Abstract: The embodiments of the present disclosure provide an antibody or antigen-binding fragment against SARS-CoV-2 spike(S) protein, comprising: three complementarity determining regions (HCDRs) of a heavy chain variable region or one or more variants thereof, the heavy chain variable region set forth as SEQ ID NO. 30 or SEQ ID NO. 46, each of the one or more variants having at most two amino acid changes compared to the corresponding CDR; and three complementarity determining regions (LCDRs) of a light chain variable region or one or more variants thereof, the light chain variable region set forth as SEQ ID NO. 32 or SEQ ID NO. 48, each of the one or more variants having at most two amino acid changes compared to the corresponding CDR.

Abstract: A target-directed, magnetically enhanced system and method for detoxification of patients. The system comprises a first fluid circuit for circulation of biological fluid and a second fluid circuit for co-circulation of biological fluid. The first fluid circuit comprises, in the following order: a first fluid circuit inlet (10), a reaction chamber (2), an equipment comprising one or more elements that separate the magnetic microspheres from the biological fluid, and a first fluid circuit outlet (13). The second fluid circuit initiates after the first fluid circuit inlet (10) and terminates before the first fluid circuit outlet (13). The system and method can be used to quickly and effectively remove toxins, infectious agents, allergens, cancer cells, and other unwanted substances from a patient, and provide extracorporeal blood or plasma treatment.