Abstract: The subject invention pertains to a long-term antigen depot that can bypass FBR and engage DCs to mature and migrate to lymph nodes to activate antigen-specific T-cell activations. Leveraging on the immunomodulatory properties of exogenous polysaccharides and the anti-fouling characteristics of zwitterionic phosphorylcholine (PC) polymer, the invention features a PC functionalized dextran (PCDX) hydrogel for long-term antigen delivery. PCDX in both injectable scaffold and microparticles (MPs) forms effectively evades FBR and provides slow release of antigens resulting in local enrichment of CD11c+ DCs at the MPs injection sites. DC cultured on PCDX exhibits strong immunogenic activation with high CD86, CD40, MHC-I/peptide complex. PCDX also generates DC with propensity in migration to lymph nodes, as well as antigen presentation to trigger both CD4+ and CD8+ arms of T-cell responses.

Abstract: A lipophilic anchor includes a conjugation domain linked via a linker domain to an anchor domain having a plurality of hydrophobic tails. This lipophilic anchor allows deposition of at least one lipophilic target molecule with affinity for the anchor domain on a hydrophilic surface conjugated to the conjugation domain. The lipophilic target molecule coated hydrophilic substrate has the conjugation domain of the lipophilic anchor bound to the hydrophilic surface of a substrate and lipophilic target molecules are non-covalently bound to the anchor domain.

Abstract: A user exercise detection method applicable in a robot includes: obtaining first measurement data from at least one inertial measurement unit (IMU) sensor that is arranged at a designated body part of the user, and detecting a posture of the user relative to the robot based on the first measurement data; obtaining second measurement data from the at least one IMU sensor, and determining whether an exercise of the user corresponding to the posture is detected according to a preset threshold parameter and the second measurement data; in response to detection of the exercise, obtaining exercise data when the user performs the exercise multiple times through the at least one IMU sensor; and adjusting the threshold parameter according to the exercise data.

Abstract: The present disclosure provides compositions and methods for controlled release of macromolecules (such as proteins and polypeptides). The present disclosure also provides method for preparing and using the same.

Abstract: The present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel and methods for making and using the same. More specifically, the present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel with prolonged mucosal retention, and methods for making and using the same.

Abstract: The present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel and methods for making and using the same. More specifically, the present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel with prolonged mucosal retention, and methods for making and using the same.

Abstract: A touch sensing method and a serial manipulator using the same are disclosed. A serial manipulator using the method may detect and localize external torques by obtaining a torque value of each joint of a serial manipulator through a torque sensor at the joint; obtaining a preset joint angle of each joint from the serial manipulator; calculating a Jacobian matrices of the serial manipulator based on the joint angle of the joints; estimating joint torques of the serial manipulator based on the torque value of each joint and the Jacobian matrices; calculating an error between the torque value of each joint and the estimated joint torque corresponding to the joint; and determining a link of the serial manipulator that is connected to the joint with the minimum calculated error as having been touched.

Abstract: One or more computer processors receive a pattern string comprising a pointer to a pattern search point and a string comprising a pointer to a search point; determine a plausible search point within the string for the pattern character; execute a search string (SRST) instruction with the determined search point and the pattern character; compute a pattern offset comprising a difference between a first occurrence of the determined pattern character located within the pattern string but not in the correct position and a current pattern character position; execute a subsequent SRST instruction with the current pattern character position and the computed offset set as a new search point; and responsive to identifying all pattern characters in the correct position within the string based on the executed subsequent SRST instruction, transmit memory address associated with a substring comprised of the string and corresponding pattern characters in the correct position.

Abstract: A touch sensing method and a serial manipulator using the same are disclosed. A serial manipulator using the method may detect and localize external torques by obtaining a torque value of each joint of a serial manipulator through a torque sensor at the joint; obtaining a preset joint angle of each joint from the serial manipulator; calculating a Jacobian matrices of the serial manipulator based on the joint angle of the joints; estimating joint torques of the serial manipulator based on the torque value of each joint and the Jacobian matrices; calculating an error between the torque value of each joint and the estimated joint torque corresponding to the joint; and determining a link of the serial manipulator that is connected to the joint with the minimum calculated error as having been touched.

