Patents by Inventor Yinfa Yan

Yinfa Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Use Thereof
    Publication number: 20230130361
    Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.
    Type: Application
    Filed: November 21, 2022
    Publication date: April 27, 2023
    Inventors: Yinfa Yan, Minsheng Zhang, Dong Liu, Fengqi Zhang, Suxing Liu, Rumin Zhang, Feng He, Weikang Tao
  • Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ROR?) and pharmaceutical uses thereof
    Patent number: 11512055
    Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: November 29, 2022
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Yinfa Yan, Minsheng Zhang, Dong Liu, Fengqi Zhang, Suxing Liu, Rumin Zhang, Feng He, Weikang Tao
  • COMPOUNDS AS BRUTON TYROSINE KINASE INHIBITORS, PREPARATION METHODS AND MEDICAL APPLICATIONS THEREOF
    Publication number: 20220169645
    Abstract: This application discloses Bruton Tyrosine Kinase (BTK) inhibitors of the general formula (IM) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of various disorders related to the excessive BTK activity, including cancers, immune disorders, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders, and neurological disorders.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 2, 2022
    Inventors: Puhui Li, Yinfa Yan, Jian Liu, Dong Liu, Chunying Song, Suxing Liu
  • TYROSINE KINASE 2 INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
    Publication number: 20220009910
    Abstract: This application discloses Tyk-2 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, method of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with Tyk-2 activity, such as autoimmune diseases and cancers.
    Type: Application
    Filed: July 10, 2021
    Publication date: January 13, 2022
    Inventors: Linghang Zhuang, Jian Liu, Yinfa Yan, Puhui Li, Yu Zhou, Suxing Liu
  • Benzimidazole Derivatives as Modulators of Retinoid-Related Orphan Receptor Gamma (RORy) and Pharmaceutical Uses Thereof
    Publication number: 20210171471
    Abstract: The present invention relates to benzimidazole derivatives of formula (I) as inhibitors of retinoid-related orphan receptor gamma (ROR?) protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR?-mediated diseases or disorders.
    Type: Application
    Filed: May 3, 2019
    Publication date: June 10, 2021
    Inventors: Yinfa Yan, Minsheng Zhang, Dong Liu, Fengqi Zhang, Suxing Liu, Rumin Zhang, Feng He, Weikang Tao
  • Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors
    Patent number: 10144737
    Abstract: The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: December 4, 2018
    Assignee: JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Minsheng Zhang, Yinfa Yan
  • SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS
    Publication number: 20170114063
    Abstract: The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 27, 2017
    Applicant: ETERNITY BIOSCIENCE INC.
    Inventors: Minsheng Zhang, Yinfa YAN
  • Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation
    Publication number: 20100168106
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7705030
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: April 27, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-5,5-diphenylimidazolone derivatives for the inhibition of ?-secretase
    Patent number: 7700602
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: April 20, 2010
    Assignee: Wyeth LLC
    Inventors: Michael S. Malamas, James J. Erdei, Iwan S. Gunawan, Ping Zhou, Yinfa Yan, Dominic A. Quagliato
  • HETEROCYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
    Publication number: 20090253711
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: June 12, 2009
    Publication date: October 8, 2009
    Applicant: Wyeth
    Inventors: Ronald Charles Bernotas, Yinfa Yan, Albert Jean Robichaud, Guangcheng Liu
  • Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7576087
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: August 18, 2009
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Yinfa Yan
  • Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
    Patent number: 7560470
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: July 14, 2009
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Yinfa Yan, Albert Jean Robichaud, Guangcheng Liu
  • AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090093498
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: December 10, 2008
    Publication date: April 9, 2009
    Applicant: Wyeth
    Inventors: Michael S. Malamas, James J. Erdei, Iwan S. Gunawan, Ping Zhou, Yinfa Yan, Dominic A. Quagliato
  • Amino-5,5-diphenylimidazolone derivatives for the inhibition of ?-secretase
    Patent number: 7482349
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: January 27, 2009
    Assignee: Wyeth
    Inventors: Michael S. Malamas, James J. Erdei, Iwan S. Gunawan, Ping Zhou, Yinfa Yan, Dominic A. Quagliato
  • AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION
    Publication number: 20080306091
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: July 28, 2008
    Publication date: December 11, 2008
    Applicant: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7417047
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 26, 2008
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Indolylalkylpyridin-2-amines for the inhibition of beta-secretase
    Publication number: 20080076801
    Abstract: The present invention provides an indolylalkylpyridin-2-amine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 27, 2008
    Applicant: Wyeth
    Inventors: Yinfa Yan, Ping Zhou, Yi Fan, Albert Robichaud, Michael Malamas
  • Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20080015201
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: June 19, 2007
    Publication date: January 17, 2008
    Applicant: Wyeth
    Inventors: Ronald Bernotas, Yinfa Yan
  • Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20070232618
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: May 15, 2007
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: Ronald Bernotas, Yinfa Yan, Albert Robichaud, Guangcheng Liu