Patents by Inventor Ying Chih Chang

Ying Chih Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240141939
    Abstract: A chassis quick release device includes a housing including a base with a connected sliding channel and accommodating space therein and a cover assembled with the base, a locking block linearly movably set in the accommodating space, and an operating handle having a rod body positioned on the sliding channel and a grip assembled with the rod body. The rod body has a cylindrical joint that corresponds to the grip and has a shaft groove defined therein. The grip is provided with a sleeve corresponding to the cylindrical joint and defining therein an accommodating cavity. Moving the operating handle in the direction of the housing causes the locking block to slide out from the accommodating space to form a locked state. Pulling the operating handle away from the housing causes the locking block to move linearly in a second direction to form an unlocked state.
    Type: Application
    Filed: January 2, 2024
    Publication date: May 2, 2024
    Inventors: Ying-Chih TSENG, Ming-De WU, Ching-Kai CHANG
  • Publication number: 20240110139
    Abstract: A surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also, a cell culture system including a cell culture article having a surface coated with the surface coating. Also, methods of preparing the surface coatings and systems.
    Type: Application
    Filed: December 30, 2021
    Publication date: April 4, 2024
    Applicant: ACADEMIA SINICA
    Inventor: YING-CHIH CHANG
  • Publication number: 20240081017
    Abstract: A chassis quick release device includes a housing including a base provided with a sliding channel, a compression space, and accommodating space, a rotating space and a shaft in the rotating space and covered with a cover, a locking block linearly movably set in the accommodating space and providing a guide groove, a guide chamber, a receiving groove and an elastic member set in the receiving groove, a locking member having a shaft hole coupled to the shaft, a rotary reset member positioned on the shaft, resisting edge located at one end thereof that can rotate and protrude from the housing and a locking edge located at the other end thereof, and an operating handle including a rod body positioned in the sliding channel, the guide groove and the guide chamber and mounted with a grp and having a locking portion stopped against the guide chamber.
    Type: Application
    Filed: May 3, 2023
    Publication date: March 7, 2024
    Inventors: Ying-Chih TSENG, Ming-De WU, Ching-Kai CHANG
  • Publication number: 20240077968
    Abstract: An electronic device has sensors. More particularly, the electronic device is a small form factor electronic device such as earbuds, styluses, or electronic pencils, earphones, and so on. In some implementations, one or more touch sensors and one or more force sensors are coupled to a flexible circuit. In various implementations, the touch sensor and the force sensor are part of a single module controlled by a single controller. In a number of implementations, the flexible circuit is laminated to one or more portions of an interior surface of the electronic device.
    Type: Application
    Filed: August 30, 2023
    Publication date: March 7, 2024
    Inventors: Zhiyuan Sun, Wei Lin, Ying-da Wang, Chun-Chih Chang, Nathan K. Gupta, Travis N. Owens, Karan S. Jain, Supratik Datta, Kyle J. Campiotti
  • Publication number: 20230366879
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 16, 2023
    Inventors: Ying-Chih Chang, Han-Chung Wu, Po-Yuan Tseng, Jen-Chia Wu
  • Patent number: 11713441
    Abstract: The present disclosure provides methods of evaluating a therapeutic agent for cancer, and methods of cancer treatment.
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: August 1, 2023
    Assignee: Academia Sinica
    Inventor: Ying-Chih Chang
  • Patent number: 11674958
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 13, 2023
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Han-Chung Wu, Po-Yuan Tseng, Jen-Chia Wu
  • Publication number: 20230091341
    Abstract: The present disclosure provides methods of evaluating a therapeutic agent for cancer, and methods of cancer treatment.
    Type: Application
    Filed: September 30, 2022
    Publication date: March 23, 2023
    Applicant: Academia Sinica
    Inventor: Ying-Chih CHANG
  • Publication number: 20230036162
    Abstract: The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.
    Type: Application
    Filed: October 14, 2022
    Publication date: February 2, 2023
    Applicant: Academia Sinica
    Inventor: Ying-Chih CHANG
  • Patent number: 11492598
    Abstract: The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: November 8, 2022
    Assignee: ACADEMIA SINICA
    Inventor: Ying-Chih Chang
  • Publication number: 20220204943
    Abstract: The present disclosure provides a surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also provided is a cell culture system comprising a cell culture article having a surface coated with the surface coating. Uses and methods of preparing the surface coatings and systems are provided as well.
    Type: Application
    Filed: December 30, 2021
    Publication date: June 30, 2022
    Applicant: Academia Sinica
    Inventor: Ying-Chih CHANG
  • Publication number: 20220204944
    Abstract: The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.
    Type: Application
    Filed: December 30, 2021
    Publication date: June 30, 2022
    Applicant: Academia Sinica
    Inventor: Ying-Chih CHANG
  • Publication number: 20210088514
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Application
    Filed: March 27, 2020
    Publication date: March 25, 2021
    Inventors: Ying-Chih CHANG, Han-Chung WU, Po-Yuan TSENG, Jen-Chia WU
  • Patent number: 10495644
    Abstract: The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: December 3, 2019
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Jr-Ming Lai, Jen-Chia Wu, Huai-Lu Chen, Hung-Jen Shao
  • Patent number: 10112198
    Abstract: The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: October 30, 2018
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Jr-Ming Lai, Jen-Chia Wu
  • Publication number: 20170219593
    Abstract: The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.
    Type: Application
    Filed: April 1, 2015
    Publication date: August 3, 2017
    Applicant: ACADEMIA SINICA
    Inventor: Ying Chih CHANG
  • Publication number: 20170199184
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Application
    Filed: December 14, 2016
    Publication date: July 13, 2017
    Inventors: Ying-Chih CHANG, Han-Chung WU, Po-Yuan TSENG, Jen-Chia WU
  • Patent number: 9541480
    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: January 10, 2017
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Han-Chung Wu, Po-Yuan Tseng, Jen-Chia Wu
  • Patent number: 9494500
    Abstract: A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 15, 2016
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Chia-Hsien Hsu
  • Publication number: 20160059234
    Abstract: The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.
    Type: Application
    Filed: August 26, 2015
    Publication date: March 3, 2016
    Inventors: Ying-Chih Chang, Jr-Ming Lai, Jen-Chia Wu