Patents by Inventor Ying-Chih Pu

Ying-Chih Pu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11471940
    Abstract: Provided are methods of producing cobalt nanoparticles (Co NPs). The methods include combining a cobalt salt, a capping agent, and a reducing agent, under Co NP synthesis conditions including a temperature selected to produce cobalt nanoparticles of a pre-selected diameter, where the temperature and pre-selected diameter are inversely related. In certain aspects, the methods further include producing hollow gold nano spheres (HGNs) using the cobalt nanoparticles as scaffolds. Also provided are cobalt nanoparticles and hollow gold nano spheres (HGNs) produced according to the present methods. Kits that find use in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: October 18, 2022
    Assignee: The Regents of the University of California
    Inventors: Ying-Chih Pu, Frank Song, Weichun Zhang, Sarah Lindley, Staci Adams, Jin Zhang
  • Publication number: 20200114420
    Abstract: Provided are methods of producing cobalt nanoparticles (Co NPs). The methods include combining a cobalt salt, a capping agent, and a reducing agent, under Co NP synthesis conditions including a temperature selected to produce cobalt nanoparticles of a pre-selected diameter, where the temperature and pre-selected diameter are inversely related. In certain aspects, the methods further include producing hollow gold nano spheres (HGNs) using the cobalt nanoparticles as scaffolds. Also provided are cobalt nanoparticles and hollow gold nano spheres (HGNs) produced according to the present methods. Kits that find use in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: December 1, 2017
    Publication date: April 16, 2020
    Inventors: Ying-Chih Pu, Frank Song, Weichun Zhang, Sarah Lindley, Staci Adams, Jin Zhang
  • Patent number: 9995683
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: June 12, 2018
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 9777321
    Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 3, 2017
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Ying-Chih Pu, Chao-Chi Pan, Chih-Tsung Shih, Ming-Chia Li, Chein-Shiu Kuo, Hung-Chi Chien, Chang-Sheng Chu
  • Publication number: 20170009286
    Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
    Type: Application
    Filed: September 9, 2016
    Publication date: January 12, 2017
    Inventors: Chung-Fan Chiou, Ying-Chih Pu, Chao-Chi Pan, Chih-Tsung Shih, Ming-Chia Li, Chein-Shiu Kuo, Hung-Chi Chien, Chang-Sheng Chu
  • Patent number: 9482615
    Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: November 1, 2016
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Ying-Chih Pu, Chao-Chi Pan, Chih-Tsung Shih, Ming-Chia Li, Chein-Shiu Kuo, Hung-Chi Chien, Chang-Sheng Chu
  • Publication number: 20140367589
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 18, 2014
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8865077
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8865078
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8721969
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 13, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8368106
    Abstract: Method of manufacturing gradient composite material comprises steps of providing plural surface modified inorganic nanoparticles with functional groups or oligomers with functional groups; transferring the surface modified inorganic nanoparticles or oligomers with functional groups into an organic matrix to form a mixture; performing a photo polymerization step or a thermo-polymerization step for polymerizing and generating a gradient distribution of the surface modified inorganic nanoparticles or oligomers with functional groups in the mixture; and curing the mixture to solidify the organic matrix and form a structure with gradient composite, wherein the organic matrix is transferred into an organic polymer after curing.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: February 5, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Guang-Way Jang, Ying-Chih Pu, Yin-Ju Yang, Chang-Ming Wong, Chih-Fen Chang
  • Publication number: 20120112219
    Abstract: Method of manufacturing gradient composite material comprises steps of providing plural surface modified inorganic nanoparticles with functional groups or oligomers with functional groups; transferring the surface modified inorganic nanoparticles or oligomers with functional groups into an organic matrix to form a mixture; performing a photo polymerization step or a thermo-polymerization step for polymerizing and generating a gradient distribution of the surface modified inorganic nanoparticles or oligomers with functional groups in the mixture; and curing the mixture to solidify the organic matrix and form a structure with gradient composite, wherein the organic matrix is transferred into an organic polymer after curing.
    Type: Application
    Filed: November 4, 2010
    Publication date: May 10, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Guang-Way Jang, Ying-Chih Pu, Yin-Ju Yang, Chang-Ming Wong, Chih-Fen Chang
  • Publication number: 20110306039
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Application
    Filed: June 11, 2010
    Publication date: December 15, 2011
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Publication number: 20110306143
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Application
    Filed: July 29, 2010
    Publication date: December 15, 2011
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Publication number: 20110223590
    Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
    Type: Application
    Filed: March 11, 2011
    Publication date: September 15, 2011
    Applicant: Industrial Technology Research Institute
    Inventors: Chung-Fan CHIOU, Ying-Chih Pu, Chao-Chi Pan, Chih-Tsung Shih, Ming-Chia Li, Chein-Shiu Kuo, Hung-Chi Chien, Chang-Sheng Chu