Abstract: Methods and systems for estimating converted-wave statics are disclosed. The methods include obtaining a multicomponent seismic dataset for a subterranean region, determining an array of PP-source statics and an array of PP-receiver statics for the PP-seismic dataset, generating a PP-receiver stack based on the PP-seismic dataset, the array of PP-source statics, and the array of PP-receiver statics, and generating a PS-receiver stack based on the PS-seismic dataset and the array of PP-source statics. The methods also include identifying a PP-target event on the PP-receiver stack, forming a space-time window of the PS-receiver stack guided by the PP-target event, determining an objective function, and determining an array of PS-receiver statics based on an extremum of the objective function.

Abstract: The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.

Abstract: The present disclosure relates to a device and a system for testing flatness. The device for testing flatness includes a base, a testing platform, and a ranging sensor. The testing platform is assembled on the base. The testing platform includes a supporting structure. The supporting structure is disposed on the side of the testing platform away from the base and is used to support a to-be-tested board. The structure matches the structure of the to-be-tested board. The ranging sensor is disposed on the side of the testing platform away from the base. After the to-be-tested board is placed on the testing platform, the ranging sensor is used to test distances between a number N of to-be-tested positions on the to-be-tested board and the ranging sensor, to obtain N pieces of distance information, and the N pieces of distance information are used to determine the flatness of the to-be-tested board, where N is an integer greater than 2.

Abstract: A method is disclosed that includes obtaining a seismic data set and a seismic wave propagation velocity model and approximating the seismic wave propagation velocity model as a plurality of layers each bounded by a first and second bounding depth. For each of the plurality of layers, the method includes: simulation of the propagation of a seismic wave through the layer using a two-way seismic wave propagation simulator; forming an over-determined system of linear equations relating at least one mono-frequency component of the seismic wave at the first depth to one mono-frequency component at the second depth; and determining a plurality of one-way seismic wave propagation operators by inverting the over-determined system of linear equations. The method further includes processing the seismic data set using the one-way seismic wave propagation. A system and a non-transitory computer readable medium for implementing the method are also disclosed.

Abstract: The present invention relates to the synthesis of new classes of sunscreen agents, the usage of such sunscreen agents to prepare sunscreen formulation materials aiming at reduction of sunscreen agents’ skin penetration. The whole purpose of this invention is to improve the biosafety of sunscreen products via our novel sunscreen materials and formulation technology to reduce or to eliminate skin penetration of sunscreen agents. The technology of this invention can be applied to cosmetics, pharmaceutical or insects’ repellant products.

Abstract: The present invention relates to a mucus adhesion drug delivery technology. The technology involves the preparation of materials consisting of mucus adhesive excipient polymer chemically bonded with drug molecules and delivery of the materials with fast disintegration tablet with enteric coating to intestine. The bonding between the excipient polymer and the drug molecules is either ionic bonds, covalent bonds, or metal coordination bonds. The test of the mucus adhesion drug delivery technology was carried out using a dog model. The test data indicated successful retaining of drug molecules on the intestine mucus resulting in not only dramatic extension of drug release time, but also great improvement in the bioavailability of the API.

Abstract: A method for determining a non-linear beamforming (NLBF) tuple is disclosed. The method includes receiving a seismic data set and discretizing the seismic data set into a plurality of NLBF sub-problems. The method includes solving a subset of the NLBF sub-problems with a non-linear optimizer to create final NLBF tuples. The method further includes periodically training a machine-learned model with a subset of the NLBF sub-problems and final NLBF tuples data and obtaining intermediate NLBF tuple predictions from the trained machine-learned model. The intermediate NLBF tuple predictions may be used as initial values in a non-linear optimizer to create final NLBF tuples or may be accepted as final NLBF tuples. The method includes storing the final NLBF tuples.

Abstract: The present invention relates to a sander, and a method for disassembling or installing a working head of the sander. The sander includes: a main body, including a housing, a motor disposed in the housing, a switch mechanism for controlling the motor includes a switch, and a drive component driven by the motor to rotate; and a working head adapted to the drive component. The main body further includes an interlocking mechanism, the interlocking mechanism includes an operation member movably disposed relative to the housing, the operation member is operably shifted between a first state and a second state, when the operation member is in the first state, the interlocking mechanism allows the switch to be triggered, when the switch is in a triggered state, the operation member is prevented from being shifted from the first state to the second state; and when the operation member is in the second state, the interlocking mechanism prevents the switch from being triggered.

Abstract: A method is disclosed that includes obtaining a seismic data set and a seismic wave propagation velocity model and approximating the seismic wave propagation velocity model as a plurality of layers each bounded by a first and second bounding depth. For each of the plurality of layers, the method includes: simulation of the propagation of a seismic wave through the layer using a two-way seismic wave propagation simulator; forming an over-determined system of linear equations relating at least one mono-frequency component of the seismic wave at the first depth to one mono-frequency component at the second depth; and determining a plurality of one-way seismic wave propagation operators by inverting the over-determined system of linear equations. The method further includes processing the seismic data set using the one-way seismic wave propagation. A system and a non-transitory computer readable medium for implementing the method are also disclosed.

