Abstract: The present invention discloses a method for the preparation and application of modified extracellular vesicles specifically targeted to the kidneys. These modified extracellular vesicles are derived from fibroblastic reticular cells in the mesentery tissue and express anti-inflammatory proteins after being modified with anchor peptides. By combining the extracellular vesicles secreted from fibroblastic reticular cells in the mesentery tissue with anchor peptides, the present invention ensures the effective targeting of the exosomes to the kidneys. Additionally, through genetic engineering of fibroblastic reticular cells, the exosomes secreted by these cells can carry the target molecule, anti-inflammatory protein CD5L, achieving precise targeted therapy for the kidneys. This innovative treatment strategy holds promising potential for the treatment of sepsis-associated acute kidney injury, bringing positive impacts to patients' health.

Abstract: The present disclosure provides a method and a server for platooning. The method provides: obtaining, based on a platooning request message, a first vehicle type and first kinematic information of a vehicle to join a platoon, a second vehicle type and second kinematic information of a current tail of the platoon, first sensor operating status information of the vehicle to join the platoon, and second sensor operating status information of the current tail vehicle; performing vehicle kinematic determination to obtain a kinematic determination result; performing sensor determination to obtain a sensor determination result; transmitting a confirmation request message to a vehicle of the platoon when the determination results are both successful; and controlling, upon receiving a request approval message, the vehicle to join the platoon to establish a V2V communication connection with each vehicle in the platoon. The method can achieve platoon without any road side unit.

Abstract: The present invention discloses a multistage variable burning rate solid rocket motor and a forming method. A multi-material composite fiber skeleton structure is embedded inside a propellant in the present invention, so that the original burning rate of the propellant presents multistage changes to achieve the function of multistage thrust. The fiber skeleton structure embedded in the solid rocket motor is formed by additive manufacturing, fixed in a combustion chamber, and then charged at one time to complete the forming of a motor grain. The design can greatly increase the burning rates of the propellants of end-burning and bore-burning motors, and can also conduct multistage adjustment for the burning rates of the motors by changing the fiber skeleton and structure, so as to satisfy the requirements of missile weapon systems for multistage power propulsion. The present invention greatly simplifies the technological production process of the existing single-chamber multi-thrust motor.

Abstract: The present disclosure relates to the technical field of die casting machine devices, in particular to a digital die casting machine with mold temperature control, including: a die casting machine configured to die-cast a casting through a mold, a cooling flow control apparatus configured to control a mold temperature by controlling a cooling medium flow, a temperature collection apparatus configured to collect the mold temperature, a control cabinet configured to acquire and store data collected by the temperature collection apparatus and control operation of the die casting machine, the cooling flow control apparatus and an automatic control apparatus, an edge computer configured to execute a die casting temperature optimization strategy according to the collected data stored in the control cabinet, and the automatic control apparatus. The present disclosure improves the molding quality of castings by adjusting the mold temperature in a casting process.

Abstract: A single-domain antibody polypeptide specifically binding to VEGF C and a construct thereof, an anti-VEGF C/VEGF A bispecific binding protein, polynucleotides encoding the polypeptide and protein, an expression vector, a host cell, a pharmaceutical composition thereof, and a method and use for treating diseases related to neovascularization.

Abstract: The present disclosure provides a method and an apparatus for trailer angle measurement, as well as a vehicle, applied in a vehicle including a tractor and a trailer. At least one LiDAR is provided on each of two sides of the tractor. The method includes: obtaining, an initial trailer model containing initial point cloud data; controlling the to emit laser light; controlling each of the LiDARs to receive a corresponding point cloud reflected by the surface of the trailer; and calculating a trailer angle based on the point cloud data and the initial point cloud data using a point cloud matching algorithm. With the embodiments of the present disclosure, fast and accurate measurement of a trailer angle can be achieved with a simple structure.

