Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.

Abstract: The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6.

Abstract: Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of B cells and/or T cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflammatory diseases. Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein.

Abstract: Provided herein are methods of using compounds and compositions for treating, managing, and/or preventing systemic lupus erythematosus (SLE). Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein.

Abstract: Antimicrobial ophthalmic devices such as contact lenses, ocular inserts, ocular bandages, and intraocular lenses comprise a hydrogel and an antimicrobially-effective amount of epsilon polylysine non-covalently attached to the hydrogel.

Abstract: Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

Abstract: The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6.

Abstract: A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Abstract: The present invention provides a two-step Gram staining method. The method is conducted by using a clean slide, followed by adding 10˜30 ?l primary stain from a reagent kit, adding an equivalent amount of specimens uniformly on said slide, then immediately adding 30˜60 ?l counter-stain on said slide for incubating 15 seconds, rinsing with water, and finally examining under a microscope, the result appears color contrast on the center of the slide between the Gram-negative bacteria performing light red color and the Gram-positive bacteria performing deep purple color.

Abstract: An electric heating sole comprises a sole main body (1). A heating layer (2) and a press type electric generator (3) are arranged in the sole main body (1). Heating elements are distributed in the heating layer (2). The heating layer (2) is connected with the press type electric generator (3). An intensive area (21) is arranged on the heating layer (2); the distribution density of the heating elements in the intensive area (21) is higher than that of the heating elements at other area of the heating layer (2); and the intensive area (21) is arranged at a position where the heating layer (2) corresponds to acupuncture points on the foot of a human body.

Abstract: A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Abstract: A speaker assembly includes a base including two receiving holes, a cover mounted on a first surface the base, a speaker, a flexible printed circuit (FPC) attached to a second surface the base opposite to the first surface, and two springs received in the receiving holes. The cover includes a receiving space to receive the speaker. The speaker includes two first pads. The FPC includes two second pads. The springs electrically connect the first pads to the second pads.

Abstract: A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Abstract: An architecture by which combined scheduling and network coding can be used in mesh networks, and more particularly wireless mesh networks. In various embodiments, this architecture includes a scheduling MAC protocol for scheduling nodes in the mesh network in order to take advantage of network coding opportunities. The schedule takes advantage of these opportunities by assigning a gain to transmit packets based upon the number of packets that are transmitted concurrently and choosing a schedule which minimizes the gain over the scheduling horizon. Regarding the assigned gain, in one embodiment this value is one for basic non-encoded operations and two or more for encoded operations. A scheduling MAC protocol is also used to announce and arbitrate network coding opportunities by indicating which packets (as characterized by their transmission slot) are to be encoded with each other.

Abstract: A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

Abstract: A speaker assembly includes a base including two receiving holes, a cover mounted on a first surface the base, a speaker, a flexible printed circuit (FPC) attached to a second surface the base opposite to the first surface, and two springs received in the receiving holes. The cover includes a receiving space to receive the speaker. The speaker includes two first pads. The FPC includes two second pads. The springs electrically connect the first pads to the second pads.

Abstract: The present invention provides a two-step Gram staining method. The method is conducted by using a clean slide, followed by adding 10˜30 ?l primary stain from a reagent kit, adding an equivalent amount of specimens uniformly on said slide without drying and frame fixing, then immediately adding 30˜60 ?l counter-stain on said slide for incubating 15 seconds, rinsing with water, and finally examining under a microscope, the result appears color contrast on the center of the slide between the Gram-negative bacteria performing light red color and the Gram-positive bacteria performing deep purple color.

Abstract: An architecture by which combined scheduling and network coding can be used in mesh networks, and more particularly wireless mesh networks. In various embodiments, this architecture includes a scheduling MAC protocol for scheduling nodes in the mesh network in order to take advantage of network coding opportunities. The schedule takes advantage of these opportunities by assigning a gain to transmit packets based upon the number of packets that are transmitted concurrently and choosing a schedule which minimizes the gain over the scheduling horizon. Regarding the assigned gain, in one embodiment this value is one for basic non-encoded operations and two or more for encoded operations. A scheduling MAC protocol is also used to announce and arbitrate network coding opportunities by indicating which packets (as characterized by their transmission slot) are to be encoded with each other.

Abstract: A device comprises a first binding unit which provides for a binding to a first tunnelling server using a first protocol, a second binding unit which provides for a binding to a second tunnelling server using a second protocol different from the first protocol, and an authorizing unit which causes the first or second binding unit to provide the binding.