Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, CS, R2, and R3 are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: An image sensor having a brightness self-adjust capability is provided. The image sensor can include a light adjustment layer made of adaptive optical materials and a set of pixels. The image sensor can also include a control circuit configured to generate control signals to control adjustment of one or more light transparency levels at the set of pixels on the light adjustment layer based on the light intensity distribution. The image sensor can further include a sensor array configured to receive lights and facilitate output of image and/or video signals based on the received lights. For facilitating light adjustment, the control circuit can be configured to obtain light intensity distribution from a pre-sensor or the sensor array.

Abstract: Embodiments provide a smart optical filter capable of dynamically adjusting brightness variations in incident lights in a FOV or an optical field before an image sensor receives the incident lights. The smart optical filter in accordance with the disclosure can be portable and mounted on various imaging devices such as a smart phone or a camera. The smart optical filter may comprises an light adjustment layer made of an adaptive optical materials such liquid crystals. Light intensity distribution can be obtained for an FOV of a device coupled to the smart optical filter. The light intensity distribution can be compared to one or more thresholds to obtain difference values pixels on the light adjustment layer. The difference value can be used to generate control signals to adjust light passing through the pixels. In some embodiments, the control signals may include information indicating an amount of voltage to be applied to the pixels to alter polarization at those pixels.

Abstract: An image sensor system having a brightness self-adjust capability is provided. The image sensor system can include a light adjustment layer made of adaptive optical materials and a set of pixels. The image sensor system can also include a control circuit configured to generate control signals to control adjustment of one or more light transparency levels at the set of pixels on the light adjustment layer based on the light intensity distribution. The image sensor system can further include a sensor array configured to receive lights and facilitate output of image and/or video signals based on the received lights. For facilitating light adjustment, the control circuit can be configured to obtain light intensity distribution from a pre-sensor or the sensor array.

Abstract: Embodiments provide a smart optical filter capable of dynamically adjusting brightness variations in incident lights in a FOV or an optical field before an image sensor receives the incident lights. The smart optical filter in accordance with the disclosure can be portable and mounted on various imaging devices such as a smart phone or a camera. The smart optical filter may comprises an light adjustment layer made of an adaptive optical materials such liquid crystals. Light intensity distribution can be obtained for an FOV of a device coupled to the smart optical filter. The light intensity distribution can be compared to one or more thresholds to obtain difference values pixels on the light adjustment layer. The difference value can be used to generate control signals to adjust light passing through the pixels. In some embodiments, the control signals may include information indicating an amount of voltage to be applied to the pixels to alter polarization at those pixels.