Patents by Inventor Yili Qian

Yili Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A TUNABLE PHOSPHORYLATION-BASED FEEDBACK CONTROLLER OF MAMMALIAN GENE EXPRESSION
    Publication number: 20240018528
    Abstract: Provided herein are feedback controller circuits and cell state classifiers for tunable phosphorylation-based transcriptional regulation of gene expression in cells based on intracellular miRNA profiles and degradation by small molecules. Also provided are methods of using feedback controller circuits and cell state classifiers for determining the cell state, and methods of treating cells and subjects using feedback controller circuits and cell state classifiers encoding therapeutic output molecules.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 18, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Ross D. Jones, Yili Qian, Domitilla Del Vecchio, Ron Weiss
  • ENGINEERED INCOHERENT FEED FORWARD LOOP AND USES THEREOF
    Publication number: 20230159948
    Abstract: The present disclosure, at least in part, relates to an engineered incoherent feed forward loop (iFFL) comprising a first transcription unit encoding an endoribonuclease and a second transcription unit encoding an output molecule and an endoribonuclease target site located in the 5? UTR of the output molecule coding sequence. The engineered iFFL, at least in part, can be used for sustained expression of an output molecule despite of transcription resource disturbance in a given environment.
    Type: Application
    Filed: January 20, 2021
    Publication date: May 25, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Ross D. Jones, Breanna E. DiAndreth, Domitilla Del Vecchio, Yili Qian
  • ENGINEERED INCOHERENT FEED FORWARD LOOP AND USES THEREOF
    Publication number: 20210292784
    Abstract: The present disclosure, at least in part, relates to an engineered incoherent feed forward loop (iFFL) comprising a first transcription unit encoding an endoribonuclease and a second transcription unit encoding an output molecule and an endoribonuclease target site located in the 5? UTR of the output molecule coding sequence. The engineered iFFL, at least in part, can be used for sustained expression of an output molecule despite of transcription resource disturbance in a given environment.
    Type: Application
    Filed: January 20, 2021
    Publication date: September 23, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Ross D. Jones, Breanna E. DiAndreth, Domitilla Del Vecchio, Yili Qian