Patents by Inventor Ying Wan

Ying Wan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210310010
    Abstract: A plasmid vector for expressing mRNA in vitro, a construction method and an application thereof are provided. The plasmid vector includes a poly(adenyl deoxyribonucleotide) (poly(dA)) fragment formed by more than 30 adenyl deoxyribonucleotides at the 3?-end tail of a gene to be inserted for expression. The plasmid vector for expressing mRNA in vitro in the present invention can express a target protein gene and a poly(A) formed by 60 adenyl ribonucleotides, and the expressed mRNA directly possesses the poly(A) without additional tailing operation. In addition, the mRNA transcribed in vitro shows stronger mRNA stability and higher protein expression ability after being transfected into cells.
    Type: Application
    Filed: September 3, 2020
    Publication date: October 7, 2021
    Applicant: Shenzhen NeoCura Biotechnology Corporation
    Inventors: Youdong PAN, Qi SONG, An XIAO, Yi WANG, Ji WAN, Gang LIU, Ying WEN
  • Publication number: 20210299058
    Abstract: A delivery system for mRNA nucleic acid drugs, a preparation method and an application thereof are provided. The delivery system includes lipid nanoparticles for loading one or more kinds of mRNA molecules, wherein the lipid nanoparticles are prepared from raw materials including an ionizable cationic lipid, a phospholipid auxiliary lipid, cholesterol, and a polyethylene glycol-derivatized phospholipid. In the mRNA nucleic acid drug targeted intracellular delivery system based on the non-viral carrier of the present invention, the mRNA is concentrated and loaded by the electrostatic interaction between the ionizable cationic lipid and the mRNA. Phospholipid auxiliary lipid component-mediated pH sensitivity and late endosomal escape enable mRNA nucleic acid drugs to be efficiently delivered to target cells and then released into the cytoplasm of the target cells for exerting a pharmacodynamic effect.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 30, 2021
    Applicant: Shenzhen Neocura Biotechnology Corporation
    Inventors: Youdong PAN, Gang LIU, Yi WANG, An XIAO, Ji WAN, Ying WEN, Qi SONG
  • Patent number: 10923686
    Abstract: A heat dissipation structure for a flexible display is disclosed, and includes: a substrate, an anode metal layer, light emitting diode elements, a pixel defining layer, a cathode metal layer, and a heat conducting insulator disposed in sequence. The pixel defining layer has grooves, and the heat conducting insulator is sandwiched between the anode metal layer and the cathode metal layer, and disposed in the grooves. The heat conducting insulator is used to connect the anode metal layer and the cathode metal layer, so as to form an electrically insulating and thermally conducting path between the anode metal layer and the cathode metal layer.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: February 16, 2021
    Assignee: Wuhan China Star Optoelectronics Semiconductor Display Technology Co., Ltd.
    Inventors: Ying Wan, Sheng Liu
  • Publication number: 20200203655
    Abstract: A heat dissipation structure for a flexible display is disclosed, and includes: a substrate, an anode metal layer, light emitting diode elements, a pixel defining layer, a cathode metal layer, and a heat conducting insulator disposed in sequence. The pixel defining layer has grooves, and the heat conducting insulator is sandwiched between the anode metal layer and the cathode metal layer, and disposed in the grooves. The heat conducting insulator is used to connect the anode metal layer and the cathode metal layer, so as to form an electrically insulating and thermally conducting path between the anode metal layer and the cathode metal layer.
    Type: Application
    Filed: January 17, 2019
    Publication date: June 25, 2020
    Inventors: Ying WAN, Sheng LIU
  • Publication number: 20200132647
    Abstract: Disclosed are a device and a method for determining the solubility of elemental sulfur in a sulfur-containing gas. The device includes a displacement pump, a first sampler, a high-temperature box, a back-pressure pump, a control valve, an adsorption tank, a low-temperature box, a flow meter and a collection tank. An outlet of the displacement pump is in communication with an inlet of the first sampler; an outlet of the first sampler is in communication with a first inlet of the control valve; a second inlet of the control valve is in communication with an outlet of the back-pressure pump; an outlet of the control valve is in communication with a first opening of the adsorption tank; a second opening of the adsorption tank is in communication with the flow meter; and a third opening of the adsorption tank is in communication with the collection tank.
    Type: Application
    Filed: May 25, 2018
    Publication date: April 30, 2020
    Applicants: PETROCHINA COMPANY LIMITED, SICHUAN KELITE OIL AND GAS TECHNOLOGY CO. LTD.
    Inventors: Li WANG, Zhao DING, Fusen XIAO, Dihong ZHANG, Daqing TANG, Jingyuan CHEN, Ying WAN, Xuefeng YANG, Bo KONG, Tong LIU, Banghua XIE, Hua ZHOU, Zhijin PU
  • Publication number: 20190126268
    Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.
    Type: Application
    Filed: October 29, 2018
    Publication date: May 2, 2019
    Inventors: Pak Kin Kin WONG, Tak-Sing WONG, Jing WANG, Hui LI, Yi LU, Ying WAN
  • Publication number: 20160120805
    Abstract: Provided are methods of treating a subject with a composition comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom. Also provided are methods of promoting dentinogenesis, amelogenesis, or osteogenesis. Also provided are compositions comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 5, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jeremy J. Mao, Ying Wan, Nan Jiang, Mo Chen
  • Publication number: 20140057841
    Abstract: Disclosed is a recombinant human insulin or analog conjugate thereof. Said conjugate is formed by connecting the ?-amino group of lysine 29 of the B chain to activated polyethylene glycol by means of an amide bond. Further disclosed is a method of preparing said conjugate, a pharmaceutical compound, and a use for said conjugate in preparing medication for treating Type 1 and Type 2 diabetes.
    Type: Application
    Filed: March 19, 2012
    Publication date: February 27, 2014
    Applicant: Chongqing Fagen Biomedical Inc.
    Inventors: Kai Fan, Yu Cao, Yong Chen, Hongliang Li, Hairong Chen, Ying Wan