Patents by Inventor Ying-Chu Shih

Ying-Chu Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12162820
    Abstract: The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: December 10, 2024
    Assignee: TAIWANJ PHARMACEUTICALS CO., LTD.
    Inventors: Syaulan S. Yang, Yan-feng Jiang, Meng-hsien Liu, Chia-hao Chang, Hao Shiuan Liu, Ying-chu Shih, Sheng Hung Liu, Chiung Wen Wang, Ting-ni Huang
  • Publication number: 20220153687
    Abstract: The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 19, 2022
    Applicant: TAIWANJ PHARMACEUTICALS CO., LTD.
    Inventors: Syaulan S. YANG, Yan-feng JIANG, Meng-hsien LIU, Chia-hao CHANG, Hao Shiuan LIU, Ying-chu SHIH, Sheng Hung LIU, Chiung Wen WANG, Ting-ni HUANG
  • Publication number: 20200352867
    Abstract: The present disclosure provides a sustained release formulation of opioid receptor antagonists comprising a sustained release granule comprising at least one of the opioid receptor antagonist, at least one of pharmaceutical acceptable carrier, and a pH-dependent polymer, wherein the sustained release granule is coated with the pH-dependent polymer, and the opioid receptor antagonist is selected from the group consisting of Nalmefene, Naltrexone, or a salt thereof.
    Type: Application
    Filed: February 1, 2019
    Publication date: November 12, 2020
    Applicant: TAIWANJ PHARMACEUTICALS CO., LTD.
    Inventors: Syaulan S. YANG, Eric Yueh-Lang SHEU, Ying-Chu SHIH
  • Publication number: 20180353520
    Abstract: The present invention provides a method of treating stroke or reducing nerve injury comprising administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) or formula (II) wherein W represents R1 represents R2 represents R3 represents R4 represents and R represent H or alkyl groups of C1-C6.
    Type: Application
    Filed: June 12, 2017
    Publication date: December 13, 2018
    Applicant: Arjil Biotech Holding Company Limited
    Inventors: Yeh B WU, Jir-Mehng LO, Ying Chu SHIH, Hui Ju LIANG
  • Publication number: 20180353521
    Abstract: The disclosure is related to a method for treating stroke or reducing nerve injury, which comprises administering to a subject in need thereof a therapeutically effective amount of a compound isolated and purified from Antrodia camphorata fruiting body by methanol extraction. In particular, the compound is dehydroeburicoic acid, dehydrosulphurenic acid or 4,7-Dimethoxy-5-methyl-1,3-benzodioxole.
    Type: Application
    Filed: June 12, 2018
    Publication date: December 13, 2018
    Applicant: Arjil Biotech Holding Company Limited
    Inventors: Yeh B WU, Jir-Mehng LO, Ying Chu SHIH, Hui Ju LIANG
  • Patent number: 10137159
    Abstract: A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained from a Boehmeria species. Also disclosed is a method for regenerating liver tissue and a method for improving a liver function.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: November 27, 2018
    Assignee: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Patent number: 9757372
    Abstract: The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to Toll-like receptor 4 (TLR4) antagonist compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of autoimmune liver diseases including but not limited to autoimmune hepatitis.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: September 12, 2017
    Assignee: TaiwanJ Pharmaceuticals Co., Ltd.
    Inventors: Peter J S Chiu, Mei-chi Hsu, Ying-Chu Shih, Edwin S C Wu
  • Patent number: 9549958
    Abstract: An extract of Cynanchum sp. in use of arthritis treatment is provided. The extract of Cynanchum sp. and an active ingredient contained therein, antofine, are applicable to a method, pharmaceutical composition and dietary supplement for treatment of arthritis. A mass production of antofine from plant extracts is also provided.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 24, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jennline Sheu, Lain-Tze Lee, Ying-Chu Shih, Cheng-Yu Lee, Yi-Ching Lee, Jir-Mehng Lo, Tien-Soung Tong, Jui-Hung Yen, Kuo-Kuei Huang, Ying-Fei Tsai
  • Publication number: 20160287578
    Abstract: The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to Toll-like receptor 4 (TLR4) antagonist compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of autoimmune liver diseases including but not limited to autoimmune hepatitis.
    Type: Application
    Filed: March 23, 2016
    Publication date: October 6, 2016
    Inventors: Peter JS CHIU, Mei-chi HSU, Ying-Chu SHIH, Edwin SC WU
  • Patent number: 9060989
    Abstract: A method for treating or relieving inflammatory bowel disease (IBD) is provided, including administering an extract of Bupleurum as an active ingredient to a subject. The Bupleurum may be selected from the group consisting of Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi and a combination thereof.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: June 23, 2015
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Nai-Yun Hu, Tien-Soung Tong
  • Patent number: 8969410
    Abstract: A pharmaceutical composition for alleviating or treating gout and the applications thereof are provided. The pharmaceutical composition includes p-coumaryl diacetate as an active ingredient.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 3, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Chu Shih, Jenn-Line Sheu, Cheng-Yu Lee, Jir-Mehng Lo, Yi-Ching Lee, Ying-Fei Tsai, Yi-Cheng Cheng
  • Publication number: 20140134280
    Abstract: An extract of Cynanchum sp. in use of arthritis treatment is provided. The extract of Cynanchum sp. and an active ingredient contained therein, antofine, are applicable to a method, pharmaceutical composition and dietary supplement for treatment of arthritis. A mass production of antofine from plant extracts is also provided.
