Abstract: The invention relates to solid forms of certain N-(pyrimidinyloxy)acrylamide derivatives that are useful in the treatment of proliferation and immunological disorders and other diseases related to the dysregulation of kinases including EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK. The invention provides methods of making these materials and their salts and polymorphs, and intermediates for preparing these materials, as well as pharmaceutical compositions comprising these materials. The solid forms and pharmaceutical compositions comprising them are useful to treat conditions including a proliferation disorder, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye, rheumatoid arthritis, or lupus.

Abstract: Embodiments of the disclosure provide an image processing method and apparatus, an electronic device and a storage medium. The method includes: when it is detected that a main body to be processed on a display interface is a target main body, adding an augmented reality (AR) special effect model for the target main body; according to a current video frame and a previous historical video frame, determining a target display location of the AR special effect model in the current video frame; displaying the AR special effect model at the target display position to obtain a target special effect video frame corresponding to the current video frame.

Abstract: Embodiments of the present disclosure provide a method and apparatus for determining effect video, an electronic device, and a storage medium. The method includes: in response to detecting that a target effect template is triggered, retrieving a target configuration file; determining the target edit item corresponding to the target effect template and the edit parameter of the target edit item by parsing the target configuration file, and displaying the target edit item; in response to receiving an effect material to be edited corresponding to a target edit item, displaying an edit parameter, so as to determine a target effect material corresponding to the effect material to be edited based on an adjustment operation on the edit parameter; and based on the target effect material and a video stream to be processed, generating a target effect video with the video stream to be processed as background information.

Abstract: Provided in the present disclosure are a video generation method, apparatus and device, and a storage medium. The method includes: when a trigger operation for a preset effect entry has been received, displaying, on a photographic page, a preset effect resource for a target POI which corresponds to a first user, wherein the preset effect resource comprises at least one first virtual object, and each first virtual object is displayed on the photographic page in a manner of moving towards the target POI; generating a second virtual object on the basis of a virtual object generation control on the photographic page; when a trigger operation for the second virtual object has been received, displaying the second virtual object on the photographic page in a manner of moving towards the target POI; and then generating a resulting video on the basis of the photographic page.

Abstract: The present disclosure relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods comprising a compound of any one of Formulas (I), (II), (III), and (IV) as further described herein. The compounds are inhibitors of protein kinases associated with cancers, and are thus useful for the treatment and/or prevention of a tumor or cancer.

Abstract: Provided in the present disclosure are a video generation method and apparatus, and a device and a storage medium. The method includes: firstly, when an application request for a target effect object has been received, acquiring location information of the current user; then, on the basis of the location information of the current user, determining a target place of interest (POI) corresponding to the current user; acquiring an effect resource of the target POI, and on the basis of the location information of the current user and location information of the target POI, determining a direction relationship between the current user and the target POI; on the basis of the direction relationship, displaying, on a photographic page, a photographic effect corresponding to the effect resource; and then on the basis of the photographic effect corresponding to the effect resource, generating a result video corresponding to the target effect object.

Abstract: A foldable apparatus is provided. The foldable apparatus includes a first foldable part, a middle bending part, and a second foldable part that are connected in sequence. The first foldable part and the second foldable part can rotate relative to each other based on the middle bending part. A first wireless communication chip is disposed in the first foldable part. A second wireless communication chip is disposed in the second foldable part. In the foldable apparatus, wireless communication is used to replace conventional physical wiring for internal signal transmission. The loss of a communication carrier is reduced through wireless communication. This ensures that stable transmission performance between the first foldable part and the second foldable part.

Abstract: A method includes obtaining an average radio frequency exposure value over a target time window, where the target time window is a standard time window, determining a power threshold corresponding to the average radio frequency exposure value, where the power threshold is a preset power value corresponding to a preset value range to which the average radio frequency exposure value belongs, and controlling a transmit power of the wireless device based on the power threshold over a controlled time window.

Abstract: In various examples, low power proximity based threat detection using optical flow for vehicle systems and applications are provided. Some embodiments may use a tiered framework that uses sensor fusion techniques to detect and track the movement of a threat candidate, and perform a threat classification and/or intent prediction as the threat candidate approaches approach. Relative depth indications from optical flow, computed using data from image sensors, can be used to initially segment and track a moving object over a sequence of image frames. Additional sensors and processing may be brought online when a moving object becomes close enough to be considered a higher risk threat candidate. A threat response system may generate a risk score based on a predicted intent of a threat candidate, and when the risk score exceeds a certain threshold, then the threat response system may respond accordingly based on the threat classification and/or risk score.

Abstract: The present application relates to an anti-tumor compound and use thereof, specifically, the present application relates to a ligand conjugate or a tautomer, a mesomer, a racemate, an enantiomer and a diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. The present application further relates to a method for preparing the ligand conjugate and the use thereof.

