Patents by Inventor Ying-Ta Lai
Ying-Ta Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11878301Abstract: An analysis cartridge includes a first cover, a second cover, a plurality of containers, a plurality of fluid tunnels and a rotary valve. The second cover has two opposite surfaces, a plurality of first through holes and a second through hole individually penetrate through the two opposite surfaces, and the first cover is attached to the second cover. The plurality of containers are disposed between the first cover and the second cover, with each of the containers being aligned to and filled in the first through holes. The plurality of the fluid tunnels are disposed on the first cover, and each of which is individually connected with a first pipette. The rotary valve is rotatably disposed between the first cover and the second cover to correspond to the second through hole, and a flow channel disposed on the rotary valve is connected with the containers individually.Type: GrantFiled: December 8, 2021Date of Patent: January 23, 2024Assignee: Credo Diagnostics Biomedical Pte. Ltd.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Jim-Yi Liao, Shu-Hong Huang, Fan-Yun Huang, Ruei-Yi Tsai, Li-Yu Hsiung
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Patent number: 11680291Abstract: The present invention discloses a Polymerase Chain Reaction (PCR) apparatus for real-time detecting of one or more fluorescent signals. According to the apparatus, the PCR is performed by controlling heating and cooling intervals of a reagent container receiving space. With the aid of an added specific probe and fluorescent material, as well as a light source and a spectrometer, a generated fluorescent signal is detected. Meanwhile, the apparatus is also pre-loaded with an algorithm configured to analyze and quantify the fluorescent signal in a real-time manner.Type: GrantFiled: March 12, 2020Date of Patent: June 20, 2023Assignee: CREDO DIAGNOSTICS BIOMEDICAL PTE, LTD.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Chun-Te Wu, Yu-Wen Huang, Han-Yi Chen
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Patent number: 11624641Abstract: What is disclosed in the present invention is to provide a quantitative transfer pipette structure, wherein an anti-backflow compartment is configured in the first bulb. The dimensions and locations of the first bulb, the second bulb and the third bulb are specifically configured to aspirate and transfer a specific volume of the liquid to a container, mix the liquid with the substance in the container by pressing and releasing the specific bulbs, so as to achieve the effects of precise quantification and sufficient mixing.Type: GrantFiled: August 3, 2020Date of Patent: April 11, 2023Assignee: Credo Diagnostics Biomedical Pte. Ltd.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Jim-Yi Liao, Fan-Yun Huang, Yi-Hsi Chen
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Patent number: 11565268Abstract: The present invention discloses a convective PCR apparatus by using a transparent conductive thin film to replace the traditional metal heater. The PCR reaction is activated when the container with reagents contacted the heated transparent conductive thin film and the temperature inside the container raised to initiate the convective circulation. Also, the present invention could apply for a quantitative PCR reaction by adding a specific probe, a fluorescent dye, a light source, or a photon receiver.Type: GrantFiled: December 16, 2018Date of Patent: January 31, 2023Assignee: Credo Diagnostics Biomedical Pte. Ltd.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Ming-Lung Hung, Cheng-Yueh Chung, Han-Yi Chen
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Publication number: 20220388000Abstract: An analysis cartridge includes a first cover, a second cover, a plurality of containers, a plurality of fluid tunnels and a rotary valve. The second cover has two opposite surfaces, a plurality of first through holes and a second through hole individually penetrate through the two opposite surfaces, and the first cover is attached to the second cover. The plurality of containers are disposed between the first cover and the second cover, with each of the containers being aligned to and filled in the first through holes. The plurality of the fluid tunnels are disposed on the first cover, and each of which is individually connected with a first pipette. The rotary valve is rotatably disposed between the first cover and the second cover to correspond to the second through hole, and a flow channel disposed on the rotary valve is connected with the containers individually.Type: ApplicationFiled: December 8, 2021Publication date: December 8, 2022Applicant: Credo Diagnostics Biomedical Pte. Ltd.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Jim-Yi Liao, Shu-Hong Huang, Fan-Yun Huang, Ruei-Yi Tsai, Li-Yu Hsiung
