Abstract: This disclosure is directed to a pharmaceutical composition comprising sodium bicarbonate and a polymer-drug nanoaggregate having a polymer and a taxane. The polymer is water soluble and comprises at least one first terminal group modified with a hydrophobic moiety and a second terminal group modified with a hydrophilic moiety and can be a modified symmetrically or asymmetrically branched polymers. The taxane can include paclitaxel, docetaxel, cabazitaxel, larotaxel, milataxel, ortataxel, tesetaxel, derivatives therefrom or a combination thereof, which are water insoluble or poorly water soluble. Such polymer-drug nanoaggregates can improve drug solubility, stability, in vivo availability and efficacy, and reduce side effects such as renal toxicity. This invention is also directed to a process for producing the pharmaceutical composition comprising the polymer-drug nanoaggregate.

Abstract: Provided herein are a series of compounds and their use as an adjuvant. Provided herein are the compounds, a composition comprising the compounds, and the use thereof. These compounds can be used as an adjuvant for a vaccine, and compared to the conventional aluminum adjuvant, the compounds can significantly improve the cellular and humoral immune responses to a vaccine. The compounds as an adjuvant can increase a broad-spectrum protection against various corona viruses such as SARS virus, influenza viruses, and HIV viruses, and significantly enhance persistence of immunoprotection of vaccines.

Abstract: A computer-implemented method, a computer system, and a computer program product are provided for estimating output data that includes or is based on a number of containers, which may or may not be in receptacles. The method involves using an object detection algorithm operating on an input digital image to detect container images and receptacle images (if any), and using an estimation algorithm operating on the detected images to estimate the number of containers. Estimating the number of containers may involve counting the number of containers within different container classes, as determined by the object detection algorithm. Estimating the number of containers may involve estimating a size of a receptacle in a detected receptacle image based on analysis of a detected reference container image. A detected reference object image may be used to assist with classifying detected container images in different container classes.

Abstract: A computer-implemented method, a computer system, and a computer program product are provided for estimating output data that includes or is based on a number of containers, which may or may not be in receptacles. The method involves using an object detection algorithm operating on an input digital image to detect container images and receptacle images (if any), and using an estimation algorithm operating on the detected images to estimate the number of containers. Estimating the number of containers may involve counting the number of containers within different container classes, as determined by the object detection algorithm. Estimating the number of containers may involve estimating a size of a receptacle in a detected receptacle image based on analysis of a detected reference container image. A detected reference object image may be used to assist with classifying detected container images in different container classes.

Abstract: A communication system onboard an aircraft includes: a first multi-frequency transceiver coupled to a first antenna; a second multi-frequency transceiver coupled to a second antenna; and at least one processor communicatively coupled to a memory, the first multi-frequency transceiver, and the second multi-frequency transceiver. The at least one processor is configured to: establish a first air-to-ground data communication link with the first multi-frequency transceiver and a first ground station using a first frequency; determine that a handoff from the first frequency to a second frequency is needed, wherein the second frequency is different from the first frequency; and establish a second air-to-ground data communication link with the second multi-frequency transceiver and a second ground station using a second frequency, wherein the first air-to-ground data communication link is maintained until the second air-to-ground data communication link is successfully established.

Abstract: In some examples, a system includes a receiver configured to receive a signal and processing circuitry configured to determine a velocity vector of the ownship vehicle and determine a position of a target vehicle relative to the ownship vehicle based on the signal, determine a velocity vector of the target vehicle relative to the ownship vehicle based on the signal and the velocity vector of the ownship vehicle, and determine a characteristic of a graphical vector icon of the velocity vector of the target vehicle based on a display range of a graphical user interface. The processing circuitry is also configured to present, via a display, the graphical user interface including a first graphical icon corresponding to the ownship vehicle, a second graphical icon corresponding to the target vehicle based on the position of the target vehicle relative to the ownship vehicle, and the graphical vector icon with the characteristic.

Abstract: A computer-implemented method, a computer system, and a computer program product are provided for estimating output data that includes or is based on a number of containers, which may or may not be in receptacles. The method involves using an object detection algorithm operating on an input digital image to detect container images and receptacle images (if any), and using an estimation algorithm operating on the detected images to estimate the number of containers. Estimating the number of containers may involve counting the number of containers within different container classes, as determined by the object detection algorithm. Estimating the number of containers may involve estimating a size of a receptacle in a detected receptacle image based on analysis of a detected reference container image. A detected reference object image may be used to assist with classifying detected container images in different container classes.

Abstract: A communication system onboard an aircraft includes: a first multi-frequency transceiver coupled to a first antenna; a second multi-frequency transceiver coupled to a second antenna; and at least one processor communicatively coupled to a memory, the first multi-frequency transceiver, and the second multi-frequency transceiver. The at least one processor is configured to: establish a first air-to-ground data communication link with the first multi-frequency transceiver and a first ground station using a first frequency; determine that a handoff from the first frequency to a second frequency is needed, wherein the second frequency is different from the first frequency; and establish a second air-to-ground data communication link with the second multi-frequency transceiver and a second ground station using a second frequency, wherein the first air-to-ground data communication link is maintained until the second air-to-ground data communication link is successfully established.

Abstract: A method of inter-RPR-ring bridge redundancy configures a priority for each inter-ring bridge; constitutes a redundancy group by more than one inter-ring bridges on both two RPR rings, and configures one inter-ring bridge as a primary inter-ring bridge in the redundancy group which is in charge of forwarding packets, while the other(s) is (are) set to be secondary inter-ring bridge(s). When the redundancy group changes, an inter-ring bridge with the highest priority and having an inter-ring communication ability is elected to be the primary inter-ring bridge. According to the method provided by the present invention, an RPR ring can recover rapidly after the RPR bridge changes. As a result, the services on the RPR ring are ensured to be used normally, the network communication delay is reduced, and the burden of the network communication is reduced.