Abstract: RhoA inhibitors that can covalently bind RhoA are described herein. The disclosed RhoA inhibitors show improved inhibitory efficacy (i.e., an IC50 value down to about 400 nM). Further, the disclosed RhoA inhibitors can specifically bind RhoA over other GTPases, such as other Ras GTPases (e.g., K-Ras and N-Ras) and particularly other Rho GTPases (e.g., Cdc42 and Rac1). The combination of high RhoA inhibitory efficacy and high RhoA specificity of the disclosed RhoA inhibitors allow these compounds to show high cytotoxicity and anti-metastatic effects in cancer cells, with negligible toxicity in normal cells, in vitro and in vivo. Pharmaceutical compositions containing the RhoA inhibitors and methods of using the RhoA inhibitors or pharmaceutical composition thereof for treating cancer are also described.

Abstract: A microbial fermentation method for improving tobacco quality, comprising the following steps: (1) inoculating flue-cured tobacco as an inoculation source into a tobacco powder medium, and cultivating at 20-40° C. for 20-50 h; (2) inoculating microbial liquid in step (1) into a fresh tobacco powder medium, cultivating at 20-40° C. for 20-50 h, and circulating for 15-25 cycles to obtain stable flue-cured tobacco microbial flora; (3) inoculating the microbial flora obtained in step (2) into the fresh tobacco powder medium, and culturing at 20-40° C. for 20-50 h to obtain seed liquid of the microbial flora; (4) centrifuging the microbial liquid obtained in step (3) and collecting microbes; (5) washing the microbes collected in step (4); (6) resuspending the washed bacteria in step (5) to obtain a microbial suspension; and (7) spraying the microbial suspension in step (6) to the tobacco leaves for fermentation for 6-8 days.

Abstract: The present invention relates to an assistive glove for daily activities of stroke patient which comprises a main body, a first pulling member, a second pulling member, and plural circular strings. The main body comprises a thumb sleeve, at least one finger sleeve a palm portion connected to the thumb sleeve and the at least one finger sleeve by one side and a wrist portion connected to another side of the palm portion. The first pulling member and the second pulling member are disposed on the palm portion and having a first hook and at least one second hook corresponding to the thumb sleeve and the at least one finger sleeve. The plural circular strings are hung on the first hook and the at least one second hook and fixed to the thumb sleeve and the at least one finger sleeve respectively.

Abstract: The present invention relates to an assistive glove for daily activities of stroke patient which comprises a main body, a first pulling member, a second pulling member, and plural circular strings. The main body comprises a thumb sleeve, at least one finger sleeve a palm portion connected to the thumb sleeve and the at least one finger sleeve by one side and a wrist portion connected to another side of the palm portion. The first pulling member and the second pulling member are disposed on the palm portion and having a first hook and at least one second hook corresponding to the thumb sleeve and the at least one finger sleeve. The plural circular strings are hung on the first hook and the at least one second hook and fixed to the thumb sleeve and the at least one finger sleeve respectively.

Abstract: A wind turbine blade is described, which extends in a spanwise direction from a root end to a tip end and defines an aerodynamic airfoil cross-section between a leading edge and a trailing edge in a chordwise direction transverse to the spanwise direction. The blade has a camber in the chordwise direction and includes a blade body and a moveable flap. The flap is moveable relative to the blade body to vary the camber of the blade. A deformable panel is located between the blade body and the moveable flap. The panel has an undulating profile comprising an alternating succession of ridges and troughs, which each extend in a first direction. The panel is formed of a material having anisotropic intrinsic stiffness with maximum anisotropic intrinsic stiffness being transverse to the first direction. In a preferred embodiment, the deformable panel is corrugated.

Abstract: A feeding bottle includes a bottle body, a retaining member, a sucking component and a nipple. The bottle defines an opening, the retaining member has a bowl portion and a barrel portion, the bowl forms peripheral flange. The sucking component includes a tube and a sucking head, the nipple includes a latching section having resisting flange. The bottle body, the retaining member, the sucking component, and the nipple are made of silicon material, the retaining member engages into the bottle body, the tube and the sucking head are received in the bottle body, the bowl portion is received in the open, and the peripheral flange abuts on the top of the open. The nipple engages with the retaining member, the latching section fits with the barrel portion, and the resisting flange abuts on the peripheral flange.

Abstract: A wind turbine blade is described, which extends in a spanwise direction from a root end to a tip end and defines an aerodynamic airfoil cross-section between a leading edge and a trailing edge in a chordwise direction transverse to the spanwise direction. The blade has a camber in the chordwise direction and includes a blade body and a moveable flap. The flap is moveable relative to the blade body to vary the camber of the blade. A deformable panel is located between the blade body and the moveable flap. The panel has an undulating profile comprising an alternating succession of ridges and troughs, which each extend in a first direction. The panel is formed of a material having anisotropic intrinsic stiffness with maximum anisotropic intrinsic stiffness being transverse to the first direction. In a preferred embodiment, the deformable panel is corrugated.