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Publication number: 20220389402Abstract: The present disclosure relates to a method and an apparatus for opening the external layer structure of cells using laser, wherein the short pulse laser excited from a laser diode is collimated via the optical lens and concentrated at a focus, a biological sample which is fixed on the focus or moves through the focus is treated with the concentrated short pulse laser, so that the cell membrane or cell wall of cells in the sample is broken.Type: ApplicationFiled: June 30, 2021Publication date: December 8, 2022Applicant: Credo Diagnostics Biomedical Pte. Ltd.Inventors: Ying-Ta Lai, Yu-Cheng Ou, Yi-Hsi Chen, Chung-Wei Tsai, Kuan-Ying Chen, Ruei-Yi Tsai, Chih-Yuan Chen
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Publication number: 20220003586Abstract: What is disclosed in the present invention is to provide a quantitative transfer pipette structure, wherein an anti-backflow compartment is configured in the first bulb. The dimensions and locations of the first bulb, the second bulb and the third bulb are specifically configured to aspirate and transfer a specific volume of the liquid to a container, mix the liquid with the substance in the container by pressing and releasing the specific bulbs, so as to achieve the effects of precise quantification and sufficient mixing.Type: ApplicationFiled: August 3, 2020Publication date: January 6, 2022Inventors: Ying-Ta Lai, Yu-Cheng Ou, Jim-Yi Liao, Fan-Yun Huang, Yi-Hsi Chen
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Publication number: 20210394176Abstract: The present invention provides a sample tube for polymerase chain reaction. The sample tube includes a sample tube body having an annular side wall and a bottom wall connected to annular side wall, wherein the annular side wall and the bottom wall form an accommodating space for accommodating a reaction mixture; and a first extension member extending from the bottom wall to the accommodating space, wherein, to carry out PCR, the reaction mixture immerses the first extension member, such that the light from the light source enters into the reaction mixture via the bottom and the bottom wall of the sample tube and the first extension member sequentially.Type: ApplicationFiled: August 18, 2020Publication date: December 23, 2021Inventors: Ying-Ta Lai, Yu-Cheng Ou, Jim-Yi Liao, Yi-Hsi Chen
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Publication number: 20210043277Abstract: An analytical method includes obtaining a first data and performing curve fitting on the first data according to at least one basis to generate at least one coefficient corresponding to the at least one basis. A function pattern corresponding to one of the at least one basis has asymmetry.Type: ApplicationFiled: January 30, 2020Publication date: February 11, 2021Inventors: Ying-Ta Lai, Yu-Cheng Ou, Yi-Hsi Chen, Kuan-Ying Chen, Hsi-Yuan Chen, Yu-Yu Liu
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Publication number: 20200392559Abstract: The present invention discloses a Polymerase Chain Reaction (PCR) apparatus for real-time detecting of one or more fluorescent signals. According to the apparatus, the PCR is performed by controlling heating and cooling intervals of a reagent container receiving space. With the aid of an added specific probe and fluorescent material, as well as a light source and a spectrometer, a generated fluorescent signal is detected. Meanwhile, the apparatus is also pre-loaded with an algorithm configured to analyze and quantify the fluorescent signal in a real-time manner.Type: ApplicationFiled: March 12, 2020Publication date: December 17, 2020Applicant: CREDO DIAGNOSTICS BIOMEDICAL PTE. LTD.Inventors: YING-TA LAI, YU-CHENG OU, CHUN-TE WU, YU-WEN HUANG, HAN-YI CHEN
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Patent number: 10510436Abstract: The present invention discloses a method of real-time quantification of a target nucleic acid in a sample by constructing a reference table of copy number vs. designated parameter from reference samples which sharing the same nucleic acid sequences with the target nucleic acid. The method includes (a) constructing a reference table of copy number vs. designated parameter from reference samples; (b) amplifying the target nucleic acid; (c) monitoring and detecting the amplification of the target nucleic acid in real-time; (d) analyzing the detected signals to get the designated parameter of the target nucleic acid; and (e) looking up and interpolating to the reference table to get the copy number of the target nucleic acid.Type: GrantFiled: July 5, 2016Date of Patent: December 17, 2019Assignee: Credo Biomedical Pte Ltd.Inventors: Jr. Winston Wong, Stephen Chang-Chi Kao, Ying-Ta Lai, Yih-Jyh Shann, Ming-Fa Chen, Chih-Rong Chen
