Abstract: A rapid sintering system and rapid sintering method, the rapid sintering system comprising: a furnace body (110) comprising a hearth (111) and a furnace mouth (112) that communicate with each other; a lifting device (120) arranged below the furnace mouth (112), comprising a support (122) and a sample stage (121), the sample stage (121) being disposed on the support (122); a temperature acquisition device (130), disposed on the sample stage (121); a control device (140), disposed outside of the hearth (111), electrically connected to the lifting device (120) and the temperature acquisition device (130) and used to control lifting of the lifting device (120) according to a temperature acquired by the temperature acquisition device (130) and a preset sintering condition; and a spacer (150), disposed at a first end of the lifting device (120), a first spacing being present between the spacer (150) and the sample stage (121), and the furnace mouth (112) is blocked by the spacer (150) when the rapid sintering syste

Abstract: The present disclosure provides methods and compositions for the treatment of cancer using an ACAT1 inhibitor in combination with an immune checkpoint inhibitor. The immune checkpoint inhibitor may inhibit the programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation protein 3 (LAG-3), or combinations thereof. The ACAT1 inhibitor may be avasimibe, pactimibe, or purpactins, without limitation.

Abstract: The present disclosure provides antibodies that bind to OX40 and antigen binding fragments thereof, and use of the antibodies and the antigen binding fragments in the treatment of diseases for example cancers. The antibodies or the antigen binding fragments include a heavy chain variable region including one or more CDRs having an amino acid sequence selected from amino acid sequences as set forth in SEQ ID NOs: 1-12.

Abstract: Systems and methods are disclosed for simulating microvascular networks from a vascular tree model to simulate tissue perfusion under various physiological conditions to guide diagnosis or treatment for cardiovascular disease. One method includes: receiving a patient-specific vascular model of a patient's anatomy, including a vascular network; receiving a patient-specific target tissue model in which a blood supply may be estimated; receiving joint prior information associated with the vascular model and the target tissue model; receiving data related to one or more perfusion characteristics of the target tissue; determining one or more associations between the vascular network of the patient-specific vascular model and one or more perfusion characteristics of the target tissue using the joint prior information; and outputting a vascular tree model that extends to perfusion regions in the target tissue, using the determined associations between the vascular network and the perfusion characteristics.

Abstract: Implementations of the subject technology provide visualizations of non-visible features of a physical environment, at the location of the non-visible features in the physical environment. The non-visible features may include wireless communications signals, sounds, airflow, gases, subsonic and/or ultrasonic waves, hidden objects, or the like. A device may store visual contexts for visualizations of particular non-visible features. The device may obtain a depth map that allows the device to determine the location of the non-visible feature in the physical environment and to overlay the visualization on a user's view of that location. In this way, the non-visible feature can be visualized its correct location, orientation, direction and/or strength in the physical environment.

Abstract: Systems and methods are disclosed for correcting for artificial deformations in anatomical modeling. One method includes obtaining an anatomic model; obtaining information indicating a presence of an artificial deformation of the anatomic model; identifying a portion of the anatomic model associated with the artificial deformation; estimating a non-deformed local area corresponding to the portion of the anatomic model; and modifying the portion of the anatomic model associated with the artificial deformation, based on the estimated non-deformed local area.

Abstract: Implementations of the subject technology provide visualizations of non-visible features of a physical environment, at the location of the non-visible features in the physical environment. The non-visible features may include wireless communications signals, sounds, airflow, gases, subsonic and/or ultrasonic waves, hidden objects, or the like. A device may store visual contexts for visualizations of particular non-visible features. The device may obtain a depth map that allows the device to determine the location of the non-visible feature in the physical environment and to overlay the visualization on a user's view of that location. In this way, the non-visible feature can be visualized its correct location, orientation, direction and/or strength in the physical environment.

Abstract: Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient’s anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

Abstract: Systems and methods are disclosed for simulating microvascular networks from a vascular tree model to simulate tissue perfusion under various physiological conditions to guide diagnosis or treatment for cardiovascular disease. One method includes: receiving a patient-specific vascular model of a patient's anatomy, including a vascular network; receiving a patient-specific target tissue model in which a blood supply may be estimated; receiving joint prior information associated with the vascular model and the target tissue model; receiving data related to one or more perfusion characteristics of the target tissue; determining one or more associations between the vascular network of the patient-specific vascular model and one or more perfusion characteristics of the target tissue using the joint prior information; and outputting a vascular tree model that extends to perfusion regions in the target tissue, using the determined associations between the vascular network and the perfusion characteristics.

Abstract: A pin-on-plate friction and wear test device includes a high temperature heating chamber and a cooling pin. The high temperature heating chamber is fastened horizontally to the mobile base. The axis of the cooling pin is perpendicular to the upper surface of the mobile base. The electric resistance heating plate is located in the bottom closed space under the friction sample plate in the high temperature heating chamber. The electric resistance heats the fixed sample to experiment temperature. The inner layout of pin is a circling cooling channel where the cooling medium adjusts and cools the temperature of the sample. Thermocouples are separately distributed in the temperature measuring groove of the high temperature heating chamber and the temperature measuring hole of the cooling pin for real-time temperature measurement. The device can simulate the friction and wear properties of the high-strength steel plate and hot-stamping die in the differential temperature environment.

