Patents by Inventor Ying Cheung

Ying Cheung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyanine compounds and their application as quenching compounds
    Publication number: 20140295437
    Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.
    Type: Application
    Filed: December 17, 2013
    Publication date: October 2, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Rosaria HAUGLAND, Ching-Ying CHEUNG, Stephen YUE
  • Transaction rate limiting
    Patent number: 8819252
    Abstract: Transaction rate limiting is provided to monitor new connections. If the number of new connections requested by a particular client exceeds a predetermined threshold value, then the client may be frozen out for a configured period of time. By denying access for the configured period of time, the client is prevented from monopolizing a particular client. Additionally, if the client does have malicious intent, a denial of service attack may be thwarted. The denial of service may be accomplished without alerting the client. This prevents a malicious client from regrouping and attempting an assault via a different mechanism.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: August 26, 2014
    Assignee: Foundry Networks, LLC
    Inventors: Ronald W. Szeto, David Chun Ying Cheung, Rajkumar Jalan, Sridhar J. Devarapalli
  • Substituted anthraquinone dyes for cellular stains and enzyme detection
    Patent number: 8790892
    Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: July 29, 2014
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Lori Michelle Roberts
  • Chemical probe compounds that become fluorescent upon reduction, and methods for their use
    Publication number: 20140127679
    Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
    Type: Application
    Filed: August 26, 2013
    Publication date: May 8, 2014
    Applicant: Life Technologies Corporation
    Inventors: Ching-Ying CHEUNG, Diane Gray, Stephen Yue
  • Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules
    Patent number: 8709830
    Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: April 29, 2014
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Hye Eun Hoover
  • MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES
    Publication number: 20140094608
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Application
    Filed: September 18, 2013
    Publication date: April 3, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Wai-Yee LEUNG, Ching-Ying Cheung, Stephen Yue
  • Fluorescent pyrene compounds
    Patent number: 8658434
    Abstract: The present invention relates to fluorescent pyrene dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: February 25, 2014
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung
  • GLOBAL SERVER LOAD BALANCING
    Publication number: 20140040478
    Abstract: A global server load balancing (GSLB) switch serves as a proxy to an authoritative DNS communicates with numerous site switches which are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics that include the information collected from the site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.
    Type: Application
    Filed: June 24, 2013
    Publication date: February 6, 2014
    Inventors: Ivy Pei-Shan Hsu, David Chun-Ying Cheung, Rajkumar Ramniranjan Jalan
  • Connection Rate Limiting For Server Load Balancing And Transparent Cache Switching
    Publication number: 20140025772
    Abstract: Each service in a computer network may have a connection rate limit. The number of new connections per time period may be limited by using a series of rules. In a specific embodiment of the present invention, a counter is increased each time a server is selected to handle a connection request. For each service, connections coming in are tracked. Therefore, the source of connection-request packets need not be examined. Only the destination service is important. This saves significant time in the examination of the incoming requests. Each service may have its own set of rules to best handle the new traffic for its particular situation. For server load balancing, a reset may be sent to the source address of the new connection request. For transparent cache switching, the connection request maybe forwarded to the Internet.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 23, 2014
    Applicant: Brocade Communications Systems, Inc.
    Inventors: Ronald W. Szeto, David Chun Ying Cheung, Rajkumar Jalan
  • XANTHENE DYES COMPRISING A SULFONAMIDE GROUP
    Publication number: 20140011208
    Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Application
    Filed: April 9, 2013
    Publication date: January 9, 2014
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Ching-Ying Cheung
  • Modified carbocyanine dyes and their conjugates
    Patent number: 8614302
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: December 24, 2013
    Assignee: Life Technologies Corporation
    Inventors: Ching-Ying Cheung, Stephen Yue, Wai-Yee Leung
  • Modified carbocyanine dyes and their conjugates
    Patent number: 8569506
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: October 29, 2013
    Assignee: Life Technologies Corporation
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Connection rate limiting for server load balancing and transparent cache switching
    Patent number: 8572228
    Abstract: Each service in a computer network may have a connection rate limit. The number of new connections per time period may be limited by using a series of rules. In a specific embodiment of the present invention, a counter is increased each time a server is selected to handle a connection request. For each service, connections coming in are tracked. Therefore, the source of connection-request packets need not be examined. Only the destination service is important. This saves significant time in the examination of the incoming requests. Each service may have its own set of rules to best handle the new traffic for its particular situation. For server load balancing, a reset may be sent to the source address of the new connection request. For transparent cache switching, the connection request may be forwarded to the Internet.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: October 29, 2013
    Assignee: Foundry Networks, LLC
    Inventors: Ronald W. Szeto, David Chun Ying Cheung, Rajkumar Jalan
  • Connection rate limiting for server load balancing and transparent cache switching
    Patent number: 8554929
    Abstract: Each service in a computer network may have a connection rate limit. The number of new connections per time period may be limited by using a series of rules. In a specific embodiment of the present invention, a counter is increased each time a server is selected to handle a connection request. For each service, connections coming in are tracked. Therefore, the source of connection-request packets need not be examined. Only the destination service is important. This saves significant time in the examination of the incoming requests. Each service may have its own set of rules to best handle the new traffic for its particular situation. For server load balancing, a reset may be sent to the source address of the new connection request. For transparent cache switching, the connection request may be forwarded to the Internet.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: October 8, 2013
    Assignee: Foundry Networks, LLC
    Inventors: Ronald W. Szeto, David Chun Ying Cheung, Rajkumar Jalan
  • Chemical probe compounds that become fluorescent upon reduction, and methods for their use
    Patent number: 8546580
    Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: October 1, 2013
    Assignee: Life Technologies Corporation
    Inventors: Ching-Ying Cheung, Diane Gray, Stephen Yue
  • Methine-Substituted Cyanine Dye Compounds
    Publication number: 20130252842
    Abstract: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
    Type: Application
    Filed: May 24, 2013
    Publication date: September 26, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jason DALLWIG, David Hagen, Ching-Ying Cheung, Gerald Thomas, Stephen Yue
  • Global server load balancing
    Patent number: 8504721
    Abstract: A global server load balancing (GSLB) switch serves as a proxy to an authoritative DNS communicates with numerous site switches which are coupled to host servers serving specific applications. The GSLB switch receives from site switches operational information regarding host servers within the site switches neighborhood. When a client program requests a resolution of a host name, the GSLB switch, acting as a proxy of an authoritative DNS, returns one or more ordered IP addresses for the host name. The IP addresses are ordered using metrics that include the information collected from the site switches. In one instance, the GSLB switch places the address that is deemed “best” at the top of the list.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: August 6, 2013
    Assignee: Brocade Communications Systems, Inc.
    Inventors: Ivy Pei-Shan Hsu, David Chun-Ying Cheung, Rajkumar Ramniranjan Jalan
  • Methine-substituted cyanine dye compounds
    Patent number: 8470529
    Abstract: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: June 25, 2013
    Assignee: Life Technologies Corporation
    Inventors: Jason Dallwig, David Hagen, Ching-Ying Cheung, Gerald Thomas, Stephen Yue
  • Xanthene dyes comprising a sulfonamide group
    Patent number: 8436170
    Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: May 7, 2013
    Assignee: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung
  • FLUORESCENT DYES, FLUORESCENT DYE KITS, AND METHODS OF PREPARING LABELED MOLECULES
    Publication number: 20120329068
    Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
    Type: Application
    Filed: March 16, 2012
    Publication date: December 27, 2012
    Applicant: Biotium, Inc.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Hye Eun Hoover