Abstract: An ionizable lipid based on cyclohexanediamine and a lipid nanoparticle, and a preparation method therefor and use thereof. The ionizable lipid based on cyclohexanediamine is a compound represented by formula (a), wherein n is independently selected from natural numbers of 0-8; R1, R2, R3 and R4 are independently selected from C8-C24 alkyl, C8-C24 alkyl substituted by a substituent group, C8-C24 alkenyl, C8-C24 alkenyl substituted by a substituent group, and C8-C24 alkynyl and C8-C24 alkynyl substituted by a substituent group. The lipid nanoparticle formed by the ionizable lipid based on cyclohexanediamine has the advantages of biodegradability, high in-vivo and in-vitro transfection efficiency, and the like, and has a good clinical application prospect.

Abstract: The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound shown as a formula (I), a preparation method of the substituted diaryl compound, a medicinal preparation containing the substituted diaryl compound and medical application of the substituted diaryl compound. Pharmacological test results show that the substituted diaryl compound disclosed by the invention has a good inhibition effect on cells of human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO).

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: An electrochemical device includes a shell, an electrode post, and an electrode assembly. A through-hole is provided on the shell. The electrode post is disposed on the shell and at least partially accommodated in the through-hole. The electrode post is electrically connected to the electrode assembly. A frangible portion is provided at a position corresponding to the through-hole on the electrode post. The frangible portion is configured to be burst open when a pressure in the shell reaches a threshold, so as to implement communication between inside and outside of the shell to relieve the pressure. Provided on the electrode post, the frangible portion can be broken when the pressure in the electrochemical device reaches the threshold, so as to relieve the pressure in the electrochemical device.

Abstract: A cell including an electrode assembly, a packaging bag, an inner electrode tab, and an outer electrode tab. The packaging bag includes a main body and an edge sealing portion, the electrode assembly and the inner electrode tab being received in the main body. The edge sealing portion is connected to a top wall of the main body, the other end of the outer electrode tab extends out of the packaging bag from the edge sealing portion. The top wall includes a first portion and a second portion disposed on both sides of the edge sealing portion in the thickness direction of the cell. A height from the first portion to a bottom wall of the main body is less than a height from the second portion to the bottom wall.

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: The present disclosure provides methods for obtaining plants that exhibit useful traits by perturbation of organellar function in plants. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants and grafted plants that exhibit, contain, or harbor the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for organellar perturbation are also provided.

Abstract: The present disclosure provides methods for obtaining plants that exhibit useful traits by perturbation of organellar function in plants. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants and grafted plants that exhibit, contain, or harbor the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for organellar perturbation are also provided.

Abstract: The present disclosure provides methods for obtaining plants that exhibit useful traits by perturbation of organellar function in plants. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants and grafted plants that exhibit, contain, or harbor the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for organellar perturbation are also provided.

Abstract: The invention provides a method of degrading nitrate esters by exposing a spension of a nitrate ester to a combined culture of Sclerotium rolfsii ATCC 24459 and Fusarium Solani IFO 31093. This allows an alleviation of environmental difficulties associated with the demilitarization of nitrocellulose base gun propellants and for the bioremediation of soils contaminated with such nitrocellulose based materials.