Patents by Inventor Yinan Kan

Yinan Kan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
    Publication number: 20240084322
    Abstract: The present disclosure relates to cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. In addition, the present disclosure relates to methods of making and using the cells, tissues, organs, and/or animals having one or more of the modified genes.
    Type: Application
    Filed: June 1, 2023
    Publication date: March 14, 2024
    Inventors: Jacob LAYER, Wenning QIN, Yinan KAN, Juliet CRABTREE, Michele YOUD, David HEJA, David ANGELES ALBORES, Ranjith ANAND, Paola PERRAT, Russell ERNST, Violette PARAGAS
  • METHODS AND COMPOSITIONS FOR PRODUCTION OF XENOGENEIC ISLET CELLS AND TREATMENT OF INSULIN-RESISTANT OR -DEFICIENT CONDITIONS WITH THE SAME
    Publication number: 20230056661
    Abstract: Described here are methods, compositions, and systems for generating transgenic islet cells suitable for xenotransplantation.
    Type: Application
    Filed: January 7, 2021
    Publication date: February 23, 2023
    Inventors: Yangbin GAO, Yanan YUE, Luhan YANG, Marc GUELL, Yinan KAN, Wenning QIN
  • CELLS, TISSUES, ORGANS, AND/OR ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND/OR TOLERANCE
    Publication number: 20220267805
    Abstract: Provided are cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance. And methods of producing and using the cells, tissues, organs, and/or animals.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 25, 2022
    Inventors: Luhan YANG, Yangbin GAO, Marc GUELL, Yinan KAN, Wenning QIN
  • Methods of Genetic Modification of a Cell
    Publication number: 20190380314
    Abstract: The disclosure provides a method of modifying a PERV-A receptor gene in a cell. The method includes introducing into the cell a nucleic acid sequence encoding a Cas9 protein and a nucleic acid sequence encoding a guide RNA, introducing into the cell a donor nucleic acid sequence, wherein the Cas9 protein and the guide RNA are expressed and co-localize at a genomic site near or in the PERV-A receptor gene and the donor nucleic acid sequence replaces the PERV-A receptor gene by homology directed repair (HDR).
    Type: Application
    Filed: February 23, 2018
    Publication date: December 19, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Ellen L. Shrock, Yinan Kan