Abstract: The invention provides an image sensing device capturing a gray level image and a chromatic image on a frame via a mixing illumination of a first light and a second light. The image sensing device includes a color filter array module and a controlling module. The color filter array module includes a first filter unit, a second filter unit, a third filter unit, and a fourth filter unit. The first filter unit is used to sense a first pixel data at the frame; the second filter unit is used to sense a second pixel data at the frame; the third filter unit is used to sense a third pixel data at the frame; and the fourth filter unit is used to sense a narrow banding data. The controlling module controls the sensing form of the color filter array module according to the first light or the second light.