Abstract: The present disclosure relates to Internet of Vehicles technology, and provides a method, an apparatus, and system for redundant communication for platooning. The method includes: transmitting application data to be transmitted to at least two V2V devices; and controlling the at least two V2V devices that have received the application data to transmit the application data to a predetermined air interface, such that a receiving apparatus obtains the application data from the air interface. With the redundant configuration of the V2V devices, the problem caused by communication failure of one single V2V device can be avoided, so as to ensure stability of V2V communication and guarantee safe operation for platooning.

Abstract: The present invention relates to an antibody directed against a vascular endothelial growth factor (VEGF/VEGF-A) and angiopoietin-2 (ANG-2), respectively, a bispecific binding molecule (e.g., an antibody) directed against the vascular endothelial growth factor (VEGF/VEGF-A) and angiopoietin-2 (ANG-2) simultaneously, a preparation method therefor, a pharmaceutical composition comprising the antibody or molecule, and use thereof.

Abstract: A method, a device, and a system for parking a truck accurately in a shore crane area are provided. A vehicle controller transmits a parking request for a truck to be parked. A main controller receives the parking request and acquires real-time point cloud data by scanning one or more lanes crossed by a shore crane using one or more LiDARs. The main controller clusters the real-time point cloud data to obtain a set of point clouds for the truck and applies an Iterative Closest Point algorithm to the set of point clouds and a vehicle point cloud model to obtain a real-time distance from the truck to a target parking space. The vehicle controller controls the truck to stop at the target parking space based on the real-time distance.

Abstract: The present disclosure provides a method, an apparatus and a vehicle for trailer angle measurement, applied in a semi-trailer including a tractor and a trailer. At least one LiDAR is provided on each of two sides of a rear part of the tractor. A reflector with a reflective surface is fixedly provided at a front part of the trailer, and the reflective surface faces the LiDARs. The method includes: controlling the LiDARs to emit laser light, such that the reflective surface of the reflector reflects the laser light; controlling each of the LiDARs to receive a corresponding laser point cloud reflected by the reflector; and calculating a trailer angle based on the corresponding laser point clouds. The method and apparatus can increase the range of trailer angle measurement, such that the trailer angle can be measured even if the trailer angle is relatively large.

Abstract: The present invention relates to novel antibodies and antibody fragments specifically binding to ANG-2 and compositions comprising said antibodies or antibody fragments thereof. In addition, the present invention relates to nucleic acids encoding the antibody or antibody fragments thereof and host cells containing the nucleic acids, and their related uses. Furthermore, the present invention relates to the therapeutic and diagnostic use of these antibodies and antibody fragments.

Abstract: The present disclosure provides a method and a server for platooning. The method provides: obtaining, based on a platooning request message, a first vehicle type and first kinematic information of a vehicle to join a platoon, a second vehicle type and second kinematic information of a current tail of the platoon, first sensor operating status information of the vehicle to join the platoon, and second sensor operating status information of the current tail vehicle; performing vehicle kinematic determination to obtain a kinematic determination result; performing sensor determination to obtain a sensor determination result; transmitting a confirmation request message to a vehicle of the platoon when the determination results are both successful; and controlling, upon receiving a request approval message, the vehicle to join the platoon to establish a V2V communication connection with each vehicle in the platoon. The method can achieve platoon without any road side unit.

Abstract: A waypoint information transmission method, apparatus and system for platooning are provided. An example method for transmitting waypoint information of a platooning comprises: receiving, by an apparatus for transmitting waypoint information in real time, waypoint information of each cycle sent by a leading vehicle-mounted apparatus mounted on a leading vehicle; storing, by the apparatus, the waypoint information of each cycle, so as to form historical waypoint information; receiving, by the apparatus, a waypoint information transmission control instruction sent by the leading vehicle-mounted apparatus, and determining, according to the waypoint information transmission control instruction, target waypoint information based on the historical waypoint information; and sending, by the apparatus, the target waypoint information to a first vehicle-mounted apparatus mounted on a first following vehicle that is following the leading vehicle and to be enqueued for the platooning.