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Publication number: 20190193080Abstract: The present invention discloses a convective PCR apparatus by using a transparent conductive thin film to replace the traditional metal heater. The PCR reaction is activated when the container with reagents contacted the heated transparent conductive thin film and the temperature inside the container raised to initiate the convective circulation. Also, the present invention could apply for a quantitative PCR reaction by adding a specific probe, fluorescent dye, light source, or photon receiver.Type: ApplicationFiled: December 16, 2018Publication date: June 27, 2019Inventors: Ying-Ta Lai, Yu-Cheng Ou, Ming-Lung Hung, Cheng-Yueh Chung, Han-Yi Chen
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Patent number: 10233509Abstract: The present invention disclose a method for detection CPV 2a, 2b, and 2c in a sample by detecting VP2 gene. The signals can be detected by both fluorescent detection system and lateral flow immunochromatographic assay. The second object of this present invention is to provide a method to discriminate the wild type from the vaccine type. The first approach to achieve this object is discriminating wild type from vaccine type by SNP 36, which could be used on both fluorescent detection system and lateral flow immunochromatographic assay. The second approach to achieve this object is discriminating wild type from vaccine type by SNP 899 and SNP 963.Type: GrantFiled: December 7, 2016Date of Patent: March 19, 2019Assignee: Credo Biomedical Pte Ltd.Inventors: Jr Winston Wong, Stephen Chang-Chi Kao, Ying-Ta Lai, Ming-Lung Hung, Wei-Chen Wang
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Patent number: 10222307Abstract: A mixing device for operating biological, chemical or biochemical materials used in an assay includes a mixing member formed with a plurality of chambers, each having a sealable port provided along an edge of the mixing member. The mixing device also includes one or more compartments that are movable along the edge of the mixing member between selected ones of the sealed chambers. This compartment is operable to receive materials from and transfer materials between the chambers. Selected ones of the chambers include associated processing elements, for example, including heating and cooling elements, magnetic elements, membranes and lateral flow devices. The mixing device is also pivotable, for example, to facilitate the application of gravity force in the transfer of materials between the chambers and one or more compartments. The mixing device may operate manually by hand-held unit. Also, this mixing device may operate automatically with at least one driving unit.Type: GrantFiled: May 4, 2017Date of Patent: March 5, 2019Assignee: Credo Biomedical Pte Ltd.Inventors: Jr Winston Wong, Stephen Chang-Chi Kao, Ying-Ta Lai, Ming-Fa Chen, Sheng-Pin Hsiao
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Publication number: 20180155797Abstract: The present invention disclose a method for detection CPV 2a, 2b, and 2c in a sample by detecting VP2 gene. The signals can be detected by both fluorescent detection system and lateral flow immunochromatographic assay. The second object of this present invention is to provide a method to discriminate the wild type from the vaccine type. The first approach to achieve this object is discriminating wild type from vaccine type by SNP 36, which could be used on both fluorescent detection system and lateral flow immunochromatographic assay. The second approach to achieve this object is discriminating wild type from vaccine type by SNP 899 and SNP 963.Type: ApplicationFiled: December 7, 2016Publication date: June 7, 2018Inventors: Jr Winston WONG, Stephen, Chang-Chi KAO, Ying-Ta Lai, Ming-Lung Hung, Wei-Chen Wang
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Patent number: 9873910Abstract: The present invention provides a method of using a two-stage nucleic acid reaction and detection tube. First, a reaction and detection tube is provided. Then a reaction is performed by using a liquid in the storing space of the second tube, following by putting the dipstick into the dipstick fixing space of the connector. The first tube, the second tube and the connector is assembled together, wherein the dipstick is placed both in the dipstick fixing space of the connector and the detection space of the first tube. The reaction and detection tube is rotated from bottom to top, thus making the liquid in the storing space of the second tube flow into the liquid collection space through the diversion unit and then contact the dipstick in the dipstick fixing space. A detection result is then observed from the dipstick.Type: GrantFiled: October 12, 2017Date of Patent: January 23, 2018Assignee: Credo Biomedical Pte Ltd.Inventors: Jr Winston Wong, Stephen Chang-Chi Kao, Ying-Ta Lai, Ming-Fa Chen
