predetermined time period; generating a candidate entry set by selecting, from the search click information, entries having click volumes exceeding a click volume threshold within a preset unit time period; forming, for each candidate entry in the candidate entry set, a click volume sequence according to a chronological order of each of the click volumes corresponding to the candidate entry in the predetermined time period; determining, based on click volume sequences, categories of the candidate entries respectively corresponding to click volume sequences; and determining candidate entries having the categories being a preset category as points of interest to generate a set of points of interest.

Abstract: The present invention relates to methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: The invention relates to solid forms of certain N-(pyrimidinyloxy)acrylamide derivatives that are useful in the treatment of proliferation and immunological disorders and other diseases related to the dysregulation of kinases including EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK. The invention provides methods of making these materials and their salts and polymorphs, and intermediates for preparing these materials, as well as pharmaceutical compositions comprising these materials. The solid forms and pharmaceutical compositions comprising them are useful to treat conditions including a proliferation disorder, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye, rheumatoid arthritis, or lupus.

Abstract: Disclosed methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC AND TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: A method and apparatus for pushing information. A specific implementation of the method includes: parsing page content browsed by a user to extract a keyword of the page content and determine a theme corresponding to the keyword; determining a preset keyword matching the keyword in a preset keyword collection; determining an associated keyword associated with the determined preset keyword based on a pre-established associated relationship of the preset keyword; and pushing information corresponding to the theme and/or the associated keyword to the user. This implementation implements targeted information push.

Abstract: Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Abstract: The present disclosure discloses an artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring a search record set within a preset time period; matching the search record set with an encyclopedia entry set, and selecting a first set of points of interest from the encyclopedia entry set according to a match result; matching the search record set with a microblog topic set, and selecting a second set of points of interest from the microblog topic set according to a match result; and adding the first set of points of interest and the second set of points of interest to a set of points of interest. This embodiment achieves an accurate acquisition of the points of interest, thus facilitating the implementation of a targeted information push.

Abstract: A method and apparatus for pushing information. A specific implementation of the method includes: parsing page content browsed by a user to extract a keyword of the page content and determine a theme corresponding to the keyword; determining a preset keyword matching the keyword in a preset keyword collection; determining an associated keyword associated with the determined preset keyword based on a pre-established associated relationship of the preset keyword; and pushing information corresponding to the theme and/or the associated keyword to the user. This implementation implements targeted information push.

Abstract: The present disclosure discloses an artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring search click information recorded within a predetermined time period; generating a candidate entry set by selecting, from the search click information, entries having click volumes exceeding a click volume threshold within a preset unit time period; forming, for each candidate entry in the candidate entry set, a click volume sequence according to a chronological order of each of the click volumes corresponding to the candidate entry in the predetermined time period; determining, based on click volume sequences, categories of the candidate entries respectively corresponding to click volume sequences; and determining candidate entries having the categories being a preset category as points of interest to generate a set of points of interest.

Abstract: Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.