Abstract: A high-efficiency particle analysis method includes the following steps: taking representative air-dried samples and measuring a moisture content; boiling, sieving, weighing and adding a dispersant; conducting a particle analysis test; reading four readings of 1st to 59th and 60th to 90th samples; and drawing a particle size distribution curve showing the relationship between the particle size and the percentage of below a certain diameter. According to the method, a time difference is used to change the measurement mode, and the four readings of the 59th and 90th samples are read in a cycling manner; and a novel test method is provided on the premise of ensuring quality, thus greatly improving the efficiency of a particle analysis test and meeting production requirements.

Abstract: Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

Abstract: Systems and methods are disclosed for correcting for artificial deformations in anatomical modeling. One method includes obtaining an anatomic model; obtaining information indicating a presence of an artificial deformation of the anatomic model; identifying a portion of the anatomic model associated with the artificial deformation; estimating a non-deformed local area corresponding to the portion of the anatomic model; and modifying the portion of the anatomic model associated with the artificial deformation, based on the estimated non-deformed local area.

Abstract: The present disclosure provides antibodies that bind to OX40 and antigen binding fragments thereof, and use of the antibodies and the antigen binding fragments in the treatment of diseases for example cancers. The antibodies or the antigen binding fragments include a heavy chain variable region including one or more CDRs having an amino acid sequence selected from amino acid sequences as set forth in SEQ ID NOs: 1-12.

Abstract: A pin-on-plate friction and wear test device includes a high temperature heating chamber and a cooling pin. The high temperature heating chamber is fastened horizontally to the mobile base. The axis of the cooling pin is perpendicular to the upper surface of the mobile base. The electric resistance heating plate is located in the bottom closed space under the friction sample plate in the high temperature heating chamber. The electric resistance heats the fixed sample to experiment temperature. The inner layout of pin is a circling cooling channel where the cooling medium adjusts and cools the temperature of the sample. Thermocouples are separately distributed in the temperature measuring groove of the high temperature heating chamber and the temperature measuring hole of the cooling pin for real-time temperature measurement. The device can simulate the friction and wear properties of the high-strength steel plate and hot-stamping die in the differential temperature environment.

Abstract: Resilient members having near-surface architectures including microstructures for controlling friction are provided. A film-terminated array of fibrils having a sharp film/fibril juncture exhibits an unexpectedly large enhancement of adhesion, static friction and sliding friction. The enhancement is provided against rough indenters. A film-terminated array of elongated ridges and valleys unexpectedly exhibits low adhesion, and an unexpectedly large enhancement of sliding friction. The film-terminated ridge/valley design provides an anisotropic structure with direction-dependent frictional properties. The increase in sliding friction force varies as a function of interfibrillar spacing, and corresponds to a mode in which buckling of the terminal film occurs. The near surface architectures may be designed with varying scales and varying parameters to provide performance characteristics tailored to various applications.

Abstract: Implementations of the subject technology provide visualizations of non-visible features of a physical environment, at the location of the non-visible features in the physical environment. The non-visible features may include wireless communications signals, sounds, airflow, gases, subsonic and/or ultrasonic waves, hidden objects, or the like. A device may store visual contexts for visualizations of particular non-visible features. The device may obtain a depth map that allows the device to determine the location of the non-visible feature in the physical environment and to overlay the visualization on a user's view of that location. In this way, the non-visible feature can be visualized its correct location, orientation, direction and/or strength in the physical environment.

Abstract: Implementations of the subject technology provide visualizations of non-visible features of a physical environment, at the location of the non-visible features in the physical environment. The non-visible features may include wireless communications signals, sounds, airflow, gases, subsonic and/or ultrasonic waves, hidden objects, or the like. A device may store visual contexts for visualizations of particular non-visible features. The device may obtain a depth map that allows the device to determine the location of the non-visible feature in the physical environment and to overlay the visualization on a user's view of that location. In this way, the non-visible feature can be visualized its correct location, orientation, direction and/or strength in the physical environment.

Abstract: A query on a data is received. One or more granularity of data is determined of the data to respond to the query. The one or more granularity of data includes a low granularity data and a high granularity data. Whether the low granularity data is stored in a cache is determined. Responsive to determining the low granularity data is stored in the cache, the low granularity data is retrieved. The low granularity data is displayed.

Abstract: Systems and methods are disclosed for correcting for artificial deformations in anatomical modeling. One method includes obtaining an anatomic model; obtaining information indicating a presence of an artificial deformation of the anatomic model; identifying a portion of the anatomic model associated with the artificial deformation; estimating a non-deformed local area corresponding to the portion of the anatomic model; and modifying the portion of the anatomic model associated with the artificial deformation, based on the estimated non-deformed local area.