Abstract: The present disclosure provides a camera optical lens including from an object side to an image side: a first lens having a negative refractive power; a second lens having a positive refractive power; a third lens having a positive power; a fourth lens having a negative refractive power, a fifth lens having a positive power; and a sixth lens having a negative refractive power; wherein the camera optical lens satisfies following conditions: 60.00?v1?90.00; 60.00?v3?90.00; 1.00?d10/d11?5.00; where v1 denotes an abbe number of the first lens, v3 denotes an abbe number of the third lens, d10 denotes an on-axis distance from the image-side surface of the fifth lens to the object-side surface of the sixth lens, and d11 denotes an on-axis thickness of the sixth lens. The camera optical lens in the present disclosure satisfies a design requirement of ultra wide angle and ultra-thinness while having good optical performance.

Abstract: The present disclosure provides a camera optical lens including from an object side to an image side: a first lens having a negative refractive power; a second lens having a positive refractive power; a third lens having a positive power; a fourth lens having a negative refractive power, a fifth lens having a positive power; and a sixth lens having a negative refractive power; wherein the camera optical lens satisfies following conditions: 60.00?v1?90.00; 60.00?v3?90.00; 1.00?d10/d11?5.00; where v1 denotes an abbe number of the first lens, v3 denotes an abbe number of the third lens, d10 denotes an on-axis distance from the image-side surface of the fifth lens to the object-side surface of the sixth lens, and d11 denotes an on-axis thickness of the sixth lens. The camera optical lens in the present disclosure satisfies a design requirement of ultra wide angle and ultra-thinness while having good optical performance.

Abstract: The present disclosure provides a camera optical lens with six lenses including from an object side to an image side: a first lens having a negative refractive power; a second lens having a positive refractive power; a third lens having a positive power; a fourth lens having a negative refractive power, a fifth lens having a positive power; and a sixth lens having a negative refractive power; wherein the camera optical lens satisfies following conditions: 3.00?f2/f?5.00; ?10.00?(R9+R10)/(R9?R10)??2.00; where f denotes a focal length of the camera optical lens, f2 denotes a focal length of the second lens, R9 denotes a central curvature radius of an object-side surface of the fifth lens, and R10 denotes a central curvature radius of an image-side surface of the fifth lens. The camera optical lens in the present disclosure satisfies a design requirement of wide angle and ultra-thinness while having good optical performance.

Abstract: Provided are methods for calculating codon pair translational kinetics values, creating a synthetic gene for expression in a host organism, and providing codon pair translational kinetic values. The methods typically are directed to refinement of statistical observed versus expected codon pair frequencies using one of several factors such as amino acid sequence homology, secondary or tertiary structural considerations, and empirical measurements. In some synthetic genes codon pairs are predicted not to cause a translational pause in the host organism, thereby providing a polynucleotide sequence encoding the desired polypeptide with desired translational kinetics properties. The methods can be performed using multiple parameter nucleotide sequence optimization methods, such as branch-and-bound methods for nucleotide sequence refinement.