Abstract: The present invention provides a toxin molecule suitable for an antibody drug conjugate. In particular, the present invention provides a compound represented by formula (I) below or a pharmaceutically acceptable salt or hydrate thereof. The compound of the present invention can be used in the preparation of a pharmaceutical composition for treating diseases associated with tumor cell proliferation.

Abstract: A fast disintegrating thermally gelling hydroxypropyl methylcellulose (Hypromellose, HPMC) empty capsule can be formed from HPMC 2910 that has a methoxyl content of 27.0% to 30.0% (w/w) and a hydroxylpropoxyl content of 7.0% to 12.0% (w/w). Except for adding a small amount of opacifier and/or colorant, according to customer requirements, the composition can be free of any plasticizer, moisturizing agent, stabilizer, coagulant and other auxiliary materials. The resulting capsule dipped by thermal gelation method has no cracks or wrinkles. The resulting capsule exhibits rapid disintegration release, independent of any dissolution medium, that is significantly faster than capsules dipped by thermal gelation using Hypromellose 2906.

Abstract: Methods and systems are directed to a content services platform. The content services platform may include a processor and a memory storing instructions that, when executed by the processor, configure the content services platform to perform a method. The method may include receiving a request to initiate a shared session from a first client, the request including a first client identifier. Based on the received request, a session identifier may be provided to the first client associated with the first client identifier. A request from a second client may be received and may be associated with the session identifier. Thus, when message data from the first client is received, the message data may be added to a queue associated with the session identifier such that the message data may be provided from the queue to the second client based on the session identifier.

Abstract: Media, methods, and systems are disclosed for optimizing performance of a running application in connection with a group-based communication system. Log data is collected regarding prior metrics for applications that have encountered performance events. Application state information is monitored and a machine-learning model mapping application metrics to performance outcomes predicts whether the running application will encounter a performance event. The machine-learning model mapping application metrics to performance outcomes is trained based on the collected logs. Based on whether a degradation outcome will be impactful, an application performance parameter may be degraded.

Abstract: An artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring a search record set within a preset time period; matching the search record set with an encyclopedia entry set, and selecting a first set of points of interest from the encyclopedia entry set according to a match result; matching the search record set with a microblog topic set, and selecting a second set of points of interest from the microblog topic set according to a match result; and adding the first set of points of interest and the second set of points of interest to a set of points of interest. This embodiment achieves an accurate acquisition of the points of interest, thus facilitating the implementation of a targeted information push.

Abstract: The present invention provides a JAK kinase inhibitor and a preparation and application thereof, and the present invention specifically provides a compound having a structure represented in the following formula I, an enantiomer thereof, or a pharmaceutically acceptable salt thereof. The compound has uniquely advantageous JAK kinase inhibitory activity, and as such may be used for treatment of a disease or illness related to JAK kinase activity or expression level.

Abstract: Methods and systems are directed to a content services platform. The content services platform may include a processor and a memory storing instructions that, when executed by the processor, configure the content services platform to perform a method. The method may include receiving a request to initiate a shared session from a first client, the request including a first client identifier. Based on the received request, a session identifier may be provided to the first client associated with the first client identifier. A request from a second client may be received and may be associated with the session identifier. Thus, when message data from the first client is received, the message data may be added to a queue associated with the session identifier such that the message data may be provided from the queue to the second client based on the session identifier.

Abstract: A foldable apparatus is provided. The foldable apparatus includes a first foldable part, a middle bending part, and a second foldable part that are connected in sequence. The first foldable part and the second foldable part can rotate relative to each other based on the middle bending part. A first wireless communication chip is disposed in the first foldable part. A second wireless communication chip is disposed in the second foldable part. In the foldable apparatus, wireless communication is used to replace conventional physical wiring for internal signal transmission. The loss of a communication carrier is reduced through wireless communication. This ensures that stable transmission performance between the first foldable part and the second foldable part.

Abstract: An artificial intelligence based method and apparatus for processing information. A specific embodiment of the method includes: acquiring search click information recorded within a predetermined time period; generating a candidate entry set by selecting, from the search click information, entries having click volumes exceeding a click volume threshold within a preset unit time period; forming, for each candidate entry in the candidate entry set, a click volume sequence according to a chronological order of each of the click volumes corresponding to the candidate entry in the predetermined time period; determining, based on click volume sequences, categories of the candidate entries respectively corresponding to click volume sequences; and determining candidate entries having the categories being a preset category as points of interest to generate a set of points of interest.

Abstract: Systems and methods for generating a video including a plurality of graphic objects provided in a shared environment is described. The method includes acquiring, at a first computing device, a shared session identifier from a shared session manager, the shared session identifier being associated with a first user identifier, receiving a selection of a second user identifier, causing the shared session identifier and the first user identifier to be provided to a second computing device associated with the second user identifier, receiving as input, a first graphic object for rendering to a display associated with the first computing device, the first graphic object being associated with the first user identifier, receiving from a data synchronizer, a second graphic object associated with the second user identifier and the shared session identifier for rendering to the display associated with the second computing device, and generating a video including graphic objects.