    Type: Application
    Filed: April 27, 2012
    Publication date: May 15, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jennline Sheu, Lain-Tze Lee, Ying-Chu Shih, Cheng-Yu Lee, Yi-Ching Lee, Jir-Mehng Lo, Tien-Soung Tong, Jui-Hung Yen, Kuo-Kuei Huang, Ying-Fei Tsai
  • Publication number: 20140079818
    Abstract: A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained from a Boehmeria species. Also disclosed is a method for regenerating liver tissue and a method for improving a liver function.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Patent number: 8597693
    Abstract: A pharmaceutical composition with an immunomodulating function is provided, including an extract of Bupleurum obtained by grinding the Bupleurum, adding the ground Bupleurum to a solvent and isolating the extract from the solvent, wherein the Bupleurum comprises Bupleurum krlovianum, Bupleurum longiradiatum, Bupleurum smithii, Bupleurum pusillum, Bupleurum longicaule, Bupleurum salicifolium, Bupleurum scorzonerifolium and Bupleurums with at least one of the nucleotide sequences selected from a group consisting of SEQ ID NOs. 1˜6 and a nucleotide sequence with no more than 1% of the nucleotide sequence divergences of SEQ ID NOs. 1˜6, or combinations thereof.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: December 3, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Bie-Shung Tsai, Jir-Mehng Lo, Tien-Soung Tong, Jenn-Line Sheu, Kuo-Kuei Huang, Ying-Fei Tsai, Yi-Ching Lee, Hui-Ju Liang, Jui-Hung Yen, Cheng-Yu Lee
  • Patent number: 8501214
    Abstract: Disclosed herein is a hydrophilic foam. The hydrophilic foam includes a polyurethane matrix having a plurality of cells. The cells are capable of retaining water in an amount of least about 8 grams of water per gram of the hydrophilic foam.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: August 6, 2013
    Assignee: Modetex Biomedical Materials & Technology Industrial Corp.
    Inventors: Ming-Kuang Shih, Yu-Chou Chao, Jenn-Line Sheu, Ying-Chu Shih
  • Publication number: 20120164241
    Abstract: A pharmaceutical composition prepared from a Boehmeria species. This composition can be used to improve liver function and treat liver disease, and promoting liver tissue regeneration.
    Type: Application
    Filed: December 27, 2010
    Publication date: June 28, 2012
    Applicant: Industrial Technology Research Institute(ITRI)
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Publication number: 20120003250
    Abstract: A pharmaceutical composition with an immunomodulating function is provided, including an extract of Bupleurum obtained by grinding the Bupleurum, adding the ground Bupleurum to a solvent and isolating the extract from the solvent, wherein the Bupleurum comprises Bupleurum krlovianum, Bupleurum longiradiatum, Bupleurum smithii, Bupleurum pusillum, Bupleurum longicaule, Bupleurum salicifolium, Bupleurum scorzonerifolium and Bupleurums with at least one of the nucleotide sequences selected from a group consisting of SEQ ID NOs. 1˜6 and a nucleotide sequence with no more than 1% of the nucleotide sequence divergences of SEQ ID NOs. 1˜6, or combinations thereof.
    Type: Application
    Filed: July 1, 2010
    Publication date: January 5, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Bie-Shung Tsai, Jir-Mehng Lo, Tien-Soung Tong, Jenn-Line Sheu, Kuo-Kuei Huang, Ying-Fei Tsai, Yi-Ching Lee, Hui-Ju Liang, Jui-Hung Yen, Cheng-Yu Lee
  • Publication number: 20120003342
    Abstract: A pharmaceutical composition for treating or relieving inflammatory bowel disease (IBD) is provided. The pharmaceutical composition includes an extract of Bupleurum as an active ingredient, in which the Bupleurum is selected from the group consisting of Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi and a combination thereof.
    Type: Application
    Filed: May 28, 2011
    Publication date: January 5, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Nai-Yun Hu, Tien-Soung Tong
  • Patent number: 7714146
    Abstract: The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R1, R2 and R3 represents a moiety of formula (II), each of A1 and A2 independently is nitrogen, oxygen or sulfur, each of the others of R1, R2, R3, R1, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 is as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 11, 2010
    Assignee: Industrial Technology Research Institute
    Inventors: On Lee, Chrong-Shiong Hwang, Chih-Hung Chen, Yuan-Jang Tsai, Chih-Peng Liu, Ching-Huai Ko, Hsin-Hsin Shen, Ling-Mei Wang, Kuei-Tai Lai, Ying-Chu Shih, Ting-Shou Chen, Yen-Chun Chen, Lain-Tze Lee
  • Publication number: 20100104642
    Abstract: Disclosed herein is a hydrophilic foam. The hydrophilic foam includes a polyurethane matrix having a plurality of cells. The cells are capable of retaining water in an amount of least about 8 grams of water per gram of the hydrophilic foam.
    Type: Application
    Filed: December 31, 2009
    Publication date: April 29, 2010
    Inventors: Ming-Kuang Shih, Yu-Chou Chao, Jenn-Line Sheu, Ying-Chu Shih