Patents by Inventor Yimin Dong

Yimin Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
    Publication number: 20240076281
    Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, inhibitors of apoptosis proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
    Type: Application
    Filed: November 28, 2022
    Publication date: March 7, 2024
    Applicant: Arvinas Operations, Inc.
    Inventors: Yimin QIAN, Hanqing DONG, Jing WANG
  • Flexible substrate and manufacture method thereof, and flexible organic light-emitting diode display substrate
    Patent number: 10930869
    Abstract: A flexible substrate and a manufacture method thereof, and a flexible organic light-emitting diode display substrate. The flexible substrate comprises a first flexible layer and a second flexible layer stacked with each other and a hydrophobic layer on at least one side of at least one of the first flexible layer and the second flexible layer.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: February 23, 2021
    Assignees: CHENGDU BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Zhongfei Dong, Yan Hu, Hongguang Yuan, Yue Wei, Jianxiong Huang, Guodong Liu, Yimin Dong, Yuan Chen
  • Flexible Substrate and Manufacture Method Thereof, and Flexible Organic Light-Emitting Diode Display Substrate
    Publication number: 20200067001
    Abstract: A flexible substrate and a manufacture method thereof, and a flexible organic light-emitting diode display substrate. The flexible substrate comprises a first flexible layer and a second flexible layer stacked with each other and a hydrophobic layer on at least one side of at least one of the first flexible layer and the second flexible layer.
    Type: Application
    Filed: April 26, 2019
    Publication date: February 27, 2020
    Inventors: Zhongfei DONG, Yan HU, Hongguang YUAN, Yue WEI, Jianxiong HUANG, Guodong LIU, Yimin DONG, Yuan CHEN
  • Polynucleotide, vector, host cell and method for producing human hepatoma-derived growth factor 5 polypeptide
    Patent number: 7361486
    Abstract: The invention provides a cDNA sequence of human hepatoma derived growth factor 5 (HDGF5). The present invention also relates to the polypeptides encoded by the nucleotide sequences, the uses of these polynucleotides and polypeptides, and the methods for producing HDGF5 polynucleotides and polypeptides.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: April 22, 2008
    Inventors: Long Yu, Lisha Tang, Zekun Guo, Pingzhao Zhang, Yimin Dong
  • Human hepatoma-derived growth factor 5, its encoding sequence, method for producing it and the uses of it
    Publication number: 20050080241
    Abstract: The invention provides a cDNA sequence of human hepatoma derived growth factor 5 (HDGF5). The present invention also relates to the polypeptides encoded by the nucleotide sequences, the uses of these polynucleotides and polypeptides, and the methods for producing HDGF5 polynucleotides and polypeptides.
    Type: Application
    Filed: January 2, 2003
    Publication date: April 14, 2005
    Inventors: Long Yu, Lisha Tang, Zekun Guo, Pingzhao Zhang, Yimin Dong