Abstract: An image acquisition method and apparatus are provided. By controlling a motion device, at least one of an image acquisition device or a photographed target object moves under the driving of the motion device, so that a sample image including the target object can be acquired in a preset designated acquisition pose after movement, thereby improving the accuracy of a relative pose between the image acquisition device and the target object during acquisition, reducing human intervention during acquisition, improving the automation degree, and providing the possibility for subsequent services that need to be performed according to sample images captured with relatively high shooting pose accuracy.

Abstract: The invention relates to the field of aluminum wheel casting molds, and more particularly relates to a closed-loop control method and system for a mold temperature in a wheel casting process. The control method includes: step 1, acquiring data, that is, acquiring a plurality of mold position temperatures, and cooling pipeline opening and closing signals in a target wheel casting process according to a fixed frequency; step 2, storing, based on acquired mold opening and closing signals of casting equipment, the acquired data in a database in the form of a unique ID according to a single wheel casting process; step 3, calculating new process parameters based on the acquired plurality of position temperatures and time; and step 4, integrating the calculated process parameters, and issuing the process parameters to a PLC of a casting equipment to perform new casting.

Abstract: The present disclosure provides a method and a server for platooning. The method provides: obtaining, based on a platooning request message, a first vehicle type and first kinematic information of a vehicle to join a platoon, a second vehicle type and second kinematic information of a current tail of the platoon, first sensor operating status information of the vehicle to join the platoon, and second sensor operating status information of the current tail vehicle; performing vehicle kinematic determination to obtain a kinematic determination result; performing sensor determination to obtain a sensor determination result; transmitting a confirmation request message to a vehicle of the platoon when the determination results are both successful; and controlling, upon receiving a request approval message, the vehicle to join the platoon to establish a V2V communication connection with each vehicle in the platoon. The method can achieve platoon without any road side unit.

Abstract: Embodiments of this specification provide methods and apparatuses for performing model ownership verification based on an exogenous feature. An implementation of the methods includes: selecting initial samples from an initial sample set to form a selected sample set, processing sample data of the initial samples to obtain transform samples that form a transform sample set, training a meta-classifier based on a target model, an auxiliary model, and the transform sample set, inputting data associated with a suspicious model into the meta-classifier, and determining, based on an output result of the meta-classifier, whether the suspicious model is stolen from a deployment model, wherein the deployment model has feature knowledge of the exogenous feature.

Abstract: The invention relates to the field of aluminum wheel casting molds, and more particularly relates to a closed-loop control method and system for a mold temperature in a wheel casting process. The control method includes: step 1, acquiring data, that is, acquiring a plurality of mold position temperatures, and cooling pipeline opening and closing signals in a target wheel casting process according to a fixed frequency; step 2, storing, based on acquired mold opening and closing signals of casting equipment, the acquired data in a database in the form of a unique ID according to a single wheel casting process; step 3, calculating new process parameters based on the acquired plurality of position temperatures and time; and step 4, integrating the calculated process parameters, and issuing the process parameters to a PLC of a casting equipment to perform new casting.

Abstract: A method of controlling intra prediction for decoding or encoding of a video sequence, is performed by at least one processor and includes obtaining intra prediction modes including directional modes respectively corresponding to angular prediction directions, a first amount of one or more of the directional modes being excluded from the intra prediction modes based on a second amount of the intra prediction modes and a third amount of most probable modes (MPMs). The method further includes selecting, as the MPMs, two or more of the intra prediction modes from which the one or more of the directional modes are excluded, and selecting, for decoding the video sequence, one of the intra prediction modes from which the one or more of the directional modes are excluded.

Abstract: The present disclosure provides a method, a device, and a system for parking a truck. The method includes a main controller acquiring real-time point cloud data by scanning a lane crossed by a shore crane using a laser radar; the main controller clustering the real-time point cloud data to obtain a set of point clouds for the truck moving in the lane; and the main controller obtaining a real-time distance from the moving truck to a target parking space based on the set of point clouds and a vehicle point cloud model; the main controller broadcasting a message containing the real-time distance, such that a vehicle controller controls the moving truck to stop at the target parking space based on the real-time distance contained in the message.