Patents by Inventor Yi-Ming Zhang

Yi-Ming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric and/or growth-restricted flaviviruses
    Patent number: 6676936
    Abstract: The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus. The invention also includes a baculovirus having a recombinant dengue cDNA sequence which encodes: (1) dengue virus capsid protein, pre-matrix protein, envelope glycoprotein and NS1 and NS2a nonstructural proteins or (2) dengue envelope glycoprotein or (3) dengue non-structural proteins NS1 and NS2a.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: January 13, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services.
    Inventors: Ching-Juh Lai, Michael Bray, Alexander G. Pletnev, Ruhe Men, Yi-Ming Zhang, Kenneth H. Eckels, Robert M. Chanock
  • Chimeric and/or growth-restricted flaviviruses
    Patent number: 6184024
    Abstract: The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus. The invention also includes a baculovirus having a recombinant dengue cDNA sequence which encodes: (1) dengue virus capsid protein, pre-matrix protein, envelope glycoprotein and NS1 and NS2a nonstructural proteins or (2) dengue envelope glycoprotein or (3) dengue non-structural proteins NS1 and NS2a.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: February 6, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ching-Juh Lai, Michael Bray, Alexander G. Pletnev, Ruhe Men, Yi-Ming Zhang, Kenneth H. Eckels, Robert M. Chanock