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Publication number: 20180011967Abstract: The present invention discloses a method of real-time quantification of a target nucleic acid in a sample by constructing a reference table of copy number vs. designated parameter from reference samples which sharing the same nucleic acid sequences with the target nucleic acid. After that, obtain the designated parameter of the target sample and get the copy number by looking up and interpolating to the reference table. The object of the present invention is in particular provide methods for the quantification of the target nucleic acid which the target nucleic acid is quantified independently without comparing it to the standard controls by using a calibration curve. This invention will not only provide a new quantifying method, but will also propose a new standard operational method that eliminates the variations accompanying amplification efficiency, polymerase activity, primer concentrations, and instrument variations.Type: ApplicationFiled: July 5, 2016Publication date: January 11, 2018Inventors: Jr Winston WONG, Stephen, Chang-Chi KAO, Ying-Ta Lai, Yih-Jyh Shann, Ming-Fa Chen, Chih-Rong Chen
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Publication number: 20170336304Abstract: A mixing device for operating biological, chemical or biochemical materials used in an assay includes a mixing member formed with a plurality of chambers, each having a sealable port provided along an edge of the mixing member. The mixing device also includes one or more compartments that are movable along the edge of the mixing member between selected ones of the sealed chambers. This compartment is operable to receive materials from and transfer materials between the chambers. Selected ones of the chambers include associated processing elements, for example, including heating and cooling elements, magnetic elements, membranes and lateral flow devices. The mixing device is also pivotable, for example, to facilitate the application of gravity force in the transfer of materials between the chambers and one or more compartments. The mixing device may operate manually by hand-held unit. Also, this mixing device may operate automatically with at least one driving unit.Type: ApplicationFiled: May 4, 2017Publication date: November 23, 2017Inventors: Jr Winston WONG, Stephen, Chang-Chi KAO, Ying-Ta Lai, Ming-Fa Chen, Sheng-Pin Hsiao
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Patent number: 9816136Abstract: The present invention discloses a two-stage reaction and detection tube comprises a first tube, a second tube and a connector. The first tube comprises a detection space for placing a dipstick and a detection space for the test result. The second tube comprises a storing space for the PCR or RT-PCR reagents and the target gene segments. The connector comprises a first portion and a second portion which connect to the first tube and the second tube respectively. The connector further comprises a diversion unit, a liquid collection space, and a dipstick fixing space, where the liquid collection space is connected to the dipstick fixing space. The target gene amplification and detection could be directly processed in the same tube without any liquid transfer.Type: GrantFiled: June 6, 2017Date of Patent: November 14, 2017Assignee: Credo Biomedical Pte Ltd.Inventors: Jr Winston Wong, Stephen Chang-Chi Kao, Ying-Ta Lai, Ming-Fa Chen
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Publication number: 20170282178Abstract: The present invention is related to a portable apparatus for performing uni-directional convective qPCR or qRT-PCR in a mixing reagent containing a target nucleic acid and a fluorescence dye including denaturation, annealing and extension processes. The apparatus includes at least a temperature controlling unit which comprises at least one heat source and one temperature sensor, a circulation-enabling container, a light source, a photo-detector, a filter, a set of optical elements, and a processor.Type: ApplicationFiled: March 28, 2017Publication date: October 5, 2017Inventors: Jr Winston WONG, Stephen, Chang-Chi KAO, Ying-Ta Lai, Ming-Fa Chen, Chih-Rong Chen