Abstract: A method for treating Wilson's disease with tetradentate copper chelators therapy is provided. Specific copper chelators of the TDMQ tetradentate series are highly efficient for the treatment of Wilson's disease murine model. The concentration of copper in liver of “toxic milk” TX mice decreased and the fecal excretion of copper increased with the treatment with TDMQ20. Both effects are dose-dependent. Pharmacological data obtained on this TX mouse model with TDMQ20 strongly support the selection of this type of ligand as drug-candidate for this genetic disease.

Abstract: An extended ratchet wrench includes a body, a tool head, and a fixing ring. The body has a head. The head has a first positioning surface, a first positioning structure, and an outer threaded portion that are concentric. The tool head has a rod body. The rod body has an engaging base and a support portion of a free end of the rod body is provided with a driven head assembly. The engaging base has a second positioning structure and a second positioning surface in contact with the first positioning surface. The first positioning structure matches with the second positioning structure in a convex-concave manner at any one of a plurality of angles with the axis as a rotation center. An inner side of the fixing ring has an inner threaded portion screwed with an outer threaded portion and a hooking surface hooking the engaging base in a second direction.

Abstract: A delivery system for delivering a vaporized source precursor in ion implantation, including: an assembly including: a vessel having an interior volume and configured to produce the vaporized source precursor; a first heater to heat the vessel; and a manifold configured to control the output of the vaporized source precursor to an ion implantation device, wherein the assembly is configured to be disposed upstream of the source inlet flange.

Abstract: The present invention provides compounds and methods targeting human lymphotactins, including therapeutic antibodies, pharmaceutical compositions and methods of use thereof, useful in the field of immune-mediated diseases including ulcerative colitis, vitiligo, multiple sclerosis, alopecia areata, psoriasis, type 1 diabetes, and asthma.

Abstract: An ion implantation system and related methods are provided herein. An ion implantation system comprises a gas supply assembly comprising at least one gas supply vessel in fluid communication with an arc chamber. The gas supply assembly is configured to supply a gas component comprising at least one of GeF4, GeH4, H2, a fluorine-containing gas, or any combination thereof. When the gas component is supplied from the at least one gas supply vessel to the arc chamber for implantation into a substrate, a beam current of Ge ions generated from the gas component is greater than a beam current of Ge ions generated from a control gas component.

Abstract: A display panel and an operation method of the display panel are provided. The display panel includes a display area and a frame area. The display area is configured to display an image. During a touch sensing period, the display area and the frame area emit an uplink signal to perform an active stylus touch detection operation.

Abstract: A touch panel includes a first substrate, a second substrate, a display material layer and a cover layer. A plurality of thin-film transistors (TFTs) of a plurality of pixels are deployed on the first substrate, wherein the plurality of pixels have a plurality of source lines and a plurality of gate lines. A common electrode is deployed on a second substrate. The display material layer is deployed between the first substrate and the second substrate. The cover layer is capable of being contacted by a touch object. The first substrate is located between the cover layer and the second substrate. At least one line of the plurality of source lines and the plurality of gate lines forms at least one touch sensing electrode.

Abstract: The subject matter disclosed herein is generally directed to stratifying and treating coronavirus infections based on intrinsic immune states.

Abstract: A biological sample pretreatment device includes a base body and a moveable part. The base body is formed with an elongated accommodation space configured to accommodate a sampling tube and a reaction tube aligned with each other. The moveable part moveably connects to the base body for ejecting the reaction tube from the base body.

Abstract: Introduced here is an approach to further refining a set of locations that can serve as inputs to a machine learning algorithm. These locations may refer to unique molecular positions in a reference human genome and/or unique mutations thereof that are relevant in diagnosing cancer. A computing system can determine the diagnostic relevance of each location and then discard some of the less diagnostically relevant locations.

Abstract: The present disclosure provides human CD33 antibodies and antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of myeloid cell associated diseases.

Abstract: The subject matter disclosed herein is generally directed to stratifying and treating coronavirus infections based on intrinsic immune states.

Abstract: Described are ion implantation devices, systems, and methods, and in particular to an ion source that is useful for generating an aluminum ion beam.

Abstract: Introduced here is an approach to further refining an initial set of target locations that can serve as inputs to machine learning mechanisms. These target locations may refer to unique molecular positions in a reference human genome and/or mutations thereof that are diagnostically relevant for a given cancer type. The system can implement a refinement mechanism to account for unnecessary or problematic data, such as consecutive/overlapping patterns, non-uniform read counts, insufficient data quality, internal processing noises, and/or insufficient data counts.

Abstract: A system and method for generating aluminum ions for implantation into a substrate. The system and method comprise flowing a chlorine-containing gas from a first vessel, optionally with a hydrogen-containing co-gas and optionally with a fluorine-containing co-gas, to an ion source chamber of an ion implantation device. The ion source chamber comprises a solid aluminum target material. At the ion source chamber, aluminum ions are generated for implantation into a substrate.

Abstract: An in-cell optical sensing display panel includes a pixel array, a plurality of first optical sensors and a plurality of second optical sensors. The pixel array is disposed in an active area of the in-cell optical sensing display panel, and the active area includes a first region and a second region which surrounds the first region. The sensor array is disposed in the first region of the active area and is configured to sense a fingerprint of a finger touching a surface of the in-cell optical sensing display panel. The second optical sensors are disposed in the second region of the active area and are configured to sense ambient light, and the second optical sensors are not to be used for fingerprint sensing.

Abstract: The present disclosure relates to an ion implantation tool source and gas delivery system. The system can include a gas source comprising one or more gas supply vessels, an ion implanter arc chamber connected to the gas source, and a gallium target contained within the ion implanter arc chamber. The one or more gas supply vessels can supply a mixture of gases of hydrogen and fluoride. The hydrogen can be from 5% to 60% of the mixture of gases.

Abstract: Described are ion implantation devices, systems, and methods, and in particular to an ion source that is useful for generating an aluminum ion beam.

Abstract: A method for in-situ non-contact detection of a symmetry error of a keyway located on the shaft-type workpiece includes the following steps: establishing a detection system and a system calculation coordinate system; controlling rotation of a shaft-type workpiece, continuously acquiring data of a detection part by means of a laser displacement sensor, and calculating and analyzing the acquired data to obtain a symmetry error of a detection section; and moving the laser displacement sensor in an axis direction, and calculating symmetry errors of a plurality of sections of the keyway, to obtain a symmetry error of the keyway located on the shaft-type workpiece.