Abstract: Provided are compositions and methods for controlled release of macromolecules (such as proteins and polypeptides). The composition comprises at least a first hydrogel forming polymer and at least a second hydrogel forming polymer. Also provided are methods for preparing and using the composition.

Abstract: One or more computer processors receive a pattern string comprising a pointer to a pattern search point and a string comprising a pointer to a search point; determine a plausible search point within the string for the pattern character; execute a search string (SRST) instruction with the determined search point and the pattern character; compute a pattern offset comprising a difference between a first occurrence of the determined pattern character located within the pattern string but not in the correct position and a current pattern character position; execute a subsequent SRST instruction with the current pattern character position and the computed offset set as a new search point; and responsive to identifying all pattern characters in the correct position within the string based on the executed subsequent SRST instruction, transmit memory address associated with a substring comprised of the string and corresponding pattern characters in the correct position.

Abstract: An eyedrop composition, and methods of making and using the same, may include one or more hydrogel forming polymer having an intrinsic viscosity [?] of at least 3 dL/g in the composition, wherein a concentration CT of such hydrogel forming polymer in the composition is at most about 5 mg/mL.

Abstract: The present disclosure provides compositions and methods for controlled release of macromolecules (such as proteins and polypeptides). The present disclosure also provides method for preparing and using the same.

Abstract: The present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel and methods for making and using the same. More specifically, the present disclosure provides compositions comprising one or more polymers capable of forming a hydrogel with prolonged mucosal retention, and methods for making and using the same.

Abstract: Techniques are described for detecting anomalous behavior in program execution. In one example, a method includes logging occurrence of one or more key run time events during execution of a program. Each key run time event has a corresponding key run time event data structure associated with the program, and logging includes storing records associated with the key run time events, wherein each record is based on the key run time event data structure associated with the key run time event. The method further includes analyzing the records to determine if a current pattern of key run time events associated with the program during execution matches an expected pattern of key run time events and generating a security alert if the current pattern of key run time events does not match the expected pattern of key run time events for the program.

Abstract: A method for searching for multiple sub-strings of an original text is provided. A search query is received, wherein the search query includes a plurality of sub-strings. A hash array is allocated. The hash array has a size based, at least in part, on the plurality of sub-strings and an original text. The hash array is populated with a plurality of hash values, wherein the plurality of hash values are generated using a rolling hash function, and wherein each of the plurality of hash values corresponds to a portion of the original text. A plurality of sub-string values are computed based on the plurality of sub-strings. Each of the plurality of sub-strings are determined to occur in the original text based, at least in part, on searching the hash array for the plurality of sub-string values.

Abstract: A method for searching for multiple sub-strings of an original text is provided. A search query is received, wherein the search query includes a plurality of sub-strings. A hash array is allocated. The hash array has a size based, at least in part, on the plurality of sub-strings and an original text. The hash array is populated with a plurality of hash values, wherein the plurality of hash values are generated using a rolling hash function, and wherein each of the plurality of hash values corresponds to a portion of the original text. A plurality of sub-string values are computed based on the plurality of sub-strings. Each of the plurality of sub-strings are determined to occur in the original text based, at least in part, on searching the hash array for the plurality of sub-string values.

Abstract: Techniques are described for detecting anomalous behavior in program execution. In one example, a method includes logging occurrence of one or more key run time events during execution of a program. Each key run time event has a corresponding key run time event data structure associated with the program, and logging includes storing records associated with the key run time events, wherein each record is based on the key run time event data structure associated with the key run time event. The method further includes analyzing the records to determine if a current pattern of key run time events associated with the program during execution matches an expected pattern of key run time events and generating a security alert if the current pattern of key run time events does not match the expected pattern of key run time events for the program.

Abstract: Methods and systems for cross-language program execution include setting a signature of a second programming language in a first program that is written in a first programming language. A second program that is written in the second programming language is called from the first program, such that the second program omits checks to verify a runtime environment for the second programming language based on the presence of the signature.

Abstract: Methods and systems for cross-language program execution include setting a signature of a second programming language in a first program that is written in a first programming language. A second program that is written in the second programming language is called from the first program, such that the second program omits checks to verify a runtime environment for the second programming language based on the presence of the signature.