Abstract: A spray gun includes a first shell, a fan module, a sleeve, a nozzle assembly and a spray bar assembly. The fan module includes a brushless motor. The sleeve is formed or mounted on the first shell. The nozzle assembly is disposed at an end of the sleeve. The spray bar assembly is received in the sleeve and configured to move along a longitudinal axis of the spray bar assembly to open or close the liquid outlet. The fan module has a maximum outer diameter D1 between 30 mm and 80 mm, and a rotation axis of the brushless motor is parallel to or coincident with the longitudinal axis of the spray bar assembly. In this way, the spray gun is more compact and consistent with ergonomics.

Abstract: The present invention relates to a base station for a cleaning robot to park in, where the cleaning robot includes a wiping board, and a flexible wiping member replaceably butts the wiping board to form a wiping surface to wipe a working surface on which the cleaning robot walks, where the base station includes: a storage module, configured to store a continuous wiping base material; and a feeding module, configured to drive a free end of the wiping base material to be conveyed to a cutting position, to cause the free end to be cut from the wiping base material to form the wiping member. The present invention has the following beneficial effects: After returning to the base station, the cleaning robot may automatically mount a wiping member without intervention by a user.

Abstract: The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for generating a velocity model and a density model for a subsurface region of a hydrocarbon reservoir. One method includes: receiving, by a data processing apparatus, a set of seismic data of the hydrocarbon reservoir; setting, by the data processing apparatus, an initial velocity model and an initial density model; generating, by the data processing apparatus, wavefields of the hydrocarbon reservoir based on the set of seismic data; selecting, by the data processing apparatus, a spatial direction; generating, by the data processing apparatus, a velocity gradient and a reflectivity gradient of the selected spatial direction based on the wavefields; and updating, by the data processing apparatus, the velocity model and the density model using the velocity gradient and the reflectivity gradient of the selected spatial direction.

Abstract: A medical drainage stent that includes a stent body, and a proximal portion and a distal portion that are located at two ends of the stent body for connecting a first tissue wall and a second tissue wall in a juxtaposing manner. The stent body is fixed between the first tissue wall and the second tissue wall to provide a drainage channel. The proximal portion of the stent has N extension portions, where a fixed end of the extension portion is fixedly connected with an edge of a proximal end of the stent body, and the other end of the extension portion is a free end in a free state. Structures of the N extension portions at least partially protrude from the stent body in a radial direction, so that the proximal portion of the stent is fixed on the first tissue wall, where N is a positive integer.

Abstract: A computer system receives a post-stack time-domain image having a first spectrum and representing one or more subsurface structures. The computer system reconstructs an increased-frequency version of the post-stack time-domain image using L0-constrained inversion and a least-squares mismatch ratio. The increased-frequency version of the post-stack time-domain image includes structural artifacts. The computer system removes the structural artifacts from the increased-frequency version of the post-stack time-domain image using singular value decomposition. The computer system combines the increased-frequency version of the post-stack time-domain image with the post-stack time-domain image using a weighting function. The computer system generates a combined version of the increased-frequency version of the post-stack time-domain image and the post-stack time-domain image. The combined version represents the one or more subsurface structures and has a second spectrum broader than the first spectrum.

Abstract: Systems and methods, including computer-implemented systems and methods, for determining an optimized geometry of seismic sources and receivers in order to generate a desired dense wavefield.

Abstract: The present invention relates to the technical field of hand-held tools. Disclosed is a hand-held power tool, comprising: a housing; a motor; a chuck assembly; and a transmission mechanism having a drive shaft. The chuck assembly comprises a main body, a jaw, and an adjustment member threadedly connected to the jaw. The power tool has a drilling mode in which the main body, the jaw and the adjustment member rotate together, and an auto chuck mode in which the adjustment member and the main body can rotate relative to each other to realize opening and closing of the jaw. The power tool further comprises a first supporting member and a second supporting member used to rotatably support the main body at the housing. The first supporting member and the second supporting member are at least partially overlapped with the jaw in an axial direction of the drive shaft, such that the power tool is structurally compact in the axial direction. The main body is provided with an accommodation cavity therein.

Abstract: The present invention relates to the synthesis of new classes of sunscreen agents, the usage of such sunscreen agents in sunscreen formulations aiming at reduction of sunscreen agents' skin penetration, and a formulation technology using existing sunscreen agents aiming at reduction of sunscreen agents' skin penetration, therefore improving the bio-safety of the sunscreen products.

Abstract: The present invention relates to the synthesis of new classes of sunscreen agents, the usage of such sunscreen agents in sunscreen formulations aiming at reduction of sunscreen agents' skin penetration, and a formulation technology using existing sunscreen agents aiming at reduction of sunscreen agents' skin penetration, therefore improving the bio-safety of the sunscreen products.

Abstract: A computer system receives a post-stack time-domain image having a first spectrum and representing one or more subsurface structures. The computer system reconstructs an increased-frequency version of the post-stack time-domain image using L0-constrained inversion and a least-squares mismatch ratio. The increased-frequency version of the post-stack time-domain image includes structural artifacts. The computer system removes the structural artifacts from the increased-frequency version of the post-stack time-domain image using singular value decomposition. The computer system combines the increased-frequency version of the post-stack time-domain image with the post-stack time-domain image using a weighting function. The computer system generates a combined version of the increased-frequency version of the post-stack time-domain image and the post-stack time-domain image. The combined version represents the one or more subsurface structures and has a second spectrum broader than the first spectrum.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating receiver deghosted output according to a